Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(10), P. 2207 - 2207
Published: Oct. 17, 2022
Radiolabeled
amino
acids
are
an
important
class
of
agents
for
positron
emission
tomography
imaging
that
target
acid
transporters
in
many
tumor
types.
Traditional
18F-labeled
synthesis
strategies
always
based
on
nucleophilic
aromatic
substitution
reactions
with
multistep
radiosynthesis
and
low
radiochemical
yields.
In
recent
years,
new
18F-labeling
methodologies
such
as
metal-catalyzed
radiofluorination
heteroatom
(B,
P,
S,
Si,
etc.)-18F
bond
formation
being
effectively
used
to
synthesize
radiopharmaceuticals.
This
review
focuses
advances
the
synthesis,
radiolabeling,
application
a
series
analogs
using
strategies.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(37)
Published: June 27, 2023
A
palladium-catalyzed
reductive
difluorocarbene
transfer
reaction
that
tames
to
couple
with
two
electrophiles
has
been
developed,
representing
a
new
mode
of
reaction.
The
approach
uses
low-cost
and
bulk
industrial
chemical
chlorodifluoromethane
(ClCF2
H)
as
the
precursor.
It
produces
variety
difluoromethylated
(hetero)arenes
from
widely
available
aryl
halides/triflates
proton
sources,
featuring
high
functional
group
tolerance
synthetic
convenience
without
preparing
organometallic
reagents.
Experimental
mechanistic
studies
reveal
an
unexpected
Pd0/II
catalytic
cycle
is
involved
in
this
reaction,
wherein
oxidative
addition
palladium(0)
([Pd0
(Ln
)]=CF2
)
electrophile
generate
key
intermediate
aryldifluoromethylpalladium
[ArCF2
Pd(Ln
)X],
followed
by
hydroquinone,
responsible
for
transfer.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
24(4)
Published: March 19, 2024
Abstract
Layered
double
hydroxides
(LDH)
are
a
class
of
functional
anionic
clays
that
typically
consist
orthorhombic
arrays
metal
with
anions
sandwiched
between
the
layers.
Due
to
their
unique
properties,
including
high
chemical
stability,
good
biocompatibility,
controlled
drug
loading,
and
enhanced
bioavailability,
LDHs
have
many
potential
applications
in
medical
field.
Especially
fields
bioimaging
tumor
therapy.
This
paper
reviews
research
progress
nanocomposites
field
imaging
First,
structure
advantages
LDH
discussed.
Then,
several
commonly
used
methods
for
preparation
presented,
co‐precipitation,
hydrothermal
ion
exchange
methods.
Subsequently,
recent
advances
layered
cancer
therapy
highlighted.
Finally,
based
on
current
research,
we
summaries
prospects
challenges
diagnosis
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(42)
Published: June 21, 2022
Abstract
Immunotherapy
is
one
of
the
most
promising
clinical
modalities
for
treatment
malignant
tumors
and
has
shown
excellent
therapeutic
outcomes
in
settings.
However,
it
continues
to
face
several
challenges,
including
long
cycles,
high
costs,
immune‐related
adverse
events,
low
response
rates.
Thus,
critical
predict
rate
immunotherapy
by
using
imaging
technology
preoperative
intraoperative.
Here,
latest
advances
nanosystem‐based
biomaterials
used
predicting
responses
via
immune
cells
signaling
molecules
microenvironment
are
comprehensively
summarized.
Several
methods,
such
as
fluorescence
imaging,
magnetic
resonance
positron
emission
tomography
ultrasound
photoacoustic
predictive
discussed
show
potential
nanosystems
distinguishing
responders
from
nonresponders.
Nanosystem‐based
aided
various
technologies
expected
enable
effective
prediction
diagnosis
cases
tumors,
inflammation,
other
public
diseases.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(24), P. 16902 - 16911
Published: June 7, 2024
Despite
the
synthetic
versatility
of
difluorocarbene,
its
high
reactivity
severely
regulates
widespread
applications
difluorocarbene
in
organic
synthesis.
Here,
we
report
a
copper
difluorocarbene-involved
catalytic
coupling,
representing
new
mode
difluoromethylation
reaction.
This
method
allows
wide
range
readily
available
allyl/propargyl
electrophiles
with
NaBH
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(44), P. 23899 - 23904
Published: Oct. 25, 2023
The
first
oxidative
chloro-
and
bromodifluoromethylation
of
phenols
with
(CH3)3SiCF2X
CuX
(X
=
Cl
or
Br)
in
the
presence
Selectfluor
under
mild
reaction
conditions
was
developed.
This
protocol
provided
a
practical
efficient
method
for
synthesis
diverse
range
biologically
valuable
synthetically
challenging
bromodifluoromethyl
aryl
ethers.
Preliminary
mechanistic
studies
suggest
that
this
proceeded
through
difluorocarbene-involved
coupling
process.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(26)
Published: April 19, 2024
The
difluoromethyl
functionality
has
proven
useful
in
drug
discovery,
as
it
can
modulate
the
properties
of
bioactive
molecules.
For
PET
imaging,
this
structural
motif
been
largely
underexploited
(pre)clinical
radiotracers
due
to
a
lack
user-friendly
radiosynthetic
routes.
This
Minireview
provides
an
overview
challenges
facing
radiochemists
and
summarises
efforts
made
date
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