Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.

Language: Английский

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Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 11, 2024

Drug delivery is a key component of nanomedicine, and conventional relies on the adsorption or encapsulation drug molecules to nanomaterial. Many vehicles contain metal ions, such as metal-organic frameworks, oxides, transition dichalcogenides, MXene, noble nanoparticles. These materials have high content pose potential long-term toxicity concerns leading difficulties for clinical approval. In this review, recent developments are summarized in use ligands coordination forming various nanomaterials soft materials. these cases, drug-to-metal ratio much higher than adsorption-based strategies. The divided into small-molecule drugs, nucleic acids, proteins. formed hybrid mainly include nanoparticles hydrogels, upon which targeting can be grafted improve efficacy further decrease toxicity. application addressing cancer, viral infection, bacterial infection inflammatory bowel disease, bone diseases reviewed. end, some future directions discussed from fundamental research, science, medicine.

Language: Английский

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Strategies for the Nuclear Delivery of Metal Complexes to Cancer Cells

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Jan. 4, 2024

Abstract The nucleus is an essential organelle for the function of cells. It holds most genetic material and plays a crucial role in regulation cell growth proliferation. Since many antitumoral therapies target nucleic acids to induce death, tumor‐specific nuclear drug delivery could potentiate therapeutic effects prevent potential off‐target side on healthy tissue. Due their great structural variety, good biocompatibility, unique physico‐chemical properties, organometallic complexes other metal‐based compounds have sparked interest as promising anticancer agents. In this review, strategies specific metal are summarized discussed highlight parameters consider design new candidates. Moreover, existing opportunities challenges tumor‐specific, nucleus‐targeting emphasized outline some perspectives help cancer treatments.

Language: Английский

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Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy

ChemBioChem, Journal Year: 2023, Volume and Issue: 24(16)

Published: March 14, 2023

Abstract Antimicrobial resistance (AMR) is a growing global problem with more than 1 million deaths due to AMR infection in 2019 alone. New and innovative therapeutics are required overcome this challenge. photodynamic therapy (aPDT) rapidly area of research poised provide much needed help the fight against AMR. aPDT works by administering photosensitizer (PS) that activated only when irradiated light, allowing high spatiotemporal control selectivity. The PS typically generates reactive oxygen species (ROS), which can damage variety key biological targets, potentially circumventing existing mechanisms. Metal complexes well known display excellent optoelectronic properties, recent focus has begun shift towards their application tackling microbial infections. Herein, we review last five years progress emerging field small‐molecule metal complex PSs for aPDT.

Language: Английский

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The use of fluorene in the photorelease of nitric oxide from Ru(terpyridine)(NO) complexes by one- or two-photon absorption

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216417 - 216417

Published: Jan. 9, 2025

Language: Английский

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Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 5561 - 5561

Published: April 29, 2023

The introduction of biologically relevant organic moieties in the coordination sphere transition metal complexes has recently become a well-established strategy to increase selectivity and biocompatibility metallodrugs. In this review, major advances achieved area research last three years are described detail. Particular attention is given bearing main biomolecules life: carbohydrates, lipids, nucleotides, proteins vitamins. Each paragraph summarizes synthetic employed obtain interest as well most interesting biological results obtained with these potential Moreover, structure–activity relationships observed by different groups discussed, goal suggesting reader ligand/metal centre combinations that provide promising fight against cancer. Some compounds examined review other bioconjugated published recent decades exhibit towards cancer cells over normal ones specific mode action. These latter aspects basis what commonly known anticancer target therapy.

Language: Английский

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Bioresponsive fluorescent probes active in the second near‐infrared window

iRadiology, Journal Year: 2023, Volume and Issue: 1(1), P. 36 - 60

Published: March 1, 2023

Abstract Emerging stimuli‐responsive composite probes active in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold vast potential for improving vivo imaging performance with minimized noise interference. The interactions among external irradiation, shell species, and emissive core are key factors design of smart structures. irradiation provides energy species to generate intense NIR‐II fluorescence signals, while transfer process hinders emission inner structure probes. However, if pathophysiological stimuli interrupt above processes, then signals recovered. This review covers based on diverse fluorescent responding various biological stimuli, including ONOO − , overexpressed reactive sulfur abnormally expressed enzymes, abnormal levels physiological metabolites. Finally, appreciate these advances, challenges perspectives highlighted.

Language: Английский

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An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo‐Sensitizer Evokes Mutually Reinforcing "Closed‐Loop" Ferroptosis and Immunotherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 10, 2024

The hypoxic microenvironment of solid tumors severely lowers the efficacy oxygen-dependent photodynamic therapy (PDT). development hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop "closed-loop" based on PDT-induced ferroptosis and immune reported. Due its electron donor-acceptor (D-A) structure, Re-TTPY undergoes energy transfer processes under 550 nm light irradiation displays type I/II combined capability, which can generate

Language: Английский

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Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(12), P. 8547 - 8556

Published: March 18, 2024

Photocatalysis has found increasing applications in biological systems, for example, localized prodrug activation; however, high-energy light is usually required without giving sufficient efficiency and target selectivity. In this work, we report that ion pairing between photocatalysts prodrugs can significantly improve the photoactivation enable tumor-targeted activation by red light. This exemplified a gold-based (1d) functionalized with morpholine moiety. Such modification causes 1d to hydrolyze aqueous solution, forming cationic species tightly interacts anionic photosensitizers including Eosin Y (EY) Rose Bengal (RB), along significant bathochromic shift of absorption tailing far-red region. As result, high EY or RB under low-energy was found, leading an effective release active gold living cells, as monitored gold-specific biosensor (GolS-mCherry). Importantly, moiety, pKa ∼6.9, brings highly pH-sensitive preferential ionic interaction slightly acidic condition over normal physiological pH, enabling irradiation vitro vivo. Since similar change other morpholine/amine-containing clinic drugs, photocages, precursors reactive labeling intermediates, it believed ion-pairing strategy could be extended targeted different mapping microenvironment

Language: Английский

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Photodynamic Therapy with Targeted Release of Boron-Dipyrromethene Dye from Cobalt(III) Prodrugs in Red Light

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(15), P. 6822 - 6835

Published: April 1, 2024

Boron-dipyrromethene (BODIPY) dyes are promising photosensitizers for cellular imaging and photodynamic therapy (PDT) owing to their excellent photophysical properties the synthetically tunable core. Metalation provides a convenient way overcome drawbacks arising from low aqueous solubility. New photo-/redox-responsive Co(III) prodrug chaperones developed as anticancer PDT agents efficient delivery of red-light-active BODIPY dyes. The photobiological activity heteroleptic complexes derived tris(2-pyridylmethyl)amine (TPA) acetylacetone-conjugated PEGylated distyryl (HL1) or its dibromo analogue (HL2), [CoIII(TPA)(L1/L2)](ClO4)2 (1 2), investigated. Co(III)/Co(II) redox potential is tuned using Co(III)-TPA scaffold. Complex 1 displays in vitro release on red light irradiation. 2, having good singlet oxygen quantum yield (ΦΔ ∼ 0.28 DMSO), demonstrates submicromolar photocytotoxicity HeLa cancer cells (IC50 ≈ 0.23 μM) while being less toxic HPL1D normal light. Cellular emissive complex shows mitochondrial localization significant penetration into tumor spheroids. 2 supercoiled DNA photocleavage apoptotic cell death through phototriggered generation reactive species. Co(III)–BODIPY conjugates exemplify new type phototherapeutic with better efficacy than organic alone window.

Language: Английский

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