Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(2)
Published: Jan. 27, 2023
Abstract
As
an
emerging
opportunity
to
expand
the
reactivity
repertoire
of
enzymes
achieve
unnatural
transformations
in
organic
synthesis,
enzyme
promiscuity
has
attracted
great
interest
recent
years.
The
combination
catalysis
and
photo‐/electro‐redox
which
can
benefit
from
both
exquisite
selectivity
unique
chemical
accessible
photo‐/electro‐chemistry
many
advantages,
such
as
new
reactivity,
high
enantioselectivity,
green
yields.
In
past
decades,
most
photoenzymatic
enzymatic
electrosynthesis
mainly
focused
on
exploiting
regenerated
cofactors
function
native
activity.
However,
developments
have
demonstrated
that
combining
unlock
asymmetric
reactions.
This
minireview
highlights
these
strategies
covers
literature
2016
date.
Furthermore,
future
development
direction
this
field
is
prospected.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(11), P. 2830 - 2848
Published: Jan. 1, 2023
Recent
advances
in
the
electrochemical
generation
of
1,3-dicarbonyl
radicals
from
C–H
bonds
and
their
mechanistic
insights
synthetic
applications
have
been
summarized.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(2), P. 1522 - 1531
Published: Jan. 3, 2024
The
development
of
a
reliable
strategy
for
stereodivergent
radical
reactions
that
allows
convenient
access
to
all
stereoisomers
homocoupling
adducts
with
multiple
stereogenic
centers
remains
an
unmet
goal
in
organic
synthesis.
Herein,
we
describe
dual-catalyzed
electrooxidative
C(sp3)–H/C(sp3)–H
complete
absolute
and
relative
stereocontrol
the
synthesis
molecules
contiguous
quaternary
stereocenters
general
predictable
manner.
reaction
is
achieved
by
synergistically
utilizing
two
distinct
chiral
catalysts
convert
identical
racemic
substrates
into
inherently
distinctive
reactive
intermediates,
dictate
enantioselective
addition,
allow
full
complement
stereoisomeric
products
via
simple
catalyst
permutation.
successful
execution
dual-electrocatalytic
programmed
activation
provides
significant
conceptual
advantage
will
serve
as
useful
foundation
further
research
cooperative
stereocontrolled
transformations
diversity-oriented
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Jan. 23, 2023
Electricity-driven
asymmetric
catalysis
is
an
emerging
powerful
tool
in
organic
synthesis.
However,
induction
so
far
has
mainly
relied
on
forming
strong
bonds
with
a
chiral
catalyst.
Asymmetry
induced
by
weak
interactions
catalyst
electrochemical
medium
remains
challenging
due
to
compatibility
issues
related
solvent
polarity,
electrolyte
interference,
etc.
Enabled
properly
designed
phase-transfer
strategy,
here
we
have
achieved
two
efficient
electricity-driven
catalytic
bromocyclization
processes
ion-pairing
interaction.
The
combined
use
of
and
phosphate
catalyst,
together
NaBr
as
the
bromine
source,
constitutes
key
advantages
over
conventional
chemical
oxidation
approach.
Synergy
multiple
events,
including
anodic
oxidation,
ion
exchange,
phase
transfer,
bromination,
inhibition
Br2
decomposition
NaHCO3,
proved
critical
success.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: March 9, 2023
Transition-metal
catalyzed
asymmetric
cyclization
of
1,6-enynes
has
emerged
as
a
powerful
method
for
the
construction
carbocycles
and
heterocycles.
However,
very
rare
examples
worked
under
electrochemical
conditions.
We
report
herein
Co-catalyzed
enantioselective
intramolecular
reductive
coupling
enynes
via
electrochemistry
using
H2O
hydride
source.
The
products
were
obtained
in
good
yields
with
high
regio-
enantioselectivities.
It
represents
progress
on
cobalt-catalyzed
transformation
general
substrate
scope.
DFT
studies
explored
possible
reaction
pathways
revealed
that
oxidative
by
LCo(I)
is
more
favorable
than
addition
or
other
pathways.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
highlights
organo-mediators
that
enable
electrochemical
reactions
via
outer-sphere
electron
transfer
(ET),
offering
advantages
such
as
availability,
tunability,
and
simplified
post-processing
compared
to
direct
electrolysis.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(15), P. 3929 - 3950
Published: Jan. 1, 2023
This
review
will
focus
on
the
electrochemical
synthesis
of
diversified
functionalized
oxindole
derivatives
through
C-S,
C-O,
C-C,
C-Se,
and
C-N
bond
formation
over
past
decade.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(41), P. 14911 - 14930
Published: Oct. 6, 2023
With
the
development
of
artificial
intelligence
(AI),
tailoring
methods
for
enzyme
engineering
have
been
widely
expanded.
Additional
protocols
based
on
optimized
network
models
used
to
predict
and
optimize
lipase
production
as
well
properties,
namely,
catalytic
activity,
stability,
substrate
specificity.
Here,
different
algorithms
prediction
reforming
lipase,
focusing
its
modification
cases
AI,
are
reviewed
in
terms
both
their
advantages
disadvantages.
Different
neural
networks
coupled
with
various
usually
applied
maximum
yield
by
optimizing
external
cultivations
production,
while
one
part
is
molecule
variations
affecting
properties
lipase.
However,
few
studies
directly
utilized
AI
engineer
structure
enzyme,
a
set
research
gaps
needs
be
explored.
Additionally,
future
perspectives
application
enzymes,
including
engineering,
deduced
help
redesign
enzymes
reform
new
functional
biocatalysts.
This
review
provides
horizon
developing
effective
innovative
tools
facilitating
applications
food
industry
biomass
conversion.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(23), P. 15771 - 15782
Published: Nov. 17, 2022
An
electrochemical
method
has
been
developed
to
synthesize
2,2-disubstituted
indolin-3-ones
under
mild
conditions.
A
series
of
nucleophiles
have
added
the
2-arylindole-3-ones,
generated
in
situ
metal-free
oxidative
dearomatization
2-arylindoles,
afford
3-carbonyl
indoles
with
heteroquaternary
centers
57-79%
yields.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(5), P. 2417 - 2424
Published: Jan. 1, 2023
The
photocatalytic
activity
of
TiO
2
in
the
simultaneous
oxidation
organic
molecules
and
H
production
is
optimized
via
crystal
phase
engineering
Ru
cocatalysts.
