Microchemical Journal, Journal Year: 2023, Volume and Issue: 193, P. 109257 - 109257
Published: Aug. 25, 2023
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)
Published: June 12, 2024
Abstract Advanced wireless sensors, incorporating metal‐organic frameworks (MOFs), enzymatic systems, and nanocomposites, offer unparalleled solutions for monitoring analytes human physiological signals. These cutting‐edge when used with external devices, enable real‐time of physicochemical processes within the body, thereby enhancing understanding complex biological systems. This study presents advancements in sensor development, fabrication techniques, user‐friendly protocols. The performance these sensors is evaluated based on their selectivity, sensitivity, detection limits. Moreover, this article explores limitations, challenges, key strategies to enhance analyte recognition from onsite environmental species, ensuring point‐of‐care safety.
Language: Английский
Citations
38
Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)
Published: Jan. 15, 2024
Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique evolve blood‐based diagnostics owing their direct painless access a rich source of biomarkers from interstitial fluid. This review systematically summarizes recent innovations in microneedle with particular focus on utility POC personalized medicine. The integration various sensing techniques, mostly electrochemical optical sensing, been established diverse architectures “lab‐on‐a‐microneedle” platforms. tailored geometries, mechanical flexibility, biocompatibility are constructed variety materials fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, hydrogels, elaborated state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, multiplexed sensing. employed detect wide range electrolytes, metabolites, polysaccharides, nucleic acids, proteins drugs. Insightful perspectives outlined biofluid, microneedles, biosensors, devices, theragnostic instruments, which depict bright future upcoming intelligent health management.
Language: Английский
Citations
31
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)
Published: Feb. 10, 2024
Abstract To facilitate the on‐demand release of hydrophilic antibiotics for accelerated repair infected wounds, a self‐powered wound dressing incorporating “Lock‐ON/OFF” electric field (EF)‐driven drug mechanism combined with electrical stimulation (ES) therapy is presented. When subjected to mechanical stress, exhibits controlled, slow‐release behavior, achieving remarkable cumulative rate 88.57%—89 times higher than non‐mechanical stress group. Conversely, in absence remains unreleased, maintaining 0% fully closed state. The utilizes its piezoelectric effect establish an field, enabling precise control by regulating electrostatic balance between carrier and drug. Moreover, acts as exogenous remodeling endogenous wound, accelerating closure. Combining EF‐driven ES result 1.26 fold improvement healing compared alone. This study addresses precision limitations automated diagnosis treatment, paving way advancements remote diagnosis, wireless therapy, medicine.
Language: Английский
Citations
29
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7960 - 7982
Published: Jan. 1, 2024
This review discusses the advancements, sensor design, and challenges in creating wearable implantable nucleic acid-based sensors for personalized healthcare through real-time biomarker analysis biofluids.
Language: Английский
Citations
24
Talanta, Journal Year: 2024, Volume and Issue: 281, P. 126897 - 126897
Published: Sept. 17, 2024
Language: Английский
Citations
23
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
20
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280
Published: Feb. 21, 2024
Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.
Language: Английский
Citations
18
Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 398, P. 134685 - 134685
Published: Sept. 26, 2023
Language: Английский
Citations
35
Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 630 - 630
Published: June 7, 2023
Flexible and wearable biosensors have received tremendous attention over the past decade owing to their great potential applications in field of health medicine. Wearable serve as an ideal platform for real-time continuous monitoring, which exhibit unique properties such self-powered, lightweight, low cost, high flexibility, detection convenience, conformability. This review introduces recent research progress biosensors. First all, biological fluids often detected by are proposed. Then, existing micro-nanofabrication technologies basic characteristics summarized. application manners information processing also highlighted paper. Massive cutting-edge examples introduced physiological pressure sensors, sweat self-powered As a significant content, mechanism these sensors was detailed with help readers understand this area. Finally, current challenges future perspectives proposed push area forward expand practical future.
Language: Английский
Citations
34
ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20073 - 20086
Published: Oct. 4, 2023
Despite the potential indicating role of tyrosinase (TYR) in cutaneous melanoma, how to capture real changes TYR suspicious skin remains a major challenge. Unlike traditional human serum test, this study reports sensing platform that incorporates wearable microneedle (MN) patch and trimetallic Au@Ag-Pt nanoparticles (NPs) for surface-enhanced Raman scattering (SERS) colorimetric dual-mode detecting situ toward melanoma screening. In presence TYR, catechol immobilized on MN is preferentially oxidized benzoquinone, which competitively impedes interaction NPs, triggering SERS-colorimetric signal reciprocal switch. Using B16F10 mouse model, our capable noninvasively piercing surface levels before during anti-PD-1 antibody treatment, would be highly informative prognostic judgment illness monitoring melanoma. Through capturing metabolic advance, was successfully applied discriminate subjects from moles normal ones (p < 0.001), as well screen lactate dehydrogenase (LDH)-negative patients. Melanoma growth prognosis can still monitored through recording continuous change levels. More importantly, well-defined flexible stretchable characteristics allow robustly adhering without inducing chemical or physical irritation. We believe integrating MN-based sensing, responsiveness, SERS/colorimetric dual-readout strategy will have high clinical importance early diagnosis
Language: Английский
Citations
30