Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(12), P. 2715 - 2720
Published: May 9, 2024
Abstract
A
one‐pot
multi‐component
reaction
strategy
for
the
selective
synthesis
of
5‐trifluoromethyl
pyrimidine
derivatives
has
been
established.
This
method
avoids
inherent
selectivity
challenges
in
direct
trifluoromethylation.
The
demonstrates
tolerance
to
various
functional
groups,
yielding
with
up
80%
yields.
Moreover,
practicality
this
underscored
through
scale‐up
reactions.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2505 - 2515
Published: Feb. 5, 2024
A
novel
iodine-promoted
difunctionalization
of
α-C
sites
in
enaminones
was
demonstrated
as
a
means
synthesizing
variety
fully
substituted
thiazoles
by
constructing
C–C(CO),
C–S,
and
C–N
bonds.
This
transformation
allows
the
realization
unusual
aryl
C2
synthons
simultaneously
thioylation
dicarbonylation
sites.
preliminary
mechanistic
study
performed
indicated
that
cleavage
C═C
bonds
involves
bicyclization/ring-opening
oxidative
coupling
sequence.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2363 - 2369
Published: March 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(15), P. 1727 - 1733
Published: March 26, 2024
Comprehensive
Summary
Chemodivergent
synthesis
of
benzofurans
and
2,3‐dihydrobenzofurans
has
been
realized.
Under
a
reaction
system
consisting
DBDMH
K
2
CO
3
as
promotors,
controlled
conditions
enabled
the
formation
two
sets
valuable
heterocycles
from
tandem
transformation
enaminones
salicylaldehydes.
The
key
to
success
was
identification
parameters,
in
which
imine
intermediate
formed
by
transient
halogenation
coupling
substitution
processes
underwent
either
aldol
condensation/annulation
or
hydrolysis/aldol
condensation.
additives
NH
4
Cl
Fe
(SO
)
unique
selectivity
this
reaction.
A
broad
substrate
scope
salicylaldehydes
employed
reaction,
demonstrating
excellent
functional
group
tolerance
versatility.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 11060 - 11066
Published: July 24, 2024
Reported
herein
is
a
new
photocatalytic
annulation
for
the
synthesis
of
2,3,4,6-tetrasubstituted
pyridines
with
enaminones
and
N,N,N′,N′-tetramethyl
ethylenediamine
(TMEDA).
The
reactions
take
place
without
requiring
transition
metal
reagent
provide
products
broad
scope.
methyl
in
TMEDA
acts
as
carbon
source
pyridine
ring
construction,
BrCF2CO2Et
plays
role
terminal
oxidant
free
radical
quenching.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8521 - 8530
Published: June 3, 2024
An
oxidative
free-radical
C(sp2)–H
bond
chlorination
strategy
of
enaminones
has
been
developed
by
using
LiCl
as
a
chlorinating
reagent
and
K2S2O8
an
oxidant.
This
transformation
provides
new
straightforward
synthetic
methodology
to
afford
highly
functionalized
α-chlorinated
with
Z-configuration
in
good
excellent
yields.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9078 - 9085
Published: June 3, 2024
The
α-C–H
trifluoromethylthiolation
of
N,N-disubstituted
enaminones
has
been
achieved
with
simple
and
cheap
CF3SO2Na
as
the
CF3S
source.
reactions
were
run
at
mild
temperature
(0
°C
to
rt)
using
POCl3
only
reducing
reagent.
work
represents
first
example
on
synthesis
α-trifluoromethylthio
via
direct
C–H
functionalization.
In
addition,
resulting
CF3S-functionalized
have
proven
useful
building
blocks
in
various
heteroaromatic
compounds
by
annulation
reactions.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(16), P. 2565 - 2571
Published: April 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
