Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3807 - 3839

Published: Jan. 1, 2024

This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.

Language: Английский

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Synthesis and Characterization of a New Neodymium Complex: DFT Insights and Potential Anticancer Applications

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 18, 2025

ABSTRACT A new complex of type [Nd (HL) (NO 3 ) 2 ] has been synthesized with a Schiff base ligand H L derived from 2‐hydroxy‐3‐methoxybenzaldehyde and L‐histidine. The structure the was established using elemental analysis, molar conductivities, FT‐IR, 1 HNMR, SEM, x‐ray diffraction (XRD) spectroscopy. FT‐IR data revealed that acts as tetradentate through carboxylic acid, azomethine nitrogen, methoxy oxygen, hydroxyl groups. Based on electronic spectra, an octahedral configuration hypothesized for complex. TGA method employed to study thermal behavior its complex, thermodynamic parameters were determined Coats–Redfern equations. XRD analysis compounds possess nanoscale dimensions, their crystallinity significantly enhanced by coordination Nd(III) ion L. DFT calculations performed optimize geometry proposed structures, indicating improved stabilities. reduced HOMO–LUMO gap in further highlights remarkable conductive properties. surface morphology analyzed SEM investigate structural characteristics. images reveal variety particle shapes, including elongated, prismatic, irregular blocky particles sharp edges, suggesting crystalline nature. evaluated anticancer activity against prostate carcinoma, breast lung carcinoma cell lines. inhibition rate 92.81%, 93.25%, 94.58%, respectively. results demonstrated exhibited compared alone, likely due These findings suggest holds promise potent agent.

Language: Английский

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Cisplatin Resistance in Cancer Therapy: Causes and Overcoming Strategies

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(25)

Published: June 26, 2024

Abstract Dr. S. Shruthi, Prof. K. Bhasker Shenoy. Cisplatin (CDDP) is the first metal‐based drug and has been a popular in treatment of various types cancer for decades. Cancer cell death promoted by this platinum‐based generating DNA adducts activating apoptotic signaling pathways. The development resistance foremost clinical concern that compromises its efficacy. mechanism CDDP encompasses changes influx efflux, accumulation reduction, enhanced detoxification, repair which may affect therapeutic value. Researchers have paid significant attention to overcoming resistance, provides an opportunity enhance outcomes. Combinational therapy, use analogs, phytochemicals, nanoparticle‐mediated delivery, gene targeting regulation induced epigenetic are specific regimens overcome burden. In review, we summarize mechanisms involved strategies considered these hurdles concerning preclinical studies. This provide insights into further novel approaches uproot ascertain safer more effective therapy.

Language: Английский

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Dinuclear NHC–gold(i)–thiolato and –alkynyl complexes: synthesis, anticancer activity, and catalytic activity in lactonization reactions

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(18), P. 7939 - 7945

Published: Jan. 1, 2024

A series of novel dinuclear NHC–gold–thiolato and –alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient simple synthetic route.

Language: Английский

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Antibody Drug Conjugates for Cancer Therapy: From Metallodrugs to Nature-Inspired Payloads

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8651 - 8651

Published: Aug. 8, 2024

This review highlights significant advancements in antibody–drug conjugates (ADCs) equipped with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods such us maleimide succinimide conjugation classical condensation reactions are prevalent metallodrugs natural compounds. However, emerging non-conventional as photoconjugation gaining traction due to their milder conditions and, an aspect which minimizes side reactions, selective formation of ADC. The also summarizes the therapeutic diagnostic properties these ADCs, highlighting enhanced selectivity reduced effects cancer treatment compared non-conjugated payloads. ADCs combine specificity monoclonal antibodies cytotoxicity chemotherapy drugs, offering a targeted approach elimination cells while sparing healthy tissues. mechanism has demonstrated impressive clinical efficacy various malignancies. Key future include improved linker technology stability controlled release cytotoxic agents, incorporation novel, more potent, identification new cancer-specific antigens through genomic proteomic technologies. expected play crucial role combination therapies immune checkpoint inhibitors, CAR-T cells, small molecule leading durable potentially curative outcomes. Ongoing research trials expanding capabilities, paving way effective, safer, personalized treatments, positioning cornerstone modern medicine hope patients.

Language: Английский

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Metal-Based Drug–DNA Interactions and Analytical Determination Methods

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4361 - 4361

Published: Sept. 13, 2024

DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, bind along the sites of nucleic acid with aim changing its structure, genetic message, and, implicitly, functions. Currently, there are several mechanisms known to be involved in binding. These covalent non-covalent interactions. The interaction or metal base coordination is an irreversible binding it represented by intra-/interstrand cross-link. generally a reversible intercalation between pairs, insertion, major and/or minor groove binding, electrostatic interactions sugar phosphate backbone. In present review, we focus on types DNA-metal complex (including some representative examples) presenting methods currently used study them.

Language: Английский

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Evaluation of oxadiazole-diamine platinum(II) and palladium(II) complexes: synthesis, solvent stability and biological profiling

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: April 29, 2025

Language: Английский

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Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes

RSC Advances, Journal Year: 2025, Volume and Issue: 15(18), P. 14058 - 14071

Published: Jan. 1, 2025

In this study, we report the synthesis and characterization of novel organopalladium complexes featuring 1,3,5-triaza-7-phosphaadamantane (PTA)-based ligands, including several cationic derivatives prepared as hexafluorophosphate salts to prevent halide exchange reactions. The incorporate diverse fragments-Pd(ii)-vinyl, Pd(ii)-butadienyl, Pd(ii)-allyl, Pd(ii)-imidoyl, Pd(ii)-aryl, Pd(0)-alkene-many which have recently shown promising antitumor activity. Most reactions proceeded rapidly at room temperature under aerobic conditions using non-anhydrous solvents. Biological evaluation against ovarian cancer (A2780), cisplatin-resistant (A2780cis), triple-negative breast (MDA-MB-231), glioblastoma (U87), non-cancerous fibroblasts (MRC-5) revealed remarkable cytotoxicity complexes, particularly those with Pd(0)-alkene fragments. These compounds demonstrated activity comparable or exceeding cisplatin, some showing up two orders magnitude greater efficacy. Importantly, were highly selective for cells, exhibiting minimal toxicity toward MRC-5 fibroblasts, unlike cisplatin. Complex 14b, that contains a fragment MePTA+ was only one exhibited excellent across all cell lines, glioblastoma. findings underscore potential PTA-based anticancer agents, warranting further in vitro vivo studies, well mechanistic investigations.

Language: Английский

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Ru(ii)/Os(ii)-based carbonic anhydrase inhibitors as photodynamic therapy photosensitizers for the treatment of hypoxic tumours

Chemical Science, Journal Year: 2023, Volume and Issue: 14(42), P. 11749 - 11760

Published: Jan. 1, 2023

Photodynamic therapy (PDT) is a medical technique for the treatment of cancer. It based on use non-toxic molecules, called photosensitizers (PSs), that become toxic when irradiated with light and produce reactive oxygen specious (ROS) such as singlet (1O2). This light-induced toxicity rather selective since physician only targets specific area body, leading to minimal side effects. Yet, strategy improve further selectivity this confine delivery PS cancer cells instead spreading it randomly throughout body prior irradiation. To address problem, we present here novel sulfonamide-based monopodal dipodal ruthenium osmium polypyridyl complexes capable targeting carbonic anhydrases (CAs) are major target in therapy. CAs overexpressed membrane or cytoplasm various cells. We therefore anticipated accumulation our outside cell irradiation would PDT treatment. show have high affinity CAs, accumulate overexpressing CA importantly kill under both normoxic hypoxic conditions upon at 540 nm. More importantly, Os(ii) compounds still exhibit some phototoxicity 740 nm conditions. knowledge, first description ruthenium/osmium-based PSs inhibitors cancers.

Language: Английский

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Liposomal Formulations of Metallodrugs for Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9337 - 9337

Published: Aug. 28, 2024

The search for new antineoplastic agents is imperative, as cancer remains one of the most preeminent causes death worldwide. Since discovery therapeutic potential cisplatin, study metallodrugs in chemotherapy acquired increasing interest. Starting from cisplatin derivatives, such oxaliplatin and carboplatin, last years, different compounds were explored, employing metal centers iron, ruthenium, gold, palladium. Nonetheless, face several drawbacks, low water solubility, rapid clearance, possible side toxicity. Encapsulation has emerged a promising strategy to overcome these issues, providing both improved biocompatibility protection payload degradation biological environment. In this respect, liposomes, which are spherical vesicles characterized by an aqueous core surrounded lipid bilayers, have proven be ideal candidates due their versatility. fact, they can encapsulate hydrophilic hydrophobic drugs, biocompatible, properties tuned improve selective delivery tumour sites exploiting passive active targeting. review, we report recent findings on liposomal formulations metallodrugs, with focus encapsulation techniques obtained results.

Language: Английский

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