Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

---

Nanozymes: Activity origin, catalytic mechanism, and biological application

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 448, P. 214170 - 214170

Published: Aug. 26, 2021

Language: Английский

---

Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

---

Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Language: Английский

---

Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101076 - 101076

Published: Jan. 14, 2021

Language: Английский

---

Guiding Transition Metal‐Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi‐Enzymatic Activities for Intensive Chemodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 5, 2021

Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by the poor catalytic efficiency nanozymes, insufficient endogenous hydrogen peroxide (H2 O2 ) content, and its off-target consumption. Herein, authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities, that is, enhancement superoxide dismutase (SOD)-like peroxidase (POD)-like activities inhibition catalase (CAT)-like activity. PHMZCO-AT as H2 homeostasis disruptor promotes evolution restrains elimination to achieve intensive NCDT. SOD-like activity catalyzes anion (O2•- into in tumor region. The suppression CAT depletion glutathione largely weaken decomposition O. Elevated is then catalyzed downstream POD-like generate toxic hydroxyl radicals, further inducing apoptosis death. T1 -weighted magnetic resonance imaging X-ray computed tomography are also achieved using due existence paramagnetic Mn2+ high attenuation ability elemental Zr, permitting vivo tracking therapeutic process. This work presents typical paradigm NCDT efficacy regulating nanozymes perturb homeostasis.

Language: Английский

---

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

---

Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Materials Today, Journal Year: 2021, Volume and Issue: 44, P. 211 - 228

Published: Jan. 14, 2021

Language: Английский

---

Na₂S₂O₈ Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(52), P. 21751 - 21757

Published: Dec. 18, 2020

Although more attention has been attracted to the therapy based on reactive oxygen species (ROS) for tumor in recent years, such as photodynamic and chemodynamic therapy, limited ROS production rate leads their poor treatment effect owing relatively low content of O2 H2O2 microenvironments, confined light penetration depth, strict Fenton reaction conditions (pH 3-4), so on. Therefore, it is urgent explore new agents with highly efficient generation capacity. Herein, we first prepared phospholipid coated Na2S2O8 nanoparticles (PNSO NPs) situ generating Na+ S2O82- through gradual degradation, which can then be changed toxic •SO4- (a novel reported ROS) •OH regardless amount pH value microenvironment (TME). As a large Na+, PNSO NPs bypass ion transport rules cells endocytosis deliver amounts into cells, resulting surge osmolarity rapid cell rupture lysis. Osmotic pressure induced by will further lead an unusual manner death: caspase-1-related pyroptosis. Moreover, all above effects cause high immunogenic death, regulate immunosuppressed TME, activate systemic antitumor immune responses combat metastasis recurrence. We believe potential agents, this work broaden thinking exploring nanodrugs.

Language: Английский

---

Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(50), P. 22537 - 22543

Published: Aug. 28, 2020

Redox homeostasis is one of the main reasons for reactive oxygen species (ROS) tolerance in hypoxic tumors, limiting ROS-mediated tumor therapy. Proposed herein a redox dyshomeostasis (RDH) strategy based on nanoplatform, FeCysPW@ZIF-82@CAT Dz, to disrupt homeostasis, and its application improve Once endocytosed by cells, catalase DNAzyme (CAT Dz) loaded zeolitic imidazole framework-82 (ZIF-82@CAT shell can be degraded into Zn2+ as cofactors CAT Dz mediated silencing electrophilic ligands glutathione (GSH) depletion under hypoxia, both which lead intracellular RDH H2 O2 accumulation. These "disordered" cells show reduced resistance ROS are effectively killed ferrous cysteine-phosphotungstate (FeCysPW) induced chemodynamic therapy (CDT). In vitro vivo data demonstrate that pH/hypoxia/H2 triple stimuli responsive nanocomposite efficiently kill tumors. Overall, provides new way thinking about treatment

Language: Английский

---