Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(51)
Published: Sept. 5, 2024
Benzo[1,3,2]dithiazole-1,1,3-trioxides
are
bench-stable
and
easy-to-use
reagents.
In
photoredox
catalysis,
they
generate
methyl
perdeuteromethyl
radicals
which
can
add
to
a
variety
of
radical
acceptors,
including
olefins,
acrylamides,
quinoxalinones,
isocyanides,
enol
silanes,
N-Ts
acrylamide.
As
byproduct,
salt
is
formed
be
regenerated
the
original
methylating
agent.
Flow
chemistry
provides
an
option
for
reaction
scale-up
further
underscoring
synthetic
usefulness
these
methylation
Mechanistic
investigations
suggest
single-electron
transfer
(SET)
pathway
induced
by
catalysis.
Energy & Environmental Science,
Journal Year:
2023,
Volume and Issue:
16(4), P. 1590 - 1596
Published: Jan. 1, 2023
Herein,
we
demonstrate
cobaloximes
as
a
bioinspired
molecular
platform
for
exclusive
ammonia
synthesis
via
electrocatalytic
NO
2
−
reduction
(eNO
RR),
which
attained
98.5%
faradaic
efficiency
(FE)
under
close-to-neutral
conditions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(44), P. 8016 - 8021
Published: Oct. 30, 2023
Direct,
economical,
and
green
synthesis
of
deuterated
α-amino
phosphine
oxides
remains
an
elusive
challenge
in
synthetic
chemistry.
Herein,
we
report
a
visible-light-driven
umpolung
strategy
for
synthesizing
from
isocyanide
using
1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene
as
the
photocatalyst
D2O
deuterium
source.
Moreover,
streamlined
sustainable
methodology
can
be
applied
modification
amino
acids,
natural
products,
drugs.
The
strong
antiproliferative
activity
desired
products
indicates
that
method
could
provide
novel
privileged
scaffold
antitumor
drug
development.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(12), P. 7907 - 7975
Published: May 29, 2024
The
increasing
importance
of
azaheterocyclic
phosphonates
in
the
agrochemical,
synthetic,
and
medicinal
field
has
provoked
an
intense
search
development
synthetic
routes
for
obtaining
novel
members
this
family
compounds.
This
updated
review
covers
methodologies
established
since
2004,
focusing
on
synthesis
phosphonates,
which
phosphonate
moiety
is
directly
substituted
onto
to
structure.
Emphasizing
recent
advances,
classifies
newly
developed
approaches
according
ring
size
providing
information
biological
activities
whenever
available.
Furthermore,
summarizes
various
methods
formation
C–P
bonds,
examining
sustainable
such
as
Michaelis–Arbuzov
reaction,
Michaelis–Becker
Pudovik
Hirao
coupling,
Kabachnik–Fields
reaction.
After
analyzing
applications
investigated
years,
a
predominant
focus
evaluation
these
compounds
anticancer
agents
evident.
emerging
underline
versatility
potential
compounds,
highlighting
need
continued
research
expand
interesting
family.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(33)
Published: May 22, 2024
Abstract
Drawing
inspiration
from
nature
has
long
been
a
cornerstone
of
chemical
innovation,
with
natural
systems
offering
wealth
untapped
potential
for
discovery.
In
this
minireview,
we
delve
into
the
burgeoning
field
cobaloxime
catalysis
in
organic
synthesis,
which
mimics
catalytic
activity
organometallic
alkylcobalamine
enzymes.
Our
focus
lies
on
elucidating
latest
advancements
area,
as
well
delineating
primary
mechanistic
pathways
at
play.
By
describing,
and
comparing
these
mechanisms,
provide
comprehensive
overview
current
state‐of‐the‐art,
while
also
shedding
light
key
unresolved
challenges
that
await
further
exploration.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(42)
Published: Aug. 29, 2023
The
involvement
of
manganese
radical
for
halogen
atom
transfer
(XAT)
reactions
has
been
esteemed
as
one
reliable
method
but
encountered
with
limited
catalytic
models.
In
this
paper,
a
novel
bimetallic
relay
catalysis
Mn2
(CO)10
and
cobaloxime
developed
divergent
dehydrogenative
difluoroalkylation
alkenes
using
commercially
available
difluoroalkyl
bromides.
A
wide
range
structurally
diverse
terminal,
cyclic
internal
well
tetrasubstituted
are
found
to
be
good
coupling
partners
deliver
difluoroalkylated
allylic
products
difluoromethylated
products,
accompanied
the
production
H2
by-product.
This
strategy
features
broad
substrate
scope,
mild
reaction
conditions
excellent
functional
group
compatibility.
Its
success
represents
an
important
step-forward
expedite
construction
rich
library
products.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(10), P. 1722 - 1726
Published: March 4, 2023
Direct
N-allylation
of
azoles
with
hydrogen
evolution
has
been
achieved
through
the
synergistic
combination
organic
photocatalysis
and
cobalt
catalysis.
The
protocol
bypasses
stoichiometric
oxidants
prefunctionalization
alkenes
produces
(H2)
as
byproduct.
This
transformation
highlights
high
step-
atom-economy,
efficiency,
broad
functional
group
tolerance
for
further
derivatization,
which
opens
a
door
C-N
bond
formation
that
is
valuable
in
heterocyclic
chemistry.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 2996 - 3009
Published: Feb. 15, 2024
An
efficient
and
highly
regioselective
C6-phosphorylation
protocol
for
pyrrolo[2,3-d]pyrimidine
(7-DAP)
derivatives
with
various
H-phosphine
oxides
induced
by
visible
light
at
room
temperature
is
described
the
first
time.
This
has
been
successfully
achieved
combination
of
Na2-eosin
Y
as
a
photocatalyst
LPO
an
oxidant
under
transition
metal-
additive-free
conditions.
The
broad
substrate
scope,
good
functional
group
tolerance,
excellent
regioselectivity,
air
tolerant
conditions
make
this
process
favorable
modification
scaffold
enrich
phosphorylated
7-DAP
compounds
further
biological
evaluation.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(13), P. 8360 - 8368
Published: June 1, 2023
A
1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene
(4-CzIPN)-photocatalyzed
cascade
arylation/cyclization
reaction
of
2-isocyanobiaryls
and
iodonium
ylides
was
established
for
the
synthesis
6-arylated
phenanthridines.
This
is
first
example
employing
as
aryl
radical
sources
in
a
visible-light-induced
cyclization
reaction.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(18), P. 2556 - 2559
Published: Jan. 1, 2024
3-(2-Isocyanophenyl)quinazolin-4(3
H
)-ones
were
designed
and
synthesized
as
new
building
units
for
the
construction
of
novel
quinoxalino[2,1-
b
]quinazolinones
under
mild,
photocatalytic
metal-free
conditions.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(35), P. 4687 - 4690
Published: Jan. 1, 2024
A
visible-light-induced
carbophosphorylation/cyclization
of
N
-homoallyl
and
-allyl
aldehyde
hydrazones
with
phosphine
oxides
was
developed
to
obtain
phosphorylated
tetrahydropyridazines
dihydropyrazoles.
