Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

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Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(22)

Published: March 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(36), P. 15320 - 15330

Published: Aug. 21, 2020

Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration an excess amount exogenous Fenton-type heavy metals may cause potential adverse effects human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as endogenous source Fenton-reactive for eliciting free generation, discovery hydroperoxides (R′OOH) optimal LIP-mediated agent against cancer. By simulating metabolic fates peroxo compounds within cells, R′OOH was found have excellent radical-producing ability in presence iron(II) suffer only moderate elimination by glutathione/glutathione peroxidase, which contributes its superior efficacy. The LIP-initiated nontoxic-to-toxic R′OOH, together increased LIP levels tumor enabled efficient specific Moreover, pH/labile cascade-responsive nanomedicines comprising encapsulated methyl linoleate hydroperoxide LIP-increasing pH-sensitive polymer particles were fabricated realize enhanced CDT. This work not paves way using cancer but also offers paradigm exploration high-performance agents activated LIP.

Language: Английский

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Supramolecular Polymerization‐Induced Nanoassemblies for Self‐Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(32), P. 17570 - 17578

Published: May 27, 2021

The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H

Language: Английский

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A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: June 14, 2020

The incorporation of new modalities into chemotherapy greatly enhances the anticancer efficacy combining merits each treatment, showing promising potentials in clinical translations. Herein, a hybrid nanomedicine (Au/FeMOF@CPT NPs) is fabricated using metal-organic framework (MOF) nanoparticles and gold (Au as building blocks for cancer chemo/chemodynamic therapy. MOF NPs are used vehicles to encapsulate camptothecin (CPT), hybridization by Au improves stability physiological environment. Triggered high concentration phosphate inside cells, Au/FeMOF@CPT effectively collapse after internalization, resulting complete drug release activation cascade catalytic reactions. intracellular glucose can be oxidized produce hydrogen dioxide, which further utilized chemical fuel Fenton reaction, thus realizing synergistic efficacy. Benefitting from enhanced permeability retention effect sophisticated fabrications, blood circulation time tumor accumulation significantly increased. In vivo results demonstrate that combination chemodynamic therapy suppresses growth, meantime systemic toxicity this avoided.

Language: Английский

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A Site Distance Effect Induced by Reactant Molecule Matchup in Single‐Atom Catalysts for Fenton‐Like Reactions

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(33)

Published: June 20, 2022

Abstract Understanding the site interaction nature of single‐atom catalysts (SACs), especially densely populated SACs, is vital for their application to various catalytic reactions. Herein, we report a distance effect, which emphasizes how well adjacent copper atoms (denoted as d Cu1−Cu1 ) matches with reactant peroxydisulfate (PDS) molecular size determine Fenton‐like reaction reactivity on carbon‐supported SACs. The optimized in range 5–6 Å, PDS, endows catalyst nearly two times higher turnover frequency than that beyond this range, accordingly achieving record‐breaking kinetics oxidation emerging organic contaminants. Further studies suggest effect originates from alteration PDS adsorption dual‐site structure Cu 1 −Cu sites when falls within significantly enhancing interfacial charge transfer and consequently resulting most efficient activation so far.

Language: Английский

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Light-free Generation of Singlet Oxygen through Manganese-Thiophene Nanosystems for pH-Responsive Chemiluminescence Imaging and Tumor Therapy

Chem, Journal Year: 2020, Volume and Issue: 6(9), P. 2314 - 2334

Published: July 10, 2020

Language: Английский

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One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 617 - 630

Published: Dec. 27, 2021

Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen (H2O2) self-supplying agent for enhanced tumor therapy. However, a single kind of is insufficient to achieve more effective antitumor performance. Here, hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by simple one-step strategy. After accumulation at the site due permeability retention (EPR) effect specific recognition hyaluronate with CD44 protein on surface cells, plenty Ca2+, Cu2+, H2O2 can be simultaneously released in hyaluronidase overexpressed microenvironment (TME), generating abundant hydroxyl radical through Fenton-type reaction between Cu2+ assistance glutathione depletion. Overloaded Ca2+ lead mitochondria injury thus enhance oxidative stress cells. Moreover, unbalanced transport channel caused further promote calcification necrosis, which generally defined ion-interference As result, synergistic Fenton-like dysfunction ROS generation performed. Therefore, TME-responsive based integration successfully established exhibits satisfactory efficiency than any peroxide.

Language: Английский

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Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2068 - 2098

Published: Feb. 8, 2021

Materials that respond to endogenous stimuli are being leveraged enhance spatiotemporal control in a range of biomedical applications from drug delivery diagnostic tools. The design materials undergo morphological or chemical changes response specific biological cues pathologies will be an important area research for improving efficacies existing therapies and imaging agents, while also promising developing personalized theranostic systems. Internal stimuli-responsive systems can engineered across length scales nanometers macroscopic signals such as enzymes, pH, glucose, ATP, hypoxia, redox signals, nucleic acids by incorporating synthetic bio-inspired moieties natural building blocks. This Review summarize mechanisms fabrication strategies used internal with focus on broad pathologies, including cancer, diabetes, vascular disorders, inflammation, microbial infections. We discuss observed challenges, future directions, clinical translation aspects these responsive materials.

Language: Английский

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