Rhodium-Catalyzed Site-Selective Coupling of Indoles with Diazo Esters: C4-Alkylation versus C2-Annulation DOI
Xiaohong Chen, Guangfan Zheng, Yunyun Li

et al.

Organic Letters, Journal Year: 2017, Volume and Issue: 19(22), P. 6184 - 6187

Published: Nov. 7, 2017

A Rh(III)-catalyzed site-selective C–H activation of C(3)-functionalized indoles in a coupling with diazo esters has been realized carbonyl as weakly coordinating group. The selectivity is dictated by the temperature and additives, affording either C4-alkylated or C2-annulated lactones moderate to excellent efficiency.

Language: Английский

“Alkene-to-Alkene” Difunctionalization of Enaminones for the Synthesis of Polyfunctionalized Alkenes by Transition-Metal-Free C–H and C–N Bond Transformation DOI

J. Ye,

Yunyun Liu,

Jin Luo

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(47), P. 8451 - 8456

Published: Nov. 16, 2023

The three-component reactions of enaminones, disulfides, and alcohols for the synthesis polyfunctionalized alkenes have been realized via C-H C-N bond transformation on enaminones. proceed in a novel "alkene-to-alkene" difunctionalization mode without using any transition metal. application alkene products divergent sulfenyl heteroaryls, including sulfenylated pyrazoles, pyrimidines, isoxazoles, simple annulation has also verified.

Language: Английский

Citations

29
Recent advances in transition metal-catalyzed transformations in N,N-disubstituted enaminones DOI
Leiqing Fu, Jie‐Ping Wan

Tetrahedron Letters, Journal Year: 2023, Volume and Issue: 130, P. 154766 - 154766

Published: Sept. 26, 2023

Language: Английский

Citations

28
Three-Component Fusion to Pyrazolo[5,1-a]isoquinolines via Rh-Catalyzed Multiple Order Transformation of Enaminones DOI

Demao Chen,

Changfeng Wan, Yunyun Liu

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(7), P. 4833 - 4838

Published: March 22, 2023

A facile and practical method for the synthesis of fused tricyclic pyrazolo[5,1-a]isoquinolines has been realized via reactions enaminones, hydrazine hydrochloride, internal alkynes. By means Rh catalysis, extraordinary high-order bond functionalization, including transformation aryl C–H, ketone C═O, alkenyl C–N bonds in marks major feature cascade reactions. The results disclose individual advantage enaminones design novel efficient synthetic methods.

Language: Английский

Citations

23
Divergent Access to 1-Naphthols and Isocoumarins via Rh(III)-Catalyzed C–H Activation Assisted by Phosphonium Ylide DOI
Yunyun Li, Qiang Wang, Xifa Yang

et al.

Organic Letters, Journal Year: 2017, Volume and Issue: 19(13), P. 3410 - 3413

Published: June 12, 2017

Rh-catalyzed C–H activation of phenacyl phosphoniums in coupling with α-diazocarbonyl compounds has been realized the assistance a mutifunctional phosphonium ylidic directing group, providing expedient accesses to 1-naphthols and isocoumarins. Switchable synthesis isocoumarins was by substrate control, where these transformations were enabled initial subsequent intramolecular Wittig reaction or nucleophilic C–O formation.

Language: Английский

Citations

81
Rhodium-Catalyzed Site-Selective Coupling of Indoles with Diazo Esters: C4-Alkylation versus C2-Annulation DOI
Xiaohong Chen, Guangfan Zheng, Yunyun Li

et al.

Organic Letters, Journal Year: 2017, Volume and Issue: 19(22), P. 6184 - 6187

Published: Nov. 7, 2017

A Rh(III)-catalyzed site-selective C–H activation of C(3)-functionalized indoles in a coupling with diazo esters has been realized carbonyl as weakly coordinating group. The selectivity is dictated by the temperature and additives, affording either C4-alkylated or C2-annulated lactones moderate to excellent efficiency.

Language: Английский

Citations

81