Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(6), P. 1561 - 1567
Published: Jan. 31, 2025
An
electrochemically
driven
Ugi-azide
reaction
was
established
via
C(sp3)-H
bond
activation
of
tertiary
amines
to
prepare
α-aminomethyl
tetrazoles
within
2.5
h
under
mild
conditions
with
remarkable
tolerance
various
functional
groups.
Besides,
this
electrochemical
strategy
not
only
obviated
the
needs
iodine,
metal,
and
exogenous
oxidant
but
possessed
potential
applicability
convenient
large-scale
synthesis.
Mechanistic
studies
indicated
both
alkyl
carbon-centered
radical
generated
at
anode
intramolecular
[3
+
2]
cycloaddition
are
key
factors
for
strategy.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(19), P. 13610 - 13621
Published: Sept. 11, 2023
An
electrophilic
spirocyclization
of
N-benzylacrylamides
with
N-halosuccinimides
(NXS)
as
the
halogenating
reagents
has
been
developed.
This
reaction
is
carried
out
at
room
temperature
under
simple
conditions
without
relying
on
metal
reagents,
photochemistry,
or
electrochemistry,
providing
a
fast
and
efficient
route
to
synthesize
wide
variety
4-halomethyl-2-azaspiro[4.5]decanes
satisfactory
yields.
The
approach
further
highlighted
through
gram-scale
synthesis
diverse
transformations
spiro
products.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(38), P. 7014 - 7019
Published: Sept. 18, 2023
Organoelectrophotocatalytic
generation
of
acyl
radicals
from
formamides
and
aldehydes
to
synthesize
acylated
3-CF3-2-oxindoles
has
been
developed.
This
protocol
features
a
monocatalytic
system
using
9,10-phenanthrenequinone
(PQ)
both
as
catalyst
hydrogen
atom
transfer
(HAT)
reagent,
which
avoids
the
use
an
external
HAT
metal
oxidant.
A
variety
have
obtained
in
satisfactory
yields
CF3-substituted
N-arylacrylamides
via
tandem
radical
cyclization.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(14), P. 3585 - 3590
Published: Jan. 1, 2023
An
organophotoelectrochemical
approach
for
silylation
cyclization
of
CF3-substituted
N
-arylacrylamides
with
organosilanes
under
transition-metal-free
and
oxidant-free
conditions
has
been
developed.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(42), P. 5502 - 5505
Published: Jan. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(16), P. 1913 - 1928
Published: April 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(22), P. 2963 - 2968
Published: June 24, 2023
Comprehensive
Summary
A
photoelectrochemical
approach
for
the
C—H
silylation
of
heteroarenes
through
dehydrogenation
cross‐coupling
with
H
2
evolution
has
been
developed.
The
depends
on
hydrogen
atom
transfer
(HAT)
from
silanes
to
Cl‐radical
generated
light‐induced
homolytic
cleavage
Cl
,
in
which
was
produced
by
electrochemical
oxidation
chloride.
large
number
silylated
heterocyclic
molecules
are
rapidly
constructed
satisfactory
yields
without
relying
oxidants
and
metal
reagents.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(40), P. 9597 - 9629
Published: Jan. 1, 2023
Polyesters
based
on
polyols
have
emerged
as
promising
biomaterials
for
various
biomedical
applications,
such
tissue
engineering
and
drug
delivery
systems,
due
to
their
biocompatibility,
biodegradability,
versatile
physicochemical
properties.
