Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(28), P. 15426 - 15435
Published: April 1, 2021
Abstract
A
general
strategy
to
carry
out
cell
uptake
and
biodistribution
studies
is
label
nanoparticles
(NPs)
with
a
fluorescent
dye.
However,
the
comparative
study
of
different
dye‐loaded
NPs
remains
difficult
owing
uncontrolled
dye
quenching
de‐quenching.
Here
we
compared
two
types
dye‐labeled
demonstrated
their
distinct
properties.
molecules
at
solid
state
suffer
from
quenching,
so
release
and/or
NP
degradation
in
biological
environments
leads
several‐fold
increase
fluorescence
intensity
despite
same
amount
NPs,
switch
In
contrast,
soluble
exhibit
no
effect.
To
standardize
study,
propose
possible
solutions:
using
lower
loading
or
medium
analysis
for
quantifying
NPs.
This
work
provides
valuable
insights
into
selecting
valid
quantification
methods
bio‐nano
studies.
Small,
Journal Year:
2022,
Volume and Issue:
18(36)
Published: April 9, 2022
Abstract
Nanoparticles
(NPs)
have
attracted
tremendous
interest
in
drug
delivery
the
past
decades.
Microfluidics
offers
a
promising
strategy
for
making
NPs
due
to
its
capability
precisely
controlling
NP
properties.
The
recent
success
of
mRNA
vaccines
using
microfluidics
represents
big
milestone
microfluidic
pharmaceutical
applications,
and
rapid
scaling
up
demonstrates
feasibility
industrial‐scale
manufacturing.
This
article
provides
critical
review
progress
delivery.
First,
synthesis
organic
focusing
on
typical
methods
their
applications
popular
clinically
relevant
NPs,
such
as
liposomes,
lipid
polymer
well
mechanisms
are
summarized.
Then,
several
representative
inorganic
(e.g.,
silica,
metal,
metal
oxide,
quantum
dots),
hybrid
is
discussed.
Lastly,
various
presented.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(16)
Published: April 20, 2022
We
designed
a
unique
nanocapsule
for
efficient
single
CRISPR-Cas9
capsuling,
noninvasive
brain
delivery
and
tumor
cell
targeting,
demonstrating
an
effective
safe
strategy
glioblastoma
gene
therapy.
Our
nanocapsules
can
be
simply
fabricated
by
encapsulating
the
Cas9/sgRNA
complex
within
glutathione-sensitive
polymer
shell
incorporating
dual-action
ligand
that
facilitates
BBB
penetration,
selective
release.
evidenced
promising
tissue
targeting
led
to
high
PLK1
editing
efficiency
in
(up
38.1%)
with
negligible
(less
than
0.5%)
off-target
high-risk
tissues.
Treatment
extended
median
survival
time
(68
days
versus
24
nonfunctional
sgRNA-treated
mice).
new
system
thus
addresses
various
challenges
demonstrate
tumor-specific
of
Cas9
ribonucleoprotein
improved
treatment
may
potentially
therapeutically
useful
other
diseases.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Aug. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(49), P. 17263 - 17271
Published: Dec. 4, 2022
A
fluorescent
and
photothermal
dual-mode
assay
method
was
established
for
the
detection
of
acetylcholinesterase
(AChE)
activity
based
on
in
situ
formation
o-phenylenediamine
(oPD)
cascade
polymers.
First,
copper
metal–organic
frameworks
benzenetricarboxylic
acid
(Cu-BTC)
were
screened
out
as
nanozymes
with
excellent
oxidase-like
confinement
catalysis
effect.
Then,
an
ingenious
oPD
polymerization
strategy
proposed.
That
is,
oxidized
by
Cu-BTC
to
oligomers
strong
yellow
fluorescence,
further
catalyzed
generate
J-aggregation,
which
promotes
polymer
nanoparticles
a
high
By
utilizing
thiocholine
(enzymolysis
product
acetylthiocholine)
inhibit
catalytic
effect,
AChE
detected
through
fluorescence–photothermal
dual-signal
change
nanoparticles.
Both
modes
have
low
limitation
(0.03
U
L–1
fluorescence
0.05
photothermal)
can
accurately
detect
human
serum
(recovery
85.0–111.3%).
The
results
real
samples
dual
are
consistent
each
other
(relative
error
≤
5.2%).
It
is
worth
emphasizing
that
this
first
time
report
effect
polymers
enzyme
activity.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107150 - 107150
Published: March 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: July 11, 2022
Abstract
With
the
continuous
development
of
organic
materials
for
optoelectronic
devices
and
biological
applications,
J‐aggregation
has
attracted
a
great
deal
interest
in
both
dye
chemistry
supramolecular
chemistry.
Except
characteristic
red‐shifted
absorption
emission,
such
ordered
head‐to‐tail
stacked
structures
may
be
accompanied
by
special
properties
as
enhanced
absorption,
narrowed
spectral
bandwidth,
improved
photothermal
photodynamic
properties,
aggregation‐induced
emission
enhancement
(AIEE)
phenomenon,
so
forth.
These
excellent
add
potential
to
J‐aggregates
optical
imaging
phototherapy
near‐infrared
(NIR)
region.
Despite
decades
development,
challenge
rationally
designing
molecular
structure
adjust
intermolecular
forces
induce
dyes
remains
significant.
In
this
review,
we
discuss
formation
terms
interactions
summarize
some
recent
studies
on
NIR
phototherapy,
provide
clear
direction
reference
better
enable
applications.
This
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Diagnostic
Tools
Vivo
Nanodiagnostics
Imaging
Nanomedicine
Oncologic
Disease
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(41), P. 46201 - 46211
Published: Oct. 8, 2022
Covalent
organic
frameworks
(COFs)
show
great
potential
in
biomedicine,
but
the
synthesis
of
fluorescent
ones
with
a
highly
conjugated
structure
mild
conditions
remains
challenge.
Herein,
we
reported
facile
method
to
synthesize
nanosized,
conjugated,
and
N-enriched
COF
material
bright
fluorescence
further
integrated
it
as
novel
nanoplatform
for
efficient
cancer
starvation/gas
therapy.
High
surface
area
porous
endowed
COFs
large
loading
capacity
both
glucose
oxidase
l-arginine,
while
monomer
N-doping
guaranteed
relatively
strong
interactions
between
loaded
cargos.
Well-designed
size
allowed
easy
cell
uptake
drug-loaded
COFs,
which
finally
resulted
starvation
therapy
by
consuming
amounts
cells.
H2O2,
byproduct
during
consumption,
was
made
full
use
oxidizing
l-arginine
generate
toxic
NO.
This
constructed
combined
gas
exhibited
emerging
antimigration
performance.
Both
vitro
vivo
experiments
confirmed
an
excellent
therapeutic
effect
than
single
therapy,
platform
showed
good
biocompatibility.
Detailed
mechanism
study
demonstrated
that
apoptosis
lysosomal
damage
contributed
most
synergistic
treatment.
Our
developed
new
strategy
applications
