Applied Spectroscopy Reviews,
Journal Year:
2023,
Volume and Issue:
59(2), P. 224 - 246
Published: March 21, 2023
In
this
paper,
the
research
progress
of
surface-enhanced
Raman
spectroscopy
(SERS)
in
nervous
system
recent
years
is
reviewed.
Firstly,
current
status
neurotransmitter
testing
briefly
introduced,
and
advantages
SERS
detection
technology
are
proposed.
Secondly,
development
for
neurotransmitters
reviewed,
such
as
monoamines
amino
acids.
Thirdly,
used
to
detect
neurological
diseases
mainly
based
microdevices
further
introduced.
addition,
diagnostic
applications
malignant
tumors
analyzed.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(4), P. 2118 - 2126
Published: Jan. 18, 2023
Herein,
we
demonstrated
a
strategy
to
regulate
the
conductive
metal–organic
framework
(MOF)
surface,
by
conjugated
molecule
wires
for
selective
and
sensitive
determination
of
dopamine
(DA)
in
live
brain.
The
MOFs
were
decorated
at
carbon
fiber
electrode
deposited
Au
nanoleaves
as
upper
electric
transducer
provide
rich
electrocatalytic
sites
electron
transfer
neurochemicals
leading
greatly
enhanced
sensitivity
detection
neurochemicals.
On
other
hand,
molecular
wire,
4-(thiophen-3-ylethynyl)-benzaldehyde
(RP1),
was
synthesized
assembled
an
underlying
bridge
electrochemical
processes
MOF-based
electrode,
specifically
decreasing
reaction
Gibbs
free
energy
DA
oxidation,
thus
selectively
promoting
heterogeneous
from
MOF
layer
surface.
Owing
activity
present
microsensor
exhibited
high
selectivity
real-time
tracking
good
linear
relationship
range
0.004–0.4
μM
with
limit
1
nM.
Eventually,
this
functionalized
successfully
applied
vivo
monitoring
mouse
brains
Parkinson's
disease
(PD)
model.
results
indicated
that
levels
obviously
decreased
both
acute
subacute
PD
models.
Moreover,
level
strongly
depended
on
amount
uric
acid
(UA),
physiological
antioxidant,
which
rose
UA
lower
than
200
mg
kg–1
but
downregulated
again
after
treatment
higher
UA.
The
year
2024
marks
the
50th
anniversary
of
discovery
surface-enhanced
Raman
spectroscopy
(SERS).
Over
recent
years,
SERS
has
experienced
rapid
development
and
became
a
critical
tool
in
biomedicine
with
its
unparalleled
sensitivity
molecular
specificity.
This
review
summarizes
advancements
challenges
substrates,
nanotags,
instrumentation,
spectral
analysis
for
biomedical
applications.
We
highlight
key
developments
colloidal
solid
an
emphasis
on
surface
chemistry,
hotspot
design,
3D
hydrogel
plasmonic
architectures.
Additionally,
we
introduce
innovations
including
those
interior
gaps,
orthogonal
reporters,
near-infrared-II-responsive
properties,
along
biomimetic
coatings.
Emerging
technologies
such
as
optical
tweezers,
nanopores,
wearable
sensors
have
expanded
capabilities
single-cell
single-molecule
analysis.
Advances
analysis,
signal
digitalization,
denoising,
deep
learning
algorithms,
improved
quantification
complex
biological
data.
Finally,
this
discusses
applications
nucleic
acid
detection,
protein
characterization,
metabolite
monitoring,
vivo
spectroscopy,
emphasizing
potential
liquid
biopsy,
metabolic
phenotyping,
extracellular
vesicle
diagnostics.
concludes
perspective
clinical
translation
SERS,
addressing
commercialization
potentials
tissue
sensing
imaging.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(33)
Published: June 8, 2022
Gas-phase
surface-enhanced
Raman
scattering
(SERS)
remains
challenging
due
to
poor
analyte
affinity
SERS
substrates.
The
reported
use
of
capturing
probes
suffers
from
concurrent
inconsistent
signals
and
long
response
time
the
formation
multiple
potential
probe-analyte
interaction
orientations.
Here,
we
demonstrate
non-covalent
interactions
for
ring
complexation
boost
small
gas
molecules,
SO2
NO2
,
our
platform,
achieving
rapid
capture
multiplex
detection
down
100
ppm.
Experimental
in-silico
studies
affirm
stable
complex
formation,
kinetic
investigations
reveal
a
4-fold
faster
compared
without
capability.
By
synergizing
spectral
concatenation
support
vector
machine
regression,
achieve
91.7
%
accuracy
quantification
in
excess
CO2
mimicking
real-life
exhausts.
Our
platform
shows
immense
on-site
exhaust
air
quality
surveillance.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(6), P. 2779 - 2787
Published: Jan. 1, 2023
As
an
emerging
class
of
two-dimensional
(2D)
materials,
MBenes
show
enormous
potential
for
optoelectronic
applications.
However,
their
use
in
molecular
sensing
as
surface-enhanced
Raman
scattering
(SERS)-active
material
is
unknown.
Herein,
the
first
time,
we
develop
a
brand-new
high-performance
MBene
SERS
platform.
Ordered
vacancy-triggered
highly
sensitive
platform
with
outstanding
signal
uniformity
based
on
2D
Mo4/3B2
was
designed.
The
presented
superior
activity
to
most
semiconductor
substrates,
showing
remarkable
enhancement
factor
3.88
×
106
and
ultralow
detection
limit
1
10-9
M.
underlying
mechanism
revealed
from
systematic
experiments
density
functional
theory
calculations
that
ultrahigh
sensitivity
derived
efficient
photoinduced
charge
transfer
process
between
substrates
adsorbed
molecules.
abundant
electronic
states
near
Fermi
level
enables
its
by
100
000
times
higher
than
bulk
MoB.
Consequently,
could
accurately
detect
various
trace
chemical
analytes.
Moreover,
ordered
metal
vacancies
MBene,
uniform
sites
are
formed,
resulting
relative
standard
deviation
down
6.0%.
This
work
opens
up
new
horizon
which
holds
great
promise
field
sensing.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(21)
Published: March 26, 2024
Abstract
A
persistent
challenge
in
utilizing
Au
nanocrystals
for
surface‐enhanced
Raman
spectroscopy
(SERS)
lies
achieving
controllable
superstructures
that
maximize
SERS
performance.
Here,
a
novel
strategy
is
proposed
to
enhance
the
performance
by
precisely
adjusting
tip
arrangements
of
nanobipyramids
(BPs)
two‐dimensional
(2D)
superlattices
(SLs).
This
achieved
through
ligand‐exchange
BPs,
followed
liquid‐air
interfacial
assembly,
resulting
large‐area,
transferrable
SL
membranes.
The
key
controlling
arrangement
BPs
SLs
regulation
amount
free
ligands
added
during
self‐assembly,
which
allows
precise
formation
various
configurations
such
as
tilted
SLs,
tip‐on‐tip
and
tip‐to‐tip
SLs.
Among
these
configurations,
exhibit
highest
enhancement
factor
SERS,
reaching
an
impressive
value
1.95×10
8
,
with
uniform
consistent
signals
across
large
area.
experimental
findings
are
further
corroborated
simulations
using
finite
element
method.
study
establishes
efficient
method
engineering
microstructure
2D
composed
highlighting
importance
fine‐tuning
regulate
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(41), P. 14280 - 14289
Published: Oct. 6, 2022
The
redox
homeostasis
in
living
cells
is
greatly
crucial
for
maintaining
the
biological
function,
whereas
accurate
and
dynamic
detection
of
intracellular
states
still
remains
challenging.
Herein,
a
reversible
surface-enhanced
Raman
scattering
(SERS)
nanosensor
based
on
covalent
organic
frameworks
(COFs)
was
prepared
to
dynamically
monitor
processes
cells.
fabricated
by
modifying
redox-responsive
reporter
molecule,
2-Mercaptobenzoquione
(2-MBQ),
surface
gold
nanoparticles
(AuNPs),
followed
situ
coating
COFs
shell.
2-MBQ
molecules
can
repeatedly
quickly
undergo
reduction
oxidation
when
successively
treated
with
ascorbic
acid
(AA)
hypochlorite
(ClO–)
(as
models
reductive
oxidative
species,
respectively),
which
resulted
reciprocating
changes
SERS
spectra
at
900
cm–1.
construction
shell
provided
great
stability
anti-interference
capability,
thus
reliably
visualizing
dynamics
species
like
AA
ClO–
nanosensor.
Taken
together,
proposed
strategy
opens
up
prospects
investigate
signal
transduction
pathways
pathological
related
dynamics.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(46), P. 16006 - 16014
Published: Nov. 8, 2022
In
situ
rapid
detection
of
contaminants
in
environmental
water
is
crucial
for
protecting
the
ecological
environment
and
human
health;
however,
it
always
hindered
by
complexity
sample
matrices,
trace
content,
unknown
species.
Herein,
we
demonstrate
a
deep
learning-based
multicapturer
surface-enhanced
Raman
scattering
(SERS)
platform
on
plasmonic
nanocube
metasurfaces
multiplex
determination
organophosphorus
pesticides
(OPPs)
residues.
Poly(vinylpyrrolidone),
4-mercaptobenzoic
acid,
l-cysteine
are
assembled
Ag
nanocubes
(AgNCs)
act
as
capturers
to
chemically
define
OPPs.
Meanwhile,
OPPs-captured
AgNCs
efficiently
close
interparticle
distance
generate
metasurfaces,
guaranteeing
ultrasensitive
reproducible
SERS
analysis.
Furthermore,
strategically
combining
all
capturer–OPP
spectra,
comprehensive
"combined-SERS
spectra"
reconstructed
enhance
spectral
variations
each
OPP.
Based
combined-SERS
learning
model
trained
predict
OPPs,
which
significantly
improve
qualitative
quantitative
analysis
accuracy.
We
successfully
identified
multiple
OPPs
farmland,
river,
fishpond
using
this
strategy.
The
whole
procedure
requires
only
30
min,
including
sampling,
measurements,
analyses.
This
combination
with
algorithm
creates
reliable
analytical
strategy
target
molecules,
providing
potential
paradigm
shift
environment-related
research.
