Science Advances, Journal Year: 2023, Volume and Issue: 9(44)
Published: Nov. 1, 2023
Thermoelectric therapy has emerged as a promising treatment strategy for oncology, but it is still limited by the low thermoelectric catalytic efficiency at human body temperature and inevitable tumor thermotolerance. We present photothermoelectric (PTET) based on triphenylphosphine-functionalized Cu
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)
Published: Feb. 21, 2024
Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction may develop primary or acquired resistance. Further, multidrug combination used to prevent this in clinic places significant burden on patients. To address issue, work develops nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) exceptional near-infrared (NIR) absorption capability, small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This realizes targeted delivery multiple therapeutic effects, including chemo-and photothermal activities, oxidative stress, immune response. In vitro assays reveal HCT-modified nanoparticles exhibit specific recognition ability effective internalization by cells. The released PYR inhibit cell proliferation downregulating HER2 its associated pathways. NIR laser application induces effect tumor apoptosis, whereas an intracellular reactive oxygen species burst amplifies stress triggers cancer ferroptosis. Importantly, multimodal therapy also promotes upregulation genes related TNF NF-κB signaling pathways, enhancing activation immunogenic death. vivo studies confirm reduction volume after treatment, substantiating potential effectiveness these nanocarriers.
Language: Английский
Citations
16
Small Structures, Journal Year: 2024, Volume and Issue: 5(6)
Published: March 25, 2024
Traditional antibacterial agents are often observed to be ineffective because bacteria evolved strains with greater antibiotic resistance. Here, vigorous chitosan‐stabilized PtAu nanoparticles (CSPA) multienzyme‐like activity successfully fabricated, which serve an effective artificial nanozyme enhance for mixed bacterial infection wound treatment. Ultrasmall size CSPA exhibits excellent hydrophilicity and biocompatibility, possesses strong oxidase‐ peroxidase‐like generating a substantial amount of ROS (, 1 O 2 , ·OH) cause oxidative damage bacteria, also demonstrates nicotinamide adenine dinucleotide dehydrogenase‐like disrupting the respiratory chains, subsequently impedes adenosine triphosphate production. favorable broad‐spectrum at very low concentrations, prevents resistance, completely inhibits biofilm formation. Antibacterial Mechanism by transcriptomics is further revealed that can induce stress, hinder energy metabolism, disrupt synthesis function cell walls membranes. In vivo, population site promotes healing in rats. This study introduces novel approach, providing important insight into mechanism nanozymes promoting advancement nanocatalytic materials biomedical applications.
Language: Английский
Citations
16
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 6, 2024
Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence exacerbation metabolic diseases, nanozyme offer unique perspective therapy through multifunctional achieving essential results treatment diseases directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at cellular level, therapies several typical underlying are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, others. Finally, pharmacokinetics, safety analysis, challenges, outlooks application also presented. This review will provide some instructive perspectives promote development strategies disease therapy. Graphical
Language: Английский
Citations
16
Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
2
Science Advances, Journal Year: 2023, Volume and Issue: 9(44)
Published: Nov. 1, 2023
Thermoelectric therapy has emerged as a promising treatment strategy for oncology, but it is still limited by the low thermoelectric catalytic efficiency at human body temperature and inevitable tumor thermotolerance. We present photothermoelectric (PTET) based on triphenylphosphine-functionalized Cu
Language: Английский
Citations
41