Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(38)
Published: Aug. 1, 2022
Abstract
The
intelligent
nanomachine
usually
has
a
control
center
to
carry
out
self‐regulation.
Unfortunately,
most
of
the
nanomaterials
for
chemodynamic
therapy
(CDT)
do
not
have
such
sense
and
process
chemical
or
biological
signals,
which
greatly
weakens
selectivity
efficiency
CDT.
To
address
this
problem,
here
an
was
constructed
with
DNAzyme
logic
gate
as
center,
metal
organic
framework
actuator.
well‐designed
showed
enhanced
killing
effect
on
cancer
cells
but
posed
no
harm
normal
cells,
acquiring
better
than
clinical
chemotherapy
drugs
(doxorubicin
cisplatin).
best
our
knowledge,
is
first
reported
cell‐specific
CDT
by
guidance
gate.
Our
work
highlights
great
potential
DNAzymes
in
response
networks,
extends
implementation
nanomachines
precision
medicine.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
13(4), P. 863 - 889
Published: Nov. 29, 2021
Applying
Fenton
chemistry
in
the
tumor
microenvironment
(TME)
for
cancer
therapy
is
most
significant
feature
of
chemodynamic
(CDT).
Owing
to
mild
acid
and
overexpressed
H2O2
TME,
more
cytotoxic
hydroxyl
radicals
(˙OH)
are
generated
cells
via
Fenton-like
reactions.
Without
external
stimulus
drug
resistance
generation,
reactive
oxygen
species
(ROS)-mediated
CDT
exhibits
a
specific
desirable
anticancer
effect
has
been
seen
as
promising
strategy
therapy.
However,
optimizing
treatment
efficiency
TME
still
challenging
because
limited
catalytic
agents
strong
antioxidant
capacity
TME.
Hence,
scientists
trying
their
best
design
fabricate
many
with
excellent
activity
remodeling
optimal
CDT.
In
this
perspective,
latest
progress
discussed,
some
representative
examples
presented.
Consequently,
strategies
further
guided
by
provided.
Most
importantly,
several
feasible
ways
developing
future
offered
reference.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
11(2)
Published: Nov. 9, 2021
Abstract
Traditional
tumor
treatments,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
and
photothermal
are
developed
used
to
treat
different
types
of
cancer.
Recently,
chemodynamic
therapy
(CDT)
has
been
emerged
as
a
novel
cancer
therapeutic
strategy.
CDT
utilizes
Fenton
or
Fenton‐like
reaction
generate
highly
cytotoxic
hydroxyl
radicals
(•OH)
from
endogenous
hydrogen
peroxide
(H
2
O
)
kill
cells,
which
displays
promising
potentials
for
treatment.
However,
the
low
catalytic
efficiency
off‐target
side
effects
limit
biomedical
application
CDT.
In
this
regard,
various
strategies
implemented
potentiate
against
tumor,
retrofitting
microenvironment
(e.g.,
increasing
H
level,
decreasing
reductive
substances,
reducing
pH),
enhancing
nanocatalysts,
other
strategies.
This
review
aims
summarize
development
these
recent
progresses
nanocatalyst‐mediated
antitumor
application.
The
future
trend
challenges
also
discussed.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(11), P. 4786 - 4827
Published: Jan. 1, 2022
Multicharged
cyclodextrin
(CD)
supramolecular
assemblies,
including
those
based
on
positively/negatively
charged
modified
mono-6-deoxy-CDs,
per-6-deoxy-CDs,
and
random
2,3,6-deoxy-CDs,
as
well
parent
CDs
binding
guests,
have
been
extensively
applied
in
chemistry,
materials
science,
medicine,
biological
catalysis,
other
fields.
In
this
review,
we
primarily
focus
summarizing
the
recent
advances
encapsulating
especially
construction
process
of
assemblies
their
applications.
Compared
with
uncharged
CDs,
multicharged
display
remarkably
high
antiviral
antibacterial
activity
efficient
protein
fibrosis
inhibition.
Meanwhile,
can
interact
oppositely
dyes,
drugs,
polymers,
biomacromolecules
to
achieve
effective
encapsulation
aggregation.
Consequently,
CD
show
great
advantages
improving
drug-delivery
efficiency,
luminescence
properties
materials,
molecular
recognition
imaging,
toughness
hydrogels,
addition
enabling
multistimuli-responsive
assemblies.
These
features
are
anticipated
not
only
promote
development
CD-based
chemistry
but
also
contribute
rapid
exploitation
these
diverse
interdisciplinary
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(40)
Published: July 30, 2022
Abstract
Cuproptosis
is
a
very
newly
recognized
regulated
cell
death
modality
that
distinct
from
known
mechanisms
and
shows
enormous
prospect
in
cancer
treatment.
However,
its
efficacy
copper‐dependent
restricted
by
strictly
copper
metabolism.
Herein,
novel
copper/iron
hybrid
hollow
amorphous
metal
organic
framework
(HaMOF)
developed
as
an
oxidative
stress
amplifier
metabolic
disrupter
for
synergistic
cuproptosis/ferroptosis/apoptosis
anticancer
therapy.
The
HaMOF
fabricated
Cu
2+
,
3,3′‐dithiobis(propionohydrazide)
Fe
3+
via
unsaturated
coordination‐etching
integration
strategy,
then
doxorubicin
loaded
followed
surface
decoration
with
hyaluronan.
obtained
DOX@Fe/CuTH
exhibits
tumor
microenvironment‐triggered
catalytic
therapeutic
property,
wherein
it
can
amplify
cellular
simultaneously
boosting
H
2
O
production
depleting
glutathione.
Moreover,
cause
mitochondrial
dysfunction
downregulate
the
expressions
of
transporter
ATP7A
iron
FPN
1,
thereby
leading
to
disorders
high
retentions
cytoplasm
•OH
generation.
overloaded
lipoylated
protein
dihydrolipoamide
S‐acetyltransferase
aggregation
lead
cuproptosis.
Collectively,
both
augmented
induce
potent
ferroptosis,
which
synergizes
cuproptosis
DOX‐mediated
apoptosis
efficiently
suppress
growth.
This
bimetallic
nanoplatform
provides
new
paradigm
boost
cuproptosis‐related
therapies.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(21)
Published: July 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
