Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences DOI

Jingqi Li,

Xinda Cai,

Peng Jiang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Sept. 19, 2023

Nanozymes, next-generation enzyme-mimicking nanomaterials, have entered an era of rational design; among them, Co-based nanozymes emerged as captivating players over times. been developed and garnered significant attention the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, multifunctionality stemming from magnetic photothermal conversion effects, cavitation relaxation efficiency, made a rising star. This review presents first comprehensive profiling in chemistry, biology, environmental sciences. The begins by scrutinizing various synthetic methods employed for nanozyme fabrication, such template sol-gel methods, highlighting their distinctive merits chemical standpoint. Furthermore, detailed exploration wide-ranging applications biosensing biomedical therapeutics, well contributions to monitoring remediation is provided. Notably, drawing inspiration state-of-the-art techniques omics, analysis undertaken, employing analogous statistical methodologies provide valuable guidance. To conclude, outlook on challenges prospects presented, spanning microscopic physicochemical mechanisms macroscopic clinical translational applications.

Language: Английский

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications DOI
Chao Peng,

Ruoyu Pang,

Jing Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

Citations

160
A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis DOI
Longwei Wang, Xiaodi Zhang, Zhen You

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

Citations

115
Atomically Site Synergistic Effects of Dual-Atom Nanozyme Enhances Peroxidase-like Properties DOI

Ruijin Zeng,

Yanli Li,

Xuehan Hu

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(13), P. 6073 - 6080

Published: June 26, 2023

Pursuing effective and generalized strategies for modulating the electronic structures of atomically dispersed nanozymes with remarkable catalytic performance is exceptionally attractive yet challenging. Herein, we developed a facile "formamide condensation carbonization" strategy to fabricate library single-atom (M1-NC; 6 types) dual-atom (M1/M2-NC; 13 metal-nitrogen-carbon (M = Fe, Co, Ni, Mn, Ru, Cu) reveal peroxidase- (POD-) like activities. The Fe1Co1-NC nanozyme Fe1-N4/Co1-N4 coordination displayed highest POD-like activity. Density functional theory (DFT) calculations revealed that Co atom site synergistically affects d-band center position Fe served as second reaction center, which contributes better Finally, Fe1Co1 NC was shown be in inhibiting tumor growth both vitro vivo, suggesting diatomic synergy an developing artificial novel nanocatalytic therapeutics.

Language: Английский

Citations

110
Biomedicine meets nanozyme catalytic chemistry DOI

Changyu Cao,

Nan Yang,

Xiaorui Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

Citations

92
Recent advances in the development and analytical applications of oxidase-like nanozymes DOI
Min Feng, Xue Li, Xiaodan Zhang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 166, P. 117220 - 117220

Published: Aug. 3, 2023

Language: Английский

Citations

90
An S-scheme CeO2/ foveolate g-C3N4 composite with horseradish peroxidase activity for photo-enzyme synergistic catalytic degradation of phenanthrene DOI
Chujun Feng, Jian Rong, Yuzhe Zhang

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2023, Volume and Issue: 337, P. 123005 - 123005

Published: June 16, 2023

Language: Английский

Citations

79
Spatial Position Regulation of Cu Single Atom Site Realizes Efficient Nanozyme Photocatalytic Bactericidal Activity DOI Open Access
Honghui Ou, Yuping Qian, Lintian Yuan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(46)

Published: July 27, 2023

Recently, single-atom nanozymes have made significant progress in the fields of sterilization and treatment, but their catalytic performance as substitutes for natural enzymes drugs is far from satisfactory. Here, a method reported to improve enzyme activity by adjusting spatial position site on nanoplatforms. Two types Cu are synthesized interlayer (CuL /PHI) in-plane (CuP poly (heptazine imide) (PHI) through different synthesis pathways. Experimental theoretical analysis indicates that PHI can effectively adjust coordination number, bond length, electronic structure single atoms compared position, thereby promoting photoinduced electron migration O2 activation, enabling effective generate reactive oxygen species (ROS). Under visible light irradiation, photocatalytic bactericidal CuL /PHI against aureus ≈100%, achieving same antibacterial effect antibiotics, after 10 min low-dose exposure 2 h incubation.

Language: Английский

Citations

74
A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment DOI Creative Commons
Hang Yao, Feifei Wang, Hui Chong

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 17, 2023

Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system these two problems has yet to be established. Here, chemotherapy drug curcumin (CCM) is decorated Prussian blue analogs a straightforward cost-saving manner. Modified CCM can released inflammatory tissue (acidic environment), eventually causing M1 transform into M2 inhibiting pro-inflammatory factors. Co(III) Fe(II) have abundant valence variations, lower REDOX potential CCM-CoFe PBA enables ROS clearance through multi-nanomase activity. In addition, effectively alleviated symptoms UC mice induced by DSS inhibited progression disease. Therefore, present material may used as new therapeutic agent for UC.

Language: Английский

Citations

60
Activity Regulating Strategies of Nanozymes for Biomedical Applications DOI
Xiaoteng Ding, Zhen Zhao, Yanfang Zhang

et al.

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Language: Английский

Citations

58
Self‐Assembled Copper‐Based Nanoparticles for Glutathione Activated and Enzymatic Cascade‐Enhanced Ferroptosis and Immunotherapy in Cancer Treatment DOI
Wenfang Song,

Jin‐Yue Zeng,

Ping Ji

et al.

Small, Journal Year: 2023, Volume and Issue: 19(35)

Published: April 28, 2023

As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) generation efficiency. Here, this work designs self-assembled copper-alanine nanoparticles (CACG) loaded with glucose oxidase (GOx) cinnamaldehyde (Cin) for situ activated enzymatic cascade-enhanced immunotherapy. In response to GSH-rich acidic TME, CACG allows effectively co-deliver Cu2+ , Cin, GOx into tumors. Released Cin consumes GSH through Michael addition, accompanying the reduction of Cu+ further depletion. With cascade -catalyzed Fenton reactions enzyme-catalyzed GOx, could get rid restriction insufficient hydrogen peroxide leading a robust constant ROS. high efficiency depletion ROS production, significantly enhanced vivo. Moreover, elevated oxidative stress triggers immune responses promoting dendritic cells maturation T cell infiltration. The vivo results prove that efficiently inhibit growth 4T1 tumor-bearing mouse model without causing obvious systemic toxicity, suggesting great potential enhancing immunotherapy effective treatment.

Language: Английский

Citations

55