Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(24), P. 9491 - 9497
Published: Feb. 26, 2020
Abstract
Chaos
and
the
natural
evolution
of
tumor
systems
can
lead
to
failure
therapies.
Herein,
we
demonstrate
that
iridium
oxide
nanoparticles
(IrO
x
)
possess
acid‐activated
oxidase
peroxidase‐like
functions
wide
pH‐dependent
catalase‐like
properties.
The
integration
glucose
(GOD)
unlocked
peroxidase
activities
IrO
by
production
gluconic
acid
from
GOD
catalysis
in
cancer
cells,
produced
H
2
O
was
converted
into
compensate
its
consumption
owing
function
nanozyme,
thus
resulting
continual
self‐supply
substrates
generate
superoxide
anion
hydroxyl
radical.
Moreover,
constantly
consume
glutathione
(GSH)
self‐cyclic
valence
alternation
Ir
IV
III
.
These
cascade
reactions
a
“butterfly
effect”
initial
starvation
therapy
subsequent
pressure
multiple
reactive
oxygen
species
(ROS)
completely
break
self‐adaption
cells.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(21)
Published: Aug. 16, 2020
As
an
essential
trace
element
in
the
human
body,
transitional
metal
copper
(Cu)
ions
are
bioactive
components
within
body
featuring
dedicated
biological
effects
such
as
promoting
angiogenesis
and
influencing
lipid/glucose
metabolism.
The
recent
substantial
advances
of
nanotechnology
nanomedicine
promote
emerging
distinctive
Cu-involved
biomaterial
nanoplatforms
with
intriguing
theranostic
performances
biomedicine,
which
originated
from
Cu
species
physiochemical
attributes
Cu-composed
nanoparticles.
Based
on
very-recent
significant
progresses
nanotheranostics,
this
work
highlights
discusses
principles,
progresses,
prospects
elaborate
design
rational
construction
functional
for
a
diverse
array
biomedical
applications,
including
photonic
nanomedicine,
catalytic
nanotherapeutics,
antibacteria,
accelerated
tissue
regeneration,
bioimaging.
engineering
Cu-based
nanocomposites
synergistic
nanotherapeutics
is
also
exemplified,
followed
by
revealing
their
intrinsic
biosafety
revolutionizing
clinical
translation.
Finally,
underlying
critical
concerns,
unresolved
hurdles,
future
uses
analyzed
outlook
provided.
By
entering
"Copper
Age,"
these
nanotherapeutic
modalities
expected
to
find
more
broad
applications
preclinical
phases,
despite
current
research
developments
still
being
infancy.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(52), P. 21751 - 21757
Published: Dec. 18, 2020
Although
more
attention
has
been
attracted
to
the
therapy
based
on
reactive
oxygen
species
(ROS)
for
tumor
in
recent
years,
such
as
photodynamic
and
chemodynamic
therapy,
limited
ROS
production
rate
leads
their
poor
treatment
effect
owing
relatively
low
content
of
O2
H2O2
microenvironments,
confined
light
penetration
depth,
strict
Fenton
reaction
conditions
(pH
3-4),
so
on.
Therefore,
it
is
urgent
explore
new
agents
with
highly
efficient
generation
capacity.
Herein,
we
first
prepared
phospholipid
coated
Na2S2O8
nanoparticles
(PNSO
NPs)
situ
generating
Na+
S2O82-
through
gradual
degradation,
which
can
then
be
changed
toxic
•SO4-
(a
novel
reported
ROS)
•OH
regardless
amount
pH
value
microenvironment
(TME).
As
a
large
Na+,
PNSO
NPs
bypass
ion
transport
rules
cells
endocytosis
deliver
amounts
into
cells,
resulting
surge
osmolarity
rapid
cell
rupture
lysis.
Osmotic
pressure
induced
by
will
further
lead
an
unusual
manner
death:
caspase-1-related
pyroptosis.
Moreover,
all
above
effects
cause
high
immunogenic
death,
regulate
immunosuppressed
TME,
activate
systemic
antitumor
immune
responses
combat
metastasis
recurrence.
We
believe
potential
agents,
this
work
broaden
thinking
exploring
nanodrugs.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12567 - 12603
Published: Aug. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(24), P. 9491 - 9497
Published: Feb. 26, 2020
Abstract
Chaos
and
the
natural
evolution
of
tumor
systems
can
lead
to
failure
therapies.
Herein,
we
demonstrate
that
iridium
oxide
nanoparticles
(IrO
x
)
possess
acid‐activated
oxidase
peroxidase‐like
functions
wide
pH‐dependent
catalase‐like
properties.
The
integration
glucose
(GOD)
unlocked
peroxidase
activities
IrO
by
production
gluconic
acid
from
GOD
catalysis
in
cancer
cells,
produced
H
2
O
was
converted
into
compensate
its
consumption
owing
function
nanozyme,
thus
resulting
continual
self‐supply
substrates
generate
superoxide
anion
hydroxyl
radical.
Moreover,
constantly
consume
glutathione
(GSH)
self‐cyclic
valence
alternation
Ir
IV
III
.
These
cascade
reactions
a
“butterfly
effect”
initial
starvation
therapy
subsequent
pressure
multiple
reactive
oxygen
species
(ROS)
completely
break
self‐adaption
cells.
