In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(21)

Published: Nov. 29, 2022

Abstract Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn increasing attention, bringing great opportunities for clinical application. Here, two targeting strategies four main organelles (mitochondria, lysosome, endoplasmic reticulum, and nucleus), including molecule‐ nanomaterial (inorganic nanoparticles, micelles, organic polymers, others)‐based delivery or therapeutic strategies, are summarized. Phototherapy, chemotherapy, radiotherapy, immunotherapy, “all‐in‐one” combination among the covered in detail. Such materials constructed based on specific properties relevant mechanisms of organelles, enabling elimination tumors by inducing dysfunction corresponding destroying structures. The challenges faced organelle‐targeting therapies also Looking forward, paradigm with enhanced efficacy compared to current approaches is envisioned.

Language: Английский

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An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(33)

Published: April 25, 2023

Abstract Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on biological microenvironment because it difficult produce type I and II reactive oxygen species (ROS) simultaneously. Herein, an electron‐rich anion‐ π + AIEgen Pys‐QM‐TT reported, which capable generating ROS realizing near‐infrared fluorescence imaging synchronously. In rational design photosensitizer, strong electron‐donating triphenylamine unit, π‐bridge thiophene electron‐withdrawing pyridinium salt unit can enhance D–π–A behavior, thereby improving intramolecular charge transfer extending wavelength. Meanwhile, powerful supposed reduce ∆ E S‐T promote intersystem crossing processes, thus increasing generation ROS. addition, negatively charged anion group provides environment for excited so as electron generate Therefore, not only simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections ablate tumor tissue by promoting cell apoptosis, inhibiting proliferation anti‐angiogenesis.

Language: Английский

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Activatable nano-photosensitizers for precise photodynamic cancer therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 493, P. 215324 - 215324

Published: July 10, 2023

Language: Английский

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Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation

Nature Catalysis, Journal Year: 2023, Volume and Issue: 6(8), P. 729 - 739

Published: Aug. 10, 2023

Language: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

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Self‐Reinforced Bimetallic Mito‐Jammer for Ca²⁺ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified metal‐organic frameworks (MOF). After cellular, dissociates CaO Cu 2+ tumor microenvironment. The exposed further yields hydrogen (H O Ca weakly acidic environment to strengthen ‐based Fenton‐like reaction. Furthermore, combination chemodynamic therapy overload exacerbates ROS storms mitochondrial damage, resulting downregulation intracellular adenosine triphosphate (ATP) levels blocking Cu‐ATPase sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic death suppresses metastasis simultaneously. study presents multivariate model for revolutionizing mitochondria relying continuous retention ions boost cuproptosis/immunotherapy cancer.

Language: Английский

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Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 6, 2024

Abstract Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and interference from Tumor Microenvironment (TME). Here we show a TME-activated situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction upregulated GSH TME, C 3 N 4 -Mn obtained TME with Mn atomically coordinated into cavity nanosheets. This overcomes toxicity random distribution catalyst release healthy tissues. Based Ligand-to-Metal charge transfer (LMCT) process, exhibit enhanced absorption red-light region. Thereby, water-splitting process is induced under 660 nm irradiation, which initiates O 2 -independent generation highly toxic hydroxyl radical (·OH) cancer-specific Subsequently, ·OH-initiated lipid peroxidation demonstrated to devote effective cancer cell death. The synthesized facilitate precise conversion inert H reactive ·OH, facilitates female mice. strategy achieves therapy, not only avoiding but also overcoming tumor hypoxia.

Language: Английский

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Donor–Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR‐II Emission

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 25, 2024

Abstract Photosensitizers (PSs) with aggregation‐induced emission (AIE) characteristics are competitive candidates for bioimaging and therapeutic applications. However, their short wavelength nonspecific organelle targeting hinder effectiveness. Herein, a donor–acceptor modulation approach is reported to construct series of ionic AIE photosensitizers enhanced photodynamic therapy (PDT) outcomes fluorescent in the second near‐infrared (NIR‐II) window. By employing dithieno[3,2‐b:2′,3′‐d]pyrrole (DTP) indolium (In) as strong donor acceptor, respectively, compound DTP‐In exhibits substantial redshift absorption reach NIR‐II region. The reduced energy gap between singlet triplet states also increases reactive oxygen species (ROS) generation rate. Further, can self‐assemble aqueous solutions, forming positively charged nanoaggregates, which superior conventional encapsulated nanoparticles cellular uptake mitochondrial targeting. Consequently, aggregates show efficient ablation 4T1 cancer cells outstanding tumor theranostic vivo under 660 nm laser irradiation. This work highlights potential molecular engineering PSs multiple functionalities, thereby facilitating development more effective strategies therapy.

Language: Английский

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Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 19, 2024

The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction information exchange. Therefore, disrupting its structure or impairing functions can potentially cause irreversible damage. Presently, the tumor recognized as promising therapeutic target for various treatment methods. Given extensive research focused on membranes, it both necessary timely to discuss these developments, from materials design specific biomedical applications. This review covers treatments based functional targeting membrane, ranging well-known membrane-anchoring photodynamic therapy recent lysosome-targeting chimaeras protein degradation. diverse mechanisms are introduced in following sections: phototherapy, self-assembly situ biosynthesis degradation proteins by chimeras. In each section, we outline conceptual general derived numerous studies, emphasizing representative examples understand advancements draw inspiration. Finally, some challenges future directions membrane-targeted our perspective. aims engage multidisciplinary readers encourage researchers related fields advance fundamental theories practical applications membrane-targeting agents.

Language: Английский

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Unveiling the potential of HKUST-1: synthesis, activation, advantages and biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2670 - 2690

Published: Jan. 1, 2024

HKUST-1 represents a promising biomaterial, functioning not only as drug carrier but also releasing bioactive copper ions, thereby demonstrating exceptional antitumor, antibacterial, and wound healing properties.

Language: Английский

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