International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2809 - 2809
Published: Feb. 28, 2024
This
review
focuses
on
the
latest
advancements
in
magnetic
hydroxyapatite
(mHA)
nanoparticles
and
their
potential
applications
nanomedicine
regenerative
medicine.
mHA
have
gained
significant
interest
over
last
few
years
for
great
potential,
offering
advanced
multi-therapeutic
strategies
because
of
biocompatibility,
bioactivity,
unique
physicochemical
features,
enabling
on-demand
activation
control.
The
most
relevant
synthetic
methods
to
obtain
apatite-based
materials,
either
form
iron-doped
HA
showing
intrinsic
properties
or
composite/hybrid
compounds
between
superparamagnetic
metal
oxide
nanoparticles,
are
described
as
highlighting
structure–property
correlations.
Following
this,
this
discusses
application
various
nanomaterials
bone
regeneration
nanomedicine.
Finally,
novel
perspectives
investigated
with
respect
ability
improve
nanocarriers
homogeneous
structures
promote
multifunctional
biological
applications,
such
cell
stimulation
instruction,
antimicrobial
activity,
drug
release
triggering.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(40), P. 29242 - 29253
Published: Jan. 1, 2024
The
treatment
and
regeneration
of
bone
defects,
especially
tumor-induced
is
an
issue
in
clinical
practice
remains
a
major
challenge
for
substitute
material
invention.
Cyborg and Bionic Systems,
Journal Year:
2025,
Volume and Issue:
6
Published: Jan. 1, 2025
Soft
structures
driven
by
magnetic
fields
exhibit
the
characteristics
of
being
unencumbered
and
rapidly
responsive,
enabling
fabrication
various
soft
robots
according
to
specific
requirements.
However,
made
from
a
single
material
cannot
meet
multifunctional
demands
practical
scenarios,
necessitating
development
robot
technologies
with
composite
diverse
materials.
A
novel
enhanced
digital
light
processing
(DLP)
3-dimensional
(3D)
printing
technology
has
been
developed,
capable
different
materials
in
step.
Furthermore,
hard
material–superparamagnetic
was
designed
printed,
demonstrating
its
thermal
effect
under
high-frequency
editability
domains
material.
The
exhibits
range
locomotive
behaviors,
including
crawling,
rolling,
swimming.
Under
influence
1-Hz
actuation
field,
normalized
velocities
for
these
modes
motion
are
recorded
as
0.31
body
length
per
second
1.88
0.14
demonstrated
capacity
navigate
uneven
terrain,
surmount
barriers,
engage
directed
locomotion,
along
ability
capture
transport
objects.
Additionally,
it
showcased
swimming
capabilities
within
environments
characterized
low
Reynolds
numbers
high
fluid
viscosities,
findings
that
corroborate
simulation
analyses.
multimaterial
3D
introduced
this
research
presents
extensive
potential
design
manufacturing
robots.
Nano Select,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
ABSTRACT
Natural
biomolecules
with
excellent
biocompatibility,
degradability,
and
the
ability
to
guide
effective
tissue
regeneration
are
considered
ideal
materials
for
constructing
engineering
hydrogel
scaffolds.
The
employing
of
3D
printing
technology
facilitates
preparation
natural
biomolecular‐based
scaffold
specific
morphological
requirements
engineering.
However,
there
significant
limitations
in
precise
manufacturing
such
scaffolds
using
extrusion‐based
technology.
In
this
review,
we
put
forward
challenges
encountered
process
biomolecular
inks.
Building
upon
this,
summarize
discuss
strategies
commonly
employed
enhance
performance
inks,
including
inducing
rapid
ink
cross‐linking,
improving
rheological
properties,
incorporating
auxiliary
inks
shaping,
flexibly
controlling
extrusion,
optimizing
equipment.
Furthermore,
review
offers
a
perspective
on
future
design
development
technologies
based
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101773 - 101773
Published: April 17, 2025
Bone
and
joint
diseases
are
debilitating
conditions
that
can
result
in
significant
functional
impairment
or
even
permanent
disability.
Multiscale
metal-based
nanocomposites,
which
integrate
hierarchical
structures
ranging
from
the
nanoscale
to
macroscale,
have
emerged
as
a
promising
solution
this
challenge.
These
materials
combine
unique
properties
of
nanoparticles
(MNPs),
such
enzyme-like
activities,
stimuli
responsiveness,
photothermal
conversion,
with
advanced
manufacturing
techniques,
3D
printing
biohybrid
systems.
The
integration
MNPs
within
polymer
ceramic
matrices
offers
degree
control
over
mechanical
strength,
antimicrobial
efficacy,
manner
drug
delivery,
whilst
concomitantly
promoting
processes
osteogenesis
chondrogenesis.
This
review
highlights
breakthroughs
stimulus-responsive
(e.g.,
photo-,
magnetically-,
pH-activated
systems)
for
on-demand
therapy
their
biocomposite
hybrids
containing
cells
extracellular
vesicles
mimic
native
tissue
microenvironment.
applications
these
composites
extensive,
bone
defects,
infections,
tumors,
degenerative
diseases.
emphasizes
enhanced
load-bearing
capacity,
bioactivity,
be
achieved
through
designs.
Notwithstanding
potential
applications,
barriers
progress
persist,
including
challenges
related
long-term
biocompatibility,
regulatory
hurdles,
scalable
manufacturing.
Finally,
we
propose
future
directions,
machine
learning-guided
design
patient-specific
biomanufacturing
accelerate
clinical
translation.
bridge
innovations
macroscale
functionality,
revolutionary
force
field
biomedical
engineering,
providing
personalized
regenerative
solutions
Small Science,
Journal Year:
2024,
Volume and Issue:
4(5)
Published: Feb. 26, 2024
Musculoskeletal
disorders
are
among
the
main
causes
of
disease‐associated
disability.
Moreover,
incidence
and
prevalence
osteoporosis
osteoarthritis,
as
well
risk
bone
fractures
need
for
joint
replacements,
expected
to
increase
with
longer
life
expectancy.
New
approaches
based
on
electromagnetic
stimulation
have
been
developed,
aiming
shorten
healing
time,
attenuate
implants'
osseointegration.
Inductive
coupling
(IC),
a
non‐invasive
methodology
deliver
magnetic
stimuli,
has
reached
clinical
trials
some
practices
but
is
not
yet
considered
standard
procedure.
Indeed,
its
feasibility
in
use
still
under
discussion,
optimal
parameters
fairly
undefined.
This
comprehensive
review
describes
research
trends
applicability
IC‐based
therapeutics
musculoskeletal
disorders,
starts
identifying
top‐performing
parameters.
Insights
into
stimuli
setups
that
promote
osteogenesis
provided,
pre‐clinical
evidence
from
117
vivo
studies
animal
models
human
patients.
Potential
cellular
molecular
biomechanisms
mediating
IC‐induced
effects
osteoblasts
osteoclasts
also
explored.
The
transversal
knowledge
herein
delivered
will
hopefully
support
innovative
designs
medical
devices
implement
IC
effective
therapeutic
disorders.
Advanced NanoBiomed Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Nanoarchitectonics,
as
a
post‐nanotechnology
concept,
represents
methodology
for
the
construction
of
functional
materials
employing
atoms,
molecules,
and
nanomaterials
essential
components.
The
overarching
objective
nanoarchitectonics
is
to
develop
systems
comprising
multiple
units
assembled
in
hierarchical
manner,
observed
biological
systems.
Nevertheless,
such
challenging
endeavor.
It
would
be
prudent,
therefore,
initially
focus
on
development
that
interact
with
complex
structures
living
organisms.
Accordingly,
this
review
article
addresses
topic
nanoarchitecture
it
pertains
biomedical
applications.
This
examines
current
trends
research
presents
examples
studies
support
concept
its
applications
fields.
presented
are
follows:
i)
molecular
developments,
which
mainly
based
design
assembly;
ii)
material
examples,
using
components;
iii)
porous
materials,
will
summarized
under
heading
pore‐engineered
due
their
special
structure.
Finally,
provides
an
overview
these
discusses
future
prospects.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 43
Published: Sept. 11, 2024
Tissue
engineering
has
emerged
as
a
biological
alternative
aimed
at
sustaining,
rehabilitating,
or
enhancing
the
functionality
of
tissues
that
have
experienced
partial
complete
loss
their
operational
capabilities.
The
distinctive
characteristics
electrospun
nanofibrous
structures,
such
elevated
surface-area-to-volume
ratio,
specific
pore
sizes,
and
fine
fiber
diameters,
make
them
suitable
effective
scaffolds
in
tissue
engineering,
capable
mimicking
functions
targeted
tissue.
However,
nanofibers,
whether
derived
from
natural
synthetic
polymers
combinations,
often
fall
short
replicating
multifunctional
attributes
extracellular
matrix
(ECM).
To
address
this,
nanomaterials
(NMs)
are
integrated
into
polymeric
through
various
functionalization
techniques
to
enhance
properties.
Incorporation
NMs
imparts
unique
features,
including
high
surface
area,
superior
mechanical
properties,
compositional
variety,
structural
adaptability,
exceptional
porosity,
enhanced
capabilities
for
promoting
cell
migration
proliferation.
This
review
provides
comprehensive
overview
types
NMs,
methodologies
used
integration
scaffolds,
recent
advancements
NM-functionalized
regenerating
bone,
cardiac,
cartilage,
nerve,
vascular
tissues.
Moreover,
main
challenges,
limitations,
prospects
elaborated.
