International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130960 - 130960
Published: March 20, 2024
Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.
Language: Английский
Citations
14IRGD-modified erythrocyte membrane biomimetic temozolomide nanodots for the treatment of glioblastoma
Nanotechnology, Journal Year: 2024, Volume and Issue: 35(24), P. 245701 - 245701
Published: Feb. 26, 2024
Abstract The crossing of the blood-brain barrier (BBB) for conventional anticancer drugs is still a big challenge in treating glioma. biomimetic nanoparticle delivery system has attracted increasing attention and promising future BBB. Herein, we construct multifunctional nanoplatform using erythrocyte membrane (EM) with tumor-penetrating peptide iRGD (CRGDK/RGPD/EC) as delivery, inner core loaded chemotherapeutic drug temozolomide (TMZ). resulting perfect biocompatibility stealth ability, which will provide more chances to escape reticuloendothelial (RES) entrapment, increase opportunity enter tumor site. Moreover, decorated been extensively used actively targeting deliver therapeutic agents across BBB into glioma tissue. We show that this TMZ diameter 22 nm efficiently slowed growth glioblastoma multiforme (GBM) increased survival rate 30 d from 0% 100%.
Language: Английский
Citations
4A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 5, 2025
Purslane (Portulaca oleracea L.) with heat-clearing and detoxicating, anti-inflammatory resolving swelling, relieving itching astringing function, has remarkable efficacy for acute eczema. However, most of the clinical applications purslane are freshly prepared decoction, not as easy to apply cream, because decoction is breed bacteria oxidize. Here, based on theory Chinese medicines compatibility, we made a purslane-tannic acid hydrogel (PL-HATA) by simple methods under mild conditions solve drawbacks oxidation inconvenience use Purslane. The antimicrobial activity PL-HATA can exert an excellent effect, reducing flora skin eczema further symptoms At same time, it creates normal reactive oxygen species (ROS) microenvironment promotes recovery from It also improves promoting cell proliferation migration. Importantly, resulted in improved lesion scores, scratching behavior, eosinophil infiltration, swelling inflammation levels, immune homeostasis, histopathological changes rats Besides, HATA only suitable Purslane's decocted metabolites but squeezed metabolites. This application protocol solved its storage stability convenience use, which key issue promote application.
Language: Английский
Citations
0A novel nitric oxide-driven nanomotor for synergistic treatment of ischaemic stroke: Enhanced deep brain penetration and therapeutic efficacy
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154205 - 154205
Published: July 24, 2024
Language: Английский
Citations
3Self-propelling, protein-bound magnetic nanobots for efficient in vitro drug delivery in triple negative breast cancer cells
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 28, 2024
Language: Английский
Citations
1Electrochemical Sensor Based on Vanadium-Substituted Tungstophosphate with Fe3o4@Au/Mof Composite Modified Glassy Carbon Electrode for Food Nitrite Detection
Published: Jan. 1, 2024
AbstractsExcessive consumption of nitrites can be harmful to human health. Therefore, the design novel electrocatalysts for efficient electrochemical quantification nitrite is important. In this paper, a magnetic metal-organic framework (Fe3O4@Au/MOF) was synthesised by self-assembly method, and vanadium-substituted tungsten phosphate (K7P2W17VO62-18H2O, P2W17V) Fe3O4@Au/MOF were loaded on glassy carbon electrodes layer-by-layer electrodeposition. Then, sensor based Fe3O4@Au/MOF-P2W17V nanocomposites prepared. Compared P2W17V, combination P2W17V not only eliminates nanoparticle aggregation, but also has large specific surface area, strong catalytic activity, good electrical conductivity. excellent properties such as faster electron transfer rate larger electrochemically active area in detection. Under optimal conditions, sensor's linear range detecting 0.1-100 mmol/L, with detection limit low 0.534 μmol/L. Furthermore, demonstrated high stability, selectivity, repeatability successfully applied detect real samples. The effective fabrication opens up new avenue determining amounts analytical applications that viable practical use.
Language: Английский
Citations
0Nanozymes: Application in Diagnostics and Therapeutics
Published: Dec. 6, 2024
Language: Английский
Citations
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