Effect of biophysical properties of tumor extracellular matrix on intratumoral fate of nanoparticles: Implications on the design of nanomedicine

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 326, P. 103124 - 103124

Published: March 7, 2024

Language: Английский

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A pH-triggered N-oxide polyzwitterionic nano-drug loaded system for the anti-tumor immunity activation research

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 16, 2024

Abstract Triple negative breast cancer (TNBC) has the characteristics of low immune cell infiltration, high expression tumor programmed death ligand 1 (PD-L1), and abundant stem cells. Systemic toxicity traditional chemotherapy drugs due to poor drug selectivity, failure resistance other problems, so it is particularly important find new treatment strategies for TNBC with limited options. Both anti-tumor natural curcumin ginsenoside Rg3 can exert effects by inducing immunogenic (ICD) cells, reducing PD-L1 expression, However, they have disadvantages water solubility, bioavailability, weak effect single agents. We used vinyl ether bonds link (Cur) N-O type zwitterionic polymers at same time encapsulated obtain hyperbranched drug-loaded micelles OPDEA-PGED-5HA@Cur@Rg3 (PPH@CR) pH response. In vitro experiments in vivo animal proved that PPH@CR could not only promote maturation dendritic cells (DCs) increase CD4 + T CD8 ICD but also reduce tissues, showed better good biological safety compared free double drugs, which a promising strategy.

Language: Английский

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Nomadic Nanomedicines: Medicines Enabled by the Paracrine Transfer Effect

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

In nanomedicine, the cellular export of nanomaterials has been less explored than uptake. Traditionally viewed in a negative light, recent findings highlight potential nanomedicine to enhance therapeutic effects. This Perspective examines key pathways for and how nanomaterial design affects removal rates. We present idea "paracrine transfer effect" (PTE), where are first internalized by "waypoint" cell then exported "destination" cell, influencing both potentially exploitable ways. Essential characteristics nanomedicines leverage PTE discussed, along with two case studies: STING-stimulating polymeric nanoparticles TLR9-stimulating liposomal spherical nucleic acids. propose future research directions better understand utilize developing more effective nanomedicines.

Language: Английский

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Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Apigenin, a widely distributed bioactive flavonoid, has recently gained excellent attention among researchers as an effective anticancer drug that can alternate cancer signaling pathways, induce programmed cell death, and reduce tumor growth in various types. Despite its impressive anti-neoplastic activity, high hydrophobicity nonspecific biodistribution make apigenin difficult for pharmaceutical application. We highlighted the therapeutic potential of derivatives different types, along with their mechanism action. Nanoengineered delivery systems have remarkable applications minimizing degradation enhancing efficacy drugs sustained release, prolonged blood retention time, reduced off-target toxicities. This review evaluated explored molecular interactions this novel flavonoid pathways to selectively inhibit neoplastic development multiple To ensure complete coverage research area, google scholar, PubMed, web science were used find not only most relevant, but also connected similar articles. A comprehensive overview nanotherapy treatment establish platform overcome difficulties application efficient clinical translation from bench bedside.

Language: Английский

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Size‐Tunable Fluorescent Unimolecular Nanoparticles (FUNs) for Bright Cancer Imaging

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Fluorescent nanoparticles such as quantum dots, carbon and polymeric fluorophore conjugates have shown promising applications for biomedical imaging. It is desirable to develop new fluorescent probes with well‐defined particle size, bright fluorescence, high biocompatibility, easy functionalization. Here, a facile controllable method first reported prepare size‐tunable unimolecular (FUNs) The FUNs are constructed by the rapid ring‐opening polymerization (ROP) of amino acid N ‐carboxyanhydrides monomers using dye‐cored polylysine dendritic macromolecule macroinitiator. By precisely adjusting ratio monomer macroinitiator, study customizes sizes 30, 60, 90, or 130 nm. fluorescence yield up 6.6‐fold small molecule dye. that size‐dependent cellular uptake, blood circulation, tumor entrance optical imaging glutamic acids (Glu)‐modified (FUNs‐Glu). FUNs‐Glu 30 60 nm exhibited superior accumulation, penetration. These dots merits tunable single‐molecule structure, excellent properties, ample groups surface functionalization, which great potential various

Language: Английский

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Multifunctional Light Emitters for Theranostics

Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 297 - 329

Published: Jan. 1, 2025

Language: Английский

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Transcytosable and Ultrasound‐Activated Liposome Enables Deep Penetration of Biofilm for Surgical Site Infection Management

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Biofilm‐associated surgical site infection (BSSI) is a common and grievous postoperative complication lacking effective remedies, mainly due to the poor drug accumulation penetration in biofilms featured by dense extracellular polymeric substances (EPSs). Here, it found that vascular cell adhesion molecule‐1 (VCAM1) highly overexpressed cells of BSSI. It proposed combination VCAM1‐mediated transcytosis ultrasonic cavitation can consecutively overcome biological barriers endothelial EPS for biofilm eradication. To demonstrate feasibility, VCAM1‐targeted ultrasound (US)‐activated liposome (LPCOTML) loaded with reactive‐oxygen‐species (ROS)‐responsive lipoid prodrug oleoyl meropenem, sonosensitizer Ce6, perfluoropentane developed. LPCOTML recognize receptors on cells, initiate receptor‐mediated transendothelial transport into BSSI periphery. subsequently transforms from nanoparticle microbubble via liquid–gas phase transition under US irradiation, triggering strong blow up deeply penetrate biofilms. The Ce6 induces ROS production irradiation triggers release meropenem induce potent antibacterial effect model. This study presents an strategy tackle combining cavitation.

Language: Английский

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Intelligent responsive nanogels: New Horizons in cancer therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125050 - 125050

Published: Dec. 5, 2024

Language: Английский

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Comparison of Drug Delivery Systems with Different Types of Nanoparticles in Terms of Cellular Uptake and Responses in Human Endothelial Cells, Pericytes, and Astrocytes

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1567 - 1567

Published: Nov. 22, 2024

Background/Objectives: The key components of the blood–brain barrier (BBB) are endothelial cells, pericytes, astrocytes, and capillary basement membrane. BBB serves as main for drug delivery to brain is most restrictive in body. Nearly all large therapeutic molecules over 90% small-molecule drugs cannot cross BBB. To overcome this challenge, nanotechnology, particularly systems such nanoparticles (NPs), have gained significant attention. Methods: Poly(lactide-co-glycolide) (PLGA) albumin-based NPs (bovine/human), with or without transferrin (Tf) ligands (BSA, HSA, BSA-Tf, HSA-Tf), nanolipid carriers (NLC) were synthesized. interactions these human microvascular cells (hBMECs), vascular pericytes (hBVPs), astrocytes (hASTROs) analyzed. Results: At doses 15.62 µg/mL, 31.25 62.5 none caused toxic effects on hBMECs, hBVPs, hASTROs after 3 h incubation. All internalized by but BSA-Tf HSA-Tf showed significantly higher uptake hBMECs a dose-dependent manner. Ultrastructural analysis revealed notable differences between NP formulation cell type. Conclusions: Our findings underscore potential ligand-targeted selectively interact cells. reveals distinct cellular processing pathways various formulations across BBB-associated types, autophagy emerging crucial mechanism handling astrocytes. Changes chemical properties upon biological exposure present challenges nanomedicine design, emphasizing need further investigation into at subcellular levels.

Language: Английский

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Magnetically Actuated Nanomaterials in Biomedical Applications

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: July 17, 2024

Magnetic nanomaterials, distinguished by their unique magnetic phenomena, particularly magnetically actuated capabilities, have found widespread application in the field of nanomedicine. Compared with alternative driving mechanisms, actuation as a remote, highly permeable, and precisely controllable strategy endows nanomaterials temporal spatia mobility, making it possible to initiate cease multiple forms movement vivo at will. When coupled cutting‐edge diagnostic treating techniques including but not limited resonance imaging, magnetothermal therapy, magnetoelectric stimulation, offer potential for visual analysis, provision reliable molecular information, effective disease or tissue damage intervention. This review comprehensively outlines synthesis methodologies, functional strategies, biomedical applications within Additionally, future developments biocompatible especially response time‐varying fields, are anticipated.

Language: Английский

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