Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

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Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(51), P. 23438 - 23447

Published: Dec. 13, 2022

Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in the primary difference between normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) healing of rats through integrating metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species modulate oxidative stress microenvironment wounds, leads natural transition from proliferation phase. Impressively, efficacy one-time-applied was comparable that human epidermal growth factor Gel, widely used drug various treatments. Such effective, safe, convenient meet complex demands.

Language: Английский

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Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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A Valence‐Engineered Self‐Cascading Antioxidant Nanozyme for the Therapy of Inflammatory Bowel Disease

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: April 22, 2022

Abstract Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly effective disease option. Nanozymes with multiple antioxidant activities can cope the diverse ROS environment. However, lack of design strategies and limitation negative correlation for nanozymes hindered their development. To overcome these difficulties, here we used ZnMn 2 O 4 as model to explore role Mn valency at octahedral site via valence‐engineered strategy, found that its are positively correlated content 4+ . Therefore, through this self‐cascading nanozyme LiMn was constructed, efficacy verified cellular level in an inflammatory bowel model. This work not only provides guidance nanozymes, but also broadens biomedical application potential nanozymes.

Language: Английский

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Preparation of amorphous MOF based biomimetic nanozyme with high laccase- and catecholase-like activity for the degradation and detection of phenolic compounds

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 434, P. 134677 - 134677

Published: Jan. 13, 2022

Language: Английский

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Construction of biomimetic nanozyme with high laccase- and catecholase-like activity for oxidation and detection of phenolic compounds

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 429, P. 128404 - 128404

Published: Feb. 2, 2022

Language: Английский

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Iron single-atom anchored N-doped carbon as a ‘laccase-like’ nanozyme for the degradation and detection of phenolic pollutants and adrenaline

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 425, P. 127763 - 127763

Published: Nov. 14, 2021

Language: Английский

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Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 25, 2021

Abstract The activity of nanomaterials (NMs) in catalytically scavenging superoxide anions mimics that dismutase (SOD). Although dozens NMs have been demonstrated to possess such activity, the underlying principles are unclear, hindering discovery as novel SOD mimics. In this work, we use density functional theory calculations study thermodynamics and kinetics catalytic processes, develop two principles, namely, an energy level principle adsorption principle, for activity. first quantitatively describes role intermediate frontier molecular orbital transferring electrons catalysis. second one competition between desired reaction undesired side reactions. ability predict SOD-like activities metal-organic frameworks were verified by experiments. Both can be easily implemented computer programs computationally screen with intrinsic

Language: Английский

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Ultra‐Small High‐Entropy Alloy Nanoparticles: Efficient Nanozyme for Enhancing Tumor Photothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 30, 2023

High-entropy alloys nanoparticles (HEANPs) are receiving extensive attention due to their broad compositional tunability and unlimited potential in bioapplication. However, developing new methods prepare ultra-small high-entropy alloy (US-HEANPs) faces severe challenges owing intrinsic thermodynamic instability. Furthermore, there few reports on studying the effect of HEANPs tumor therapy. Herein, fabricated PtPdRuRhIr US-HEANPs act as bifunctional nanoplatforms for highly efficient treatment tumors. The engineered by universal metal-ligand cross-linking strategy. This simple scalable strategy is based aldol condensation organometallics form target US-HEANPs. synthesized exhibit excellent peroxidase-like (POD-like) activity can catalyze endogenous hydrogen peroxide produce toxic hydroxyl radicals. possess a high photothermal conversion converting 808 nm near-infrared light into heat energy. In vivo vitro experiments demonstrated that under synergistic POD-like action, effectively ablate cancer cells treat It believed this work not only provides perspective fabrication HEANPs, but also opens nanozymes research direction biomedical application.

Language: Английский

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Photosensitized Peroxidase Mimicry at the Hierarchical 0D/2D Heterojunction‐Like Quasi Metal‐Organic Framework Interface for Boosting Biocatalytic Disinfection

Small, Journal Year: 2022, Volume and Issue: 18(20)

Published: April 18, 2022

Abstract Metal‐organic frameworks (MOFs) are a versatile toolbox for the bioinspired design of nanozymes antibacterial applications and beyond, however, designing nanozyme by hierarchical quasi‐MOF scheme remains largely unpracticed. This work exemplifies preferential structure‐activity correlation bimetallic (Q‐MOF Ce0.5 ) among three series MOF‐derived peroxidase (POD) mimics. The biomimetic nanosheets accommodate both oxygen vacancy‐coupled multivalent redox cycles photosensitive energy band layout, benefiting from heterojunction‐like 0D/2D interface featuring isolated nodes‐derived CeOCu sites upon 2D decarboxylated MOF scaffold. These integrated unique merits enable POD‐like Q‐MOF to generate sustained reactive species effectively eradicate surface‐adhered bacteria under visible light, resulting in significant inactivation Escherichia coli (99.74 %) Staphylococcus aureus (99.35%) vitro, potent disinfection skin wounds vivo safe on‐demand manners. It is hoped that this can intensify interventions against microbial world.

Language: Английский

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