Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 16, 2024
Abstract
Early
diagnosis
and
intervention
of
Alzheimer’s
disease
(AD)
are
particularly
important
to
delay
the
pathological
progression.
Although
fluorescent
probes
have
been
widely
employed
for
investigating
diagnosing
AD,
their
biological
applications
significantly
restricted
due
low
penetration
ability
blood–brain
barrier
(BBB)
in
vivo.
In
this
study,
we
reported
first
Golgi-targeted
two-photon
(TP)
probe,
DCM-DH,
detecting
viscosity
Golgi
apparatus.
The
probe
was
rationally
designed
exhibit
superior
analytical
performance
including
high
sensitivity,
specific
Golgi-targeting,
efficient
BBB
ability,
deep
tissue
(247
μm)
brains
AD
model
mice.
Using
demonstrated
that
fluorescence
intensity
human
liver
cancer
cell
(HepG2
cells)
higher
than
normal
(LO2
cells),
brain
mice
increased
significantly.
We
anticipate
competent
tool
could
be
easily
extended
other
biomarkers
fundamental
research
on
detrimental
disease.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(30)
Published: May 8, 2024
Abstract
Photodynamic
therapy
is
an
anti‐cancer
treatment
that
requires
illumination
of
photosensitizers
to
induce
local
cell
death.
Current
near‐infrared
organic
are
built
from
large
and
non‐modular
structures
cannot
be
tuned
improve
safety
minimize
off‐target
toxicity.
This
work
describes
a
novel
chemical
platform
generate
enzyme‐activatable
photosensitizers.
We
optimized
the
Se‐bridged
hemicyanine
scaffold
include
caging
groups
biocompatible
moieties,
generated
cathepsin‐triggered
for
effective
ablation
human
glioblastoma
cells.
Furthermore,
we
demonstrated
hemicyanines
safe
microtumors
in
vivo,
creating
new
avenues
design
targeted
photodynamic
agents.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 16, 2024
Abstract
Early
diagnosis
and
intervention
of
Alzheimer’s
disease
(AD)
are
particularly
important
to
delay
the
pathological
progression.
Although
fluorescent
probes
have
been
widely
employed
for
investigating
diagnosing
AD,
their
biological
applications
significantly
restricted
due
low
penetration
ability
blood–brain
barrier
(BBB)
in
vivo.
In
this
study,
we
reported
first
Golgi-targeted
two-photon
(TP)
probe,
DCM-DH,
detecting
viscosity
Golgi
apparatus.
The
probe
was
rationally
designed
exhibit
superior
analytical
performance
including
high
sensitivity,
specific
Golgi-targeting,
efficient
BBB
ability,
deep
tissue
(247
μm)
brains
AD
model
mice.
Using
demonstrated
that
fluorescence
intensity
human
liver
cancer
cell
(HepG2
cells)
higher
than
normal
(LO2
cells),
brain
mice
increased
significantly.
We
anticipate
competent
tool
could
be
easily
extended
other
biomarkers
fundamental
research
on
detrimental
disease.
