Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(24), P. 9365 - 9369
Published: Feb. 24, 2020
Abstract
Molecular‐surfactant‐stabilized
emulsions
are
susceptible
to
coalescence
and
Ostwald
ripening.
Amphiphilic
particles,
which
have
a
much
stronger
anchoring
strength
at
the
interface,
could
effectively
alleviate
these
problems
form
stable
Pickering
emulsions.
Herein,
we
describe
versatile
method
fabricate
biocompatible
amphiphilic
dimer
particles
through
controlled
coprecipitation
phase
separation.
The
consist
of
hydrophobic
PLA
bulb
hydrophilic
shellac–PEG
bulb,
thus
resembling
nonionic
molecular
surfactants.
size
diameter
ratio
readily
tunable,
providing
flexible
control
over
water/oil
interfacial
curvature
type
emulsion.
particle‐stabilized
were
for
long
period
time
be
destabilized
pH‐triggered
response.
with
tunable
morphology
functionality
ideal
colloidal
surfactants
various
applications.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(45), P. 20065 - 20074
Published: Aug. 3, 2020
Abstract
Understanding
drug‐release
kinetics
is
critical
for
the
development
of
drug‐loaded
nanoparticles.
We
developed
a
J‐aggregate‐based
Förster‐resonance
energy‐transfer
(FRET)
method
to
investigate
release
novel
high‐drug‐loading
(50
wt
%)
nanoparticles
in
comparison
with
low‐drug‐loading
(0.5
Single‐dye‐loaded
form
J‐aggregates
because
high
dye‐loading
%),
resulting
large
red‐shift
(≈110
nm)
fluorescence
spectrum.
Dual‐dye‐loaded
using
FRET
pairs
exhibited
not
only
but
also
J‐aggregate
(116
nm).
Using
this
method,
dye‐core–polymer‐shell
showed
two
processes
intracellularly:
dissolution
dye
aggregates
into
molecules
and
from
polymer
shell.
Also,
high‐dye‐loading
slow
serum
relatively
quick
cells,
demonstrating
their
great
potential
drug
delivery.
Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
11(5), P. 1341 - 1354
Published: Oct. 21, 2020
Breast
cancer
brain
metastases
(BCBMs)
are
one
of
the
most
difficult
malignancies
to
treat
due
intracranial
location
and
multifocal
growth.
Chemotherapy
molecular
targeted
therapy
extremely
ineffective
for
BCBMs
inept
accumulation
because
formidable
blood‒brain
barrier
(BBB).
Accumulation
studies
prove
that
low
density
lipoprotein
receptor-related
protein
1
(LRP1)
is
promising
target
BBB
transcytosis.
However,
as
primary
clearance
receptor
amyloid
beta
tissue
plasminogen
activator,
LRP1
at
abluminal
side
can
clear
LRP1-targeting
therapeutics.
Matrix
metalloproteinase-1
(MMP1)
highly
enriched
in
metastatic
niche
promote
growth
BCBMs.
Herein,
it
reported
nanoparticles
(NPs-K-s-A)
tethered
with
MMP1-sensitive
fusion
peptide
containing
HER2-targeting
K
angiopep-2
(A),
surmount
escape
LRP1-mediated
niche.
NPs-K-s-A
revealed
infinitely
superior
angiopep-2-decorated
NPs-A
bearing
mice,
while
comparable
normal
mice.
The
delivered
doxorubicin
lapatinib
synergistically
inhibit
prolongs
survival
mice
Due
efficient
penetration,
special
remarkable
escape,
facilitated
therapeutic
outcome,
peptide-based
drug
delivery
strategy
may
serve
a
potential
approach
clinical
management
Small,
Journal Year:
2020,
Volume and Issue:
16(30)
Published: June 23, 2020
Co-precipitation
is
generally
refers
to
the
co-precipitation
of
two
solids
and
widely
used
prepare
active-loaded
nanoparticles.
Here,
it
demonstrated
that
liquid
solid
can
precipitate
simultaneously
produce
hierarchical
core-shell
nanocapsules
encapsulate
an
oil
core
in
a
polymer
shell.
During
process,
preferentially
deposits
at
oil/water
interface,
wetting
both
water
phases;
behavior
determined
by
spreading
coefficients
driven
energy
minimization.
The
technique
applicable
directly
various
actives
avoid
use
toxic
solvent
or
surfactant
during
preparation
process.
obtained
harness
advantage
biocompatibility,
precise
control
over
shell
thickness,
high
loading
capacity,
encapsulation
efficiency,
good
dispersity
water,
improved
stability
against
oxidation.
applications
as
delivery
vehicles
are
excellent
performances
natural
colorant
anti-cancer
drug-loaded
nanocapsules.
with
controlled
structure
are,
therefore,
ideal
carriers
for
practical
food,
cosmetics,
drug
delivery.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(24), P. 9365 - 9369
Published: Feb. 24, 2020
Abstract
Molecular‐surfactant‐stabilized
emulsions
are
susceptible
to
coalescence
and
Ostwald
ripening.
Amphiphilic
particles,
which
have
a
much
stronger
anchoring
strength
at
the
interface,
could
effectively
alleviate
these
problems
form
stable
Pickering
emulsions.
Herein,
we
describe
versatile
method
fabricate
biocompatible
amphiphilic
dimer
particles
through
controlled
coprecipitation
phase
separation.
The
consist
of
hydrophobic
PLA
bulb
hydrophilic
shellac–PEG
bulb,
thus
resembling
nonionic
molecular
surfactants.
size
diameter
ratio
readily
tunable,
providing
flexible
control
over
water/oil
interfacial
curvature
type
emulsion.
particle‐stabilized
were
for
long
period
time
be
destabilized
pH‐triggered
response.
with
tunable
morphology
functionality
ideal
colloidal
surfactants
various
applications.
