Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(2)
Published: Jan. 27, 2023
Abstract
As
an
emerging
opportunity
to
expand
the
reactivity
repertoire
of
enzymes
achieve
unnatural
transformations
in
organic
synthesis,
enzyme
promiscuity
has
attracted
great
interest
recent
years.
The
combination
catalysis
and
photo‐/electro‐redox
which
can
benefit
from
both
exquisite
selectivity
unique
chemical
accessible
photo‐/electro‐chemistry
many
advantages,
such
as
new
reactivity,
high
enantioselectivity,
green
yields.
In
past
decades,
most
photoenzymatic
enzymatic
electrosynthesis
mainly
focused
on
exploiting
regenerated
cofactors
function
native
activity.
However,
developments
have
demonstrated
that
combining
unlock
asymmetric
reactions.
This
minireview
highlights
these
strategies
covers
literature
2016
date.
Furthermore,
future
development
direction
this
field
is
prospected.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1792 - 1796
Published: Feb. 28, 2024
A
mild
and
effective
strategy
for
the
asymmetric
synthesis
of
C2-quaternary
indolin-3-ones
from
2-alkynyl
arylazides
ketones
by
gold/chiral
amine
relay
catalysis
is
described.
In
this
reaction,
undergo
gold-catalyzed
cyclization,
nucleophilic
attack,
oxidation
to
form
intermediate
2-phenyl-3H-indol-3-ones,
followed
an
l-proline-catalyzed
Mannich
reaction
with
ketones,
afford
corresponding
products
in
satisfactory
yields
excellent
enantio-
diastereoselectivities.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(17), P. 6853 - 6858
Published: Jan. 1, 2023
we
developed
an
environmentally
friendly
strategy
that
combines
in
situ
generation
of
a
diazo
reagent
with
biocatalysis
for
the
asymmetric
cyclopropanation
olefins.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(3), P. 1625 - 1634
Published: Jan. 25, 2023
In
this
article,
an
electrochemical
method
for
the
direct
synthesis
of
β-amino
alcohols
from
imines
and
ketones
is
described.
Mechanistic
studies,
including
a
radical
trapping
experiment,
electron
paramagnetic
resonance,
cyclic
voltammetry,
divided-cell
electrolysis
support
radical-involved
reductive
cross
coupling
with
at
cathode.
The
use
abundant
easily
prepared
starting
materials,
high
atom-
step-economy,
insensitivity
to
air
moisture
make
synthetic
strategy
more
efficient
construction
various
alcohol
derivatives.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(25)
Published: April 24, 2024
Abstract
The
efficient
synthesis
of
chiral
2,2‐disubstituted
indolin‐3‐ones
is
great
importance
due
to
its
significant
synthetic
and
biological
applications.
However,
catalytic
enantioselective
methods
for
de
novo
such
heterocycles
remain
scarce.
Herein,
a
novel
cyclizative
rearrangement
readily
available
anilines
vicinal
diketones
the
one‐step
construction
enantioenriched
presented.
reaction
proceeds
through
self‐sorted
[3+2]
heteroannulation/regioselective
dehydration/1,2‐ester
shift
process.
Only
phosphoric
acid
employed
promote
entire
sequence
simplify
manipulation
this
protocol.
Various
common
aniline
derivatives
are
successfully
applied
asymmetric
as
1,3‐binuclephiles
first
time.
Remarkably,
observed
stereoselectivity
proposed
originate
from
an
amine‐directed
regio‐
ortho
‐Csp
2
‐H
addition
ketones.
A
range
transformations
resulting
products
demonstrated
well.
2,2-Disubstituted
indolin-3-ones,
which
are
essential
components
in
many
manufactured
chemicals,
dyes,
and
naturally
occurring
bioactive
alkaloids,
have
emerged
as
exciting
synthetic
targets.
Much
attention
has
been
paid
to
accessing
these
units,
particularly
an
asymmetric
fashion,
during
the
last
decade.
In
this
review
article,
we
discuss
current
state
of
available
methods
with
existing
mechanistic
pathways
for
chiral
indolin-3-one
derivatives
under
various
catalytic
systems.
This
overall
presentation
protocols
access
2,2-disubstituted
or
fused
indolin-3-ones
aza-quaternary
centre
is
categorized
based
on
reaction
modes
2-substituted-3H-indole-3-one
other
similar
protocols.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Direct
benzylic
C-H
carboxylation
stands
as
a
high
atom
economy,
efficient,
and
convenient
route
for
the
synthesis
of
valuable
carboxylic
acids,
which
are
great
significance
in
many
pharmaceuticals
bioactive
molecules.
However,
inherent
inertness
both
bonds
carbon
dioxide
presents
challenge
further
transformations.
Herein,
we
report
our
efforts
to
overcome
this
obstacle
via
halide-promoted
linear
paired
electrolysis
generate
various
acids.
Remarkably,
process
is
transition-metal-
base-free,
making
it
environmentally
benign
cost-effective.
Besides,
suitable
constructing
wide
range
primary,
secondary,
tertiary
acids
under
mild
reaction
conditions,
demonstrating
broad
substrate
scopes
good
functional
group
tolerance.
Furthermore,
protocol
enables
direct
some
drug
molecules,
including
Flurbiprofen,
Ibuprofen,
Naproxen,
facilitates
late-stage
modification
complex
compounds,
showcasing
practical
application
synthetic
chemistry
underscores
its
potential
advance
related
compounds.
