Chemistry - A European Journal,
Journal Year:
2019,
Volume and Issue:
25(44), P. 10323 - 10327
Published: June 19, 2019
Abstract
The
development
of
efficient
and
mild
methods
for
the
synthesis
organofluorine
compounds
is
foremost
interest
in
various
fields
chemistry.
A
direct
pyrimidine‐based
selective
meta
‐C−H
perfluoroalkenylation
arenes
involving
several
commercially
available
perfluoroolefins
described.
synthetic
versatility
protocol
demonstrated
by
an
extensive
substrate
scope
including
different
benzylsulfonyl,
alkylarene
phenylacetic
acid
scaffolds.
generality
this
methodology
Ibuprofen,
facile
cleavage
directing
group
gram‐scale
reactions
are
presented.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(18), P. 10079 - 10144
Published: Aug. 14, 2020
A
large
proportion
of
protein–protein
interactions
(PPIs)
occur
between
a
short
peptide
and
globular
protein
domain;
the
peptides
involved
in
surface
play
important
roles,
there
is
great
promise
for
using
motifs
to
interfere
with
interactions.
Peptide
inhibitors
show
more
blocking
compared
small
molecule
inhibitors.
However,
have
drawbacks
including
poor
stability
against
circulating
proteolytic
enzymes
an
intrinsic
inability
penetrate
cell
membranes.
Stapled
helical
peptides,
by
adopting
preformed,
stable
α-helical
conformation,
exhibit
improved
membrane
permeability
linear
bioactive
peptides.
In
this
review,
we
summarize
broad
aspects
stapling
chemistry,
biophysics,
biological
applications
specifically
highlight
methodology
providing
inventory
different
anchoring
residues
categorized
into
two
natural
amino
acids,
nonnatural
or
combination
acids.
Additional
advantages
specific
techniques,
but
not
limited
reversibility,
bio-orthogonal
reactivity,
photoisomerization,
are
also
discussed
individually.
This
review
expected
provide
reference
rational
design
druggable
stapled
targeting
therapeutic
proteins,
particularly
those
PPIs,
considering
impact
residues,
functional
cross-linkers,
physical
staple
length,
components,
motif
on
biophysical
properties
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(19), P. 7461 - 7466
Published: Feb. 20, 2020
Disclosed
herein
is
the
visible-light-promoted
deaminative
C(sp3
)-H
alkylation
of
glycine
and
peptides
using
Katritzky
salts
as
electrophiles.
Simple
reaction
conditions
excellent
functional-group
tolerance
provide
a
general
strategy
for
efficient
preparation
unnatural
α-amino
acids
precise
modification
with
α-amino-acid
residues.
Mechanistic
studies
suggest
that
intermolecular
charge
transfer
within
glycine-Katritzky
salt
electron
donor-acceptor
(EDA)
complex
induces
single-electron
process
without
assistance
photocatalyst.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(19), P. 11269 - 11335
Published: Sept. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
This
review
provides
an
account
of
the
tryptophan-specific
conjugation
peptides
and
proteins
its
extensive
application
in
imaging
living
cells,
radiolabelling
proteins,
protein
engineering,
etc
.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(7), P. 2039 - 2059
Published: Jan. 1, 2020
Peptide
macrocyclization
continues
expanding
with
the
development
of
novel
transition
metal-catalyzed
reactions
capable
both
introducing
conformational
constraints
and
generating
diversity
at
ring-closing
moiety.
Chemical Science,
Journal Year:
2020,
Volume and Issue:
12(8), P. 2890 - 2897
Published: Dec. 28, 2020
The
merger
of
manganese-catalyzed
C–H
functionalization
with
electrosynthesis
enabled
C(sp
3
)–H
azidation
devoid
chemical
oxidants
or
photochemical
irradiation.
Detailed
mechanistic
studies
are
supportive
a
manganese(
iii/iv
)
electrocatalysis.
Chemical Science,
Journal Year:
2020,
Volume and Issue:
11(25), P. 6521 - 6526
Published: Jan. 1, 2020
C–H
glycosylations
of
complex
amino
acids
and
peptides
were
accomplished
through
the
assistance
triazole
peptide-isosteres.
The
palladium-catalyzed
glycosylation
provided
access
to
C-glycosides
fluorescent-labeled
glycoamino
acids.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: June 7, 2021
Abstract
Bioorthogonal
late-stage
diversification
of
amino
acids
and
peptides
bears
enormous
potential
for
drug
discovery
molecular
imaging.
Despite
major
accomplishments,
these
strategies
largely
rely
on
traditional,
lengthy
prefunctionalization
methods,
heavily
involving
precious
transition-metal
catalysis.
Herein,
we
report
a
resource-economical
manganese(I)-catalyzed
C–H
fluorescent
labeling
structurally
complex
ensured
by
direct
alkynylation
alkenylation
manifolds.
This
modular
strategy
sets
the
stage
unraveling
structure-activity
relationships
between
discrete
fluorophores
towards
rational
design
BODIPY
fluorogenic
probes
real-time
analysis
immune
cell
function.
