One‐Pot Synthesis of Chiral 1‐Aryl‐2‐Aminoethanols via Ir‐Catalyzed Asymmetric Hydrogenation

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(29)

Published: March 11, 2023

A straightforward synthesis approach to chiral 1-aryl-2-aminoethanols via the one-pot asymmetric hydrogenation catalyzed by Ir catalyst was developed. This tandem process involves in situ generation of α-amino ketones nucleophilic substitution α-bromoketones with amines and Ir-catalyzed ketone intermediates provide diverse enantiomerically enriched β-amino alcohols. The excellent yields enantioselectivities (up 96 % yield up >99 ee) a wide substrate scope this strategy were obtained.

Language: Английский

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The 55^thBürgenstock Conference under the Banner of Sustainability**

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(52)

Published: Dec. 7, 2022

Language: Английский

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The 55^thBürgenstock Conference under the Banner of Sustainability**

Angewandte Chemie, Journal Year: 2022, Volume and Issue: 134(52)

Published: Dec. 7, 2022

Language: Английский

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