Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

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Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

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Precise Tuning of the D-Band Center of Dual-Atomic Enzymes for Catalytic Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(14), P. 10023 - 10031

Published: March 30, 2024

Single-atom nanozyme-based catalytic therapy is of great interest in the field tumor therapy; however, their development suffers from low affinity nanozymes to substrates (H2O2 or O2), leading deficient activity microenvironment. Herein, we report a new strategy for precisely tuning d-band center dual-atomic sites enhance metal atomic and on class edge-rich N-doped porous carbon Fe–Mn (Fe1Mn1–NCe) greatly boosting multiple-enzyme-like activities. The as-made Fe1Mn1–NCe achieved much higher efficiency (Kcat/Km = 4.01 × 105 S–1·M–1) than Fe1–NCe 2.41 104 with an outstanding stability over 90% retention after 1 year, which best among reported dual-atom nanozymes. Theoretical calculations reveal that synergetic effect Mn upshifts Fe −1.113 −0.564 eV enhances adsorption capacity substrate, thus accelerating dissociation H2O2 weakening O–O bond O2. We further demonstrated superior enzyme-like combined photothermal could effectively inhibit growth vivo, inhibition rate up 95.74%, highest value artificial enzyme therapies so far.

Language: Английский

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Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Small, Journal Year: 2023, Volume and Issue: 20(14)

Published: Nov. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Language: Английский

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Hydrogen Sulfide Gas Amplified ROS Cascade: FeS@GOx Hybrid Nanozyme Designed for Boosting Tumor Chemodynamic Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: April 11, 2023

Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify cascade boosting chemodynamic immunotherapy. In FeS@GOx, GOx allows conversion endogenous glucose gluconic acid hydrogen peroxide, which provides favorable increasing peroxide subsequent Fenton reaction FeS nanozymes, thus reinforcing production. Notably, sulfide (H2 S) release activated generation-related pH decrease, can suppress activity thioredoxin reductase catalase further inhibit elimination. Thus, FeS@GOx sustainably accumulation perturb intracellular improve therapy trigger robust immunogenic cell death effective combined with checkpoint blockade. This work proposes feasible H2 S amplified strategy employing bioinspired nanozyme, providing novel pathway multi-enzyme-mediated TME modulation precise efficient

Language: Английский

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Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2298 - 2316

Published: Jan. 26, 2024

Bacterial infection hampers wound repair by impeding the healing process. Concurrently, inflammation at site triggers production of reactive oxygen species (ROS), causing oxidative stress and damage to proteins cells. This can lead chronic wounds, posing severe risks. Therefore, eliminating bacterial reducing ROS levels are crucial for effective healing. Nanozymes, possessing enzyme-like catalytic activity, convert endogenous substances into highly toxic substances, such as ROS, combat bacteria biofilms without inducing drug resistance. However, current nanozyme model with single enzyme activity falls short meeting complex requirements antimicrobial therapy. Thus, developing nanozymes multiple enzymatic activities is essential. Herein, we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles (Ru-PC NPs) diverse aid infections. Under acidic conditions, due their glutathione (GSH) depletion peroxidase (POD)-like Ru-PC NPs combined H2O2 exhibit excellent antibacterial effects. in neutral environment, NPs, catalase (CAT) decompose O2, alleviating hypoxia ensuring sufficient supply. Furthermore, possess exceptional antioxidant capacity through superior superoxide dismutase (SOD) effectively scavenging excess nitrogen (RNS) environment. maintains balance system prevents inflammation. also promote polarization macrophages from M1 M2, facilitating More importantly, show good biosafety negligible toxicity. In vivo models have confirmed efficacy inhibiting promoting The focus this work highlights quadruple its potential reduce bacteria-infected

Language: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Language: Английский

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Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Language: Английский

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Coordination Engineering in Fe‐Mn Dual‐Atom Nanozyme: Yielding ROS Storm to Efficiently Promote Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Multidrug‐resistant bacterial infections have become a global public health issue. To solve this dilemma, single‐atom nanozymes been used as versatile antibiotics. However, the efficacy of individual nanozyme is hindered by their limited catalytic activity and antibacterial effect. Herein, novel N 3 ‐Fe 1 ‐Mn ‐N 2 S (Fe/Mn‐SNC), with neighboring Mn Fe dual pairs decorated on yolk‐shell‐like carbon skeleton, constructed through partial modulation Fe‐Mn site coordination sulfur atoms. The developed Fe/Mn‐SNC possesses superior multienzyme‐like cascade activities (oxidase‐, superoxide‐, peroxidase‐like activities). It catalyzes conversion O into ·− its oxidase‐like activity, which then decomposed H superoxide‐like enzyme properties. Ultimately, ·OH generated under influence activity. This process effectively kills bacteria without addition , contributing to overcoming resistance issues. Density functional theory calculations indicate that direct coordinated atom enhances dual‐atomic provides an additional active for enhancement superoxidase‐ activities. Fe/Mn‐SNC, high effect biosafety, showing wide potential applications in medical technology consumer care. work opens new avenue designing multifunctional applications.

Language: Английский

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