Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(4), P. 108902 - 108902
Published: Aug. 9, 2023
Language: Английский
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(11), P. 2830 - 2848
Published: Jan. 1, 2023
Recent advances in the electrochemical generation of 1,3-dicarbonyl radicals from C–H bonds and their mechanistic insights synthetic applications have been summarized.
Language: Английский
Citations
80
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(2), P. 1522 - 1531
Published: Jan. 3, 2024
The development of a reliable strategy for stereodivergent radical reactions that allows convenient access to all stereoisomers homocoupling adducts with multiple stereogenic centers remains an unmet goal in organic synthesis. Herein, we describe dual-catalyzed electrooxidative C(sp3)–H/C(sp3)–H complete absolute and relative stereocontrol the synthesis molecules contiguous quaternary stereocenters general predictable manner. reaction is achieved by synergistically utilizing two distinct chiral catalysts convert identical racemic substrates into inherently distinctive reactive intermediates, dictate enantioselective addition, allow full complement stereoisomeric products via simple catalyst permutation. successful execution dual-electrocatalytic programmed activation provides significant conceptual advantage will serve as useful foundation further research cooperative stereocontrolled transformations diversity-oriented
Language: Английский
Citations
36
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Jan. 23, 2023
Electricity-driven asymmetric catalysis is an emerging powerful tool in organic synthesis. However, induction so far has mainly relied on forming strong bonds with a chiral catalyst. Asymmetry induced by weak interactions catalyst electrochemical medium remains challenging due to compatibility issues related solvent polarity, electrolyte interference, etc. Enabled properly designed phase-transfer strategy, here we have achieved two efficient electricity-driven catalytic bromocyclization processes ion-pairing interaction. The combined use of and phosphate catalyst, together NaBr as the bromine source, constitutes key advantages over conventional chemical oxidation approach. Synergy multiple events, including anodic oxidation, ion exchange, phase transfer, bromination, inhibition Br2 decomposition NaHCO3, proved critical success.
Language: Английский
Citations
37
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: March 9, 2023
Transition-metal catalyzed asymmetric cyclization of 1,6-enynes has emerged as a powerful method for the construction carbocycles and heterocycles. However, very rare examples worked under electrochemical conditions. We report herein Co-catalyzed enantioselective intramolecular reductive coupling enynes via electrochemistry using H2O hydride source. The products were obtained in good yields with high regio- enantioselectivities. It represents progress on cobalt-catalyzed transformation general substrate scope. DFT studies explored possible reaction pathways revealed that oxidative by LCo(I) is more favorable than addition or other pathways.
Language: Английский
Citations
24
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(41), P. 14911 - 14930
Published: Oct. 6, 2023
With the development of artificial intelligence (AI), tailoring methods for enzyme engineering have been widely expanded. Additional protocols based on optimized network models used to predict and optimize lipase production as well properties, namely, catalytic activity, stability, substrate specificity. Here, different algorithms prediction reforming lipase, focusing its modification cases AI, are reviewed in terms both their advantages disadvantages. Different neural networks coupled with various usually applied maximum yield by optimizing external cultivations production, while one part is molecule variations affecting properties lipase. However, few studies directly utilized AI engineer structure enzyme, a set research gaps needs be explored. Additionally, future perspectives application enzymes, including engineering, deduced help redesign enzymes reform new functional biocatalysts. This review provides horizon developing effective innovative tools facilitating applications food industry biomass conversion.
Language: Английский
Citations
20
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(15), P. 3929 - 3950
Published: Jan. 1, 2023
This review will focus on the electrochemical synthesis of diversified functionalized oxindole derivatives through C-S, C-O, C-C, C-Se, and C-N bond formation over past decade.
Language: Английский
Citations
19
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.
Language: Английский
Citations
1
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Direct benzylic C-H carboxylation stands as a high atom economy, efficient, and convenient route for the synthesis of valuable carboxylic acids, which are great significance in many pharmaceuticals bioactive molecules. However, inherent inertness both bonds carbon dioxide presents challenge further transformations. Herein, we report our efforts to overcome this obstacle via halide-promoted linear paired electrolysis generate various acids. Remarkably, process is transition-metal- base-free, making it environmentally benign cost-effective. Besides, suitable constructing wide range primary, secondary, tertiary acids under mild reaction conditions, demonstrating broad substrate scopes good functional group tolerance. Furthermore, protocol enables direct some drug molecules, including Flurbiprofen, Ibuprofen, Naproxen, facilitates late-stage modification complex compounds, showcasing practical application synthetic chemistry underscores its potential advance related compounds.
Language: Английский
Citations
1
Nanoscale, Journal Year: 2023, Volume and Issue: 15(5), P. 2417 - 2424
Published: Jan. 1, 2023
The photocatalytic activity of TiO 2 in the simultaneous oxidation organic molecules and H production is optimized via crystal phase engineering Ru cocatalysts.
Language: Английский
Citations
15
Molecular Catalysis, Journal Year: 2023, Volume and Issue: 546, P. 113248 - 113248
Published: May 17, 2023
Language: Английский
Citations
15