Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(42), P. 6351 - 6354
Published: Jan. 1, 2023
An
N-heterocyclic
carbene
(NHC)
catalyzed
enantio-
and
diastereoselective
[12+2]
cycloaddition
is
disclosed
to
rapidly
construct
sophisticated
molecules
bearing
a
tricyclic
core
morpholine
moiety.
The
success
of
our
reaction
relies
on
the
NHC-catalyzed
remote
sp3
(C-H)
bond
activation
5H-benzo[a]pyrrolizine-3-carbaldehyde
under
oxidative
conditions.
Preliminary
studies
revealed
that
products
exhibit
superior
in
vitro
bioactivities
against
two
plant
pathogens
commercial
Bismerthiazol
(BT)
Thiodiazole
Copper
(TC).
Chemistry - A European Journal,
Journal Year:
2022,
Volume and Issue:
29(4)
Published: Oct. 7, 2022
N-Heterocyclic
carbene
(NHC)
catalysis
is
a
by
now
consolidated
organocatalytic
platform
for
number
of
synthetic
(asymmetric)
transformations
via
diverse
reaction
modes/intermediates.
In
addition
to
the
typical
umpolung
processes
involving
acyl
anion/homoenolate
equivalent
species,
implementation
protocols
under
oxidative
conditions
greatly
expands
possibilities
this
methodology.
Oxidative
NHC-catalysis
allows
and
oxygenative
through
specific
manipulations
Breslow-type
species
depending
upon
oxidant
used
(external
or
O
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(9), P. 6926 - 6935
Published: April 18, 2024
The
synthesis
of
N–N
axial
compounds
containing
aromatic
acyl
amides
using
common
acylation
reagents
remains
challenging.
We
describe
a
highly
atropenantioselective
N-aminoindoles
axes.
A
chiral
cyclic
isothiourea
is
used
as
the
sole
organic
catalyst
in
transformation
N-acylation
reaction.
Aroyl
chlorides
have
been
to
construct
atropisomeric
through
N-acylation.
N-aminoindole
products,
which
bear
stereogenic
axes,
were
synthesized
with
high
yields
and
enantioselectivities.
Some
enantiopure
products
exhibited
promising
antibacterial
activities
against
plant
pathogens.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1824 - 1842
Published: Jan. 1, 2024
In
this
review,
we
briefly
summarize
the
recent
research
progress
in
enantioselective
higher-order
cycloadditions,
focusing
on
preparation
of
medium-sized
and
multicyclic
chiral
molecules
by
metal-free
catalysis.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(14), P. 5037 - 5043
Published: Jan. 1, 2021
Covalent
activation
of
heteroatoms
enabled
by
N-heterocyclic
carbene
(NHC)
organic
catalysts
for
enantioselective
reactions
is
evaluated
and
summarized
in
this
review.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 112 - 112
Published: Jan. 7, 2023
Dental
caries
is
a
biofilm-mediated
disease
that
represents
worldwide
oral
health
issue.
Streptococcus
mutans
has
been
ascertained
as
the
main
cariogenic
pathogen
responsible
for
human
dental
caries,
with
high
ability
to
form
biofilms,
regulated
by
quorum
sensing.
Diarylureas
represent
class
of
organic
compounds
show
numerous
biological
activities,
including
antimicrobial
one.
Two
small
molecules
belonging
this
class,
specifically
diphenylureas,
BPU
(1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea)
and
DMTU
(1,3-di-m-tolyl-urea),
showed
interesting
results
in
studies
regarding
activity
against
bacterium
S.
mutans.
Since
there
are
not
many
antimicrobials
used
prevention
treatment
further
on
these
two
other
diarylureas
may
be
useful
design
new
effective
agents
generally
low
cytotoxicity.
Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(11), P. 2709 - 2762
Published: Sept. 18, 2021
Abstract
The
wide
occurrence
of
pyrroles
in
natural
products
and
pharmaceuticals
calls
for
novel
synthetic
methodologies
the
efficient
synthesis
enantiopure
pyrroles.
Owing
to
their
highly
reactive
nature
wide‐ranging
chemical
landscape,
enormous
efforts
have
been
dedicated
not
only
but
also
development
reactions
using
them
as
a
platform
utilization
stereocontrolled
diverse
molecules.
In
sharp
contrast
extensive
studies
devoted
toward
indoles,
asymmetric
functionalization
was
less
explored.
Nevertheless,
attractiveness
selective
access
product
analogy,
medicinally
useful
architectures
witnessed
tremendous
growth
last
few
years.
Their
effectiveness
under
both
metal‐
organocatalytic
conditions
currently
encompasses
vast
majority
enantioselective
transformations.
This
review
article
aims
present
comprehensive
overview
catalytic
C−H
well
N−H
reported
from
2010
now.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(13), P. 7781 - 7788
Published: June 16, 2022
Disclosed
here
is
a
catalytic
strategy
for
asymmetric
access
to
chiral
tetrasubstituted
silicon-stereogenic
silanes.
Our
reaction
starts
with
(covalently)
symmetric
silane
bearing
two
aldehyde
moieties
as
the
substrate.
Single-crystal
structural
analysis
shows
that
substrate
exists
racemate
of
conformational
enantiomers
because
presence
Si/O
weak
interaction.
Mechanistic
studies
assisted
by
DFT
calculation
indicate
can
readily
isomerize
each
other,
and
one
favorably
activated
N-heterocyclic
carbene
catalyst
via
an
overall
desymmetrization
process
eventually
afford
optically
enriched
silanes
products.
silanes'
products
be
transformed
diverse
set
silicon
stereogenic
functional
molecules.
