Wearable Clinic: From Microneedle‐Based Sensors to Next‐Generation Healthcare Platforms

Small, Journal Year: 2023, Volume and Issue: 19(51)

Published: March 22, 2023

The rapid development of wearable biosensing calls for next-generation devices that allow continuous, real-time, and painless monitoring health status along with responsive medical treatment. Microneedles have exhibited great potential the direct access dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies microneedle-based evolved from conventional off-line detection to multiplexed, wireless, integrated sensing. In this review, classification fabrication techniques microneedles are first introduced, then representative examples transdermal different sensing modalities summarized. State-of-the-art advances therapeutic closed-loop systems presented formulate guidelines healthcare platforms. challenges prospects discussed pave new avenue toward pragmatic applications real world.

Language: Английский

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Photothermal microneedle patch loaded with antimicrobial peptide/MnO2 hybrid nanoparticles for chronic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148938 - 148938

Published: Jan. 21, 2024

Language: Английский

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Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

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A wearable self-powered microneedle system based on conductive drugs for infected wound healing: A new electrical stimulation delivery strategy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 480, P. 148347 - 148347

Published: Dec. 25, 2023

Language: Английский

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The Progress in the Application of Dissolving Microneedles in Biomedicine

Polymers, Journal Year: 2023, Volume and Issue: 15(20), P. 4059 - 4059

Published: Oct. 12, 2023

In recent years, microneedle technology has been widely used for the transdermal delivery of substances, showing improvements in drug effects with advantages minimally invasive, painless, and convenient operation. With development nano- electrochemical technology, different types microneedles are increasingly being other biomedical fields. Recent research progress shows that dissolving have achieved remarkable results fields dermatological treatment, disease diagnosis monitoring, vaccine delivery, they a wide range application prospects various fields, their great potential as form clinical treatment. This review mainly focuses on microneedles, summarizing latest providing inspiration subsequent intelligent commercial better solutions

Language: Английский

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Recent advances in hydrogel microneedle-based biofluid extraction and detection in food and agriculture

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116066 - 116066

Published: Jan. 23, 2024

Language: Английский

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Global trends in clinical trials involving engineered biomaterials

Science Advances, Journal Year: 2024, Volume and Issue: 10(29)

Published: July 17, 2024

Engineered biomaterials are materials specifically designed to interact with biological systems for biomedical applications. This paper offers the comprehensive analysis of global clinical trial trends involving such materials. We surveyed 834 studies in ClinicalTrials.gov database and explored biomaterial types, their initiation points, durations trials. Predominantly, synthetic natural polymers, particularly silicone collagen, used. Trials, focusing on ophthalmology, dentistry, vascular medicine, primarily conducted United States, Canada, Italy. These trials encompass a broad demographic, enrolled fewer than 100 participants. The study duration varied ranging from 0.5 4.5 years. mainly bioresorbable or bioinert, integration cells remaining an underexplored area. Our findings shed light current practices future potentials engineered research, offering insights advancing this dynamic field globally.

Language: Английский

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Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches with Antimicrobial and Immunomodulating Properties for Oral Mucosa Disease Treatment

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing

Language: Английский

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Hydrogen‐Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract The integration of hydrogen‐bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, application in wearable real‐time remains largely unexplored, primarily due the mechanical mismatch between traditionally fragile HOFs particles softness human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation complex environmental conditions by integrating films wavy bioelectrodes. This ultrasensitive detection capabilities, limit 49.64 nM, accurately measures nutritional content sweat while conforming curved skin surfaces. sensor's performance is comparable those obtained using high‐performance liquid chromatography (HPLC). More strikingly, scratched can be regenerated through simple solvent rinsing process, enabling reuse fabrication new biosensors offering significant advantage over conventional materials. work has potential inspire development more devices, leveraging structural adaptability diversity personalized healthcare applications monitoring.

Language: Английский

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MXene-based composites in smart wound healing and dressings

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(14), P. 3513 - 3532

Published: Jan. 1, 2024

Recent advancements in MXene-based wound dressings are discussed, focusing on their contributions to tissue regeneration, infection control, anti-inflammation and photothermal effects, targeted therapeutic delivery.

Language: Английский

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