Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(5), P. 2200 - 2206

Published: Jan. 28, 2021

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3) acids with labeled CO2. Substrates that are not compatible transition-metal-catalyzed degradation–reconstruction approaches or prone to thermally induced reversible decarboxylation undergo incorporation at room temperature in short reaction times. The radiolabeling drug molecules and precursors [11C]CO2 is demonstrated.

Language: Английский

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¹⁸F-Trifluoromethanesulfinate Enables Direct C–H ¹⁸F-Trifluoromethylation of Native Aromatic Residues in Peptides

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(3), P. 1180 - 1185

Published: Jan. 8, 2020

18F labeling strategies for unmodified peptides with [18F]fluoride require 18F-labeled prosthetics bioconjugation more often cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic residues applying C–H 18F-trifluoromethylation. We report a one-step route [18F]CF3SO2NH4 from and its application direct [18F]CF3 incorporation at tryptophan tyrosine using as complex recombinant human insulin. The fully automated radiosynthesis of octreotide[Trp(2-CF218F)] enables in vivo positron emission tomography imaging.

Language: Английский

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Insight into the Development of PET Radiopharmaceuticals for Oncology

Cancers, Journal Year: 2020, Volume and Issue: 12(5), P. 1312 - 1312

Published: May 21, 2020

While the development of positron emission tomography (PET) radiopharmaceuticals closely follows that traditional drug development, there are several key considerations in chemical and radiochemical synthesis, preclinical assessment, clinical translation PET radiotracers. As such, we outline fundamentals radiotracer design, with respect to selection an appropriate pharmacophore. These concepts will be reinforced by exemplary cases both their evaluation. We also provide a guideline for proper radionuclide labeling strategy access tracer optimal imaging qualities. Finally, summarize methodology evaluation vitro animal models road translation. This review is intended primer newcomers field give insight into workflow developing radiopharmaceuticals.

Language: Английский

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Regulation of Porosity in MOFs: A Review on Tunable Scaffolds and Related Effects and Advances in Different Applications

Journal of environmental chemical engineering, Journal Year: 2022, Volume and Issue: 10(6), P. 108836 - 108836

Published: Oct. 21, 2022

Language: Английский

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[18F]Difluorocarbene for positron emission tomography

Nature, Journal Year: 2022, Volume and Issue: 606(7912), P. 102 - 108

Published: March 28, 2022

Language: Английский

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