Diastereomer Resolution of M₄L₆ Coordination Cages by Ultra‐High‐Resolution Ion‐Mobility Mass Spectrometry

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(27)

Published: April 26, 2023

Coordination cages can be used for enantio- and regioselective catalysis the selective sensing separation of isomeric guest molecules. Here, stereoisomers a family coordination are resolved using ultra-high-resolution cyclic ion-mobility mass spectrometry (cIM-MS). The observed ratio diastereomers is dependent on both metal ion counter ion. Moreover, point groups assigned through complementary NMR experiments. This method enables identification interrogation individual isomers in complex mixtures which cannot performed solution. Furthermore, these techniques allow stability within mixture to probed, with T-symmetric this case shown more robust than C3 S4 analogues.

Language: Английский

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Diastereomer Resolution of M₄L₆ Coordination Cages by Ultra‐High‐Resolution Ion‐Mobility Mass Spectrometry

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 135(27)

Published: April 26, 2023

Abstract Coordination cages can be used for enantio‐ and regioselective catalysis the selective sensing separation of isomeric guest molecules. Here, stereoisomers a family coordination are resolved using ultra‐high‐resolution cyclic ion‐mobility mass spectrometry (cIM‐MS). The observed ratio diastereomers is dependent on both metal ion counter ion. Moreover, point groups assigned through complementary NMR experiments. This method enables identification interrogation individual isomers in complex mixtures which cannot performed solution. Furthermore, these techniques allow stability within mixture to probed, with T ‐symmetric this case shown more robust than C 3 S 4 analogues.

Language: Английский

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Exploring the Gas‐Phase Formation and Chemical Reactivity of Highly Reduced M₈L₆ Coordination Cages

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(45)

Published: Sept. 14, 2022

Coordination cages with well-defined cavities show great promise in the field of catalysis on account their unique combination molecular confinement effects and transition-metal redox chemistry. Here, three coordination are reduced from native 16+ oxidation state to 2+ gas phase without observable structural degradation. Using this method, reaction rate constants for each reduction step were determined, no noticeable differences arising following either incorporation a C60 -fullerene guest or alteration cage chemical structure. The reactivity highly species toward oxygen is "switched-on" after threshold number steps, which influenced by molecules structure components. These new experimental approaches provide window explore chemistry highly-reduced that can be modulated altering structures encapsulated species.

Language: Английский

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Binding modes of high stoichiometry guest complexes with a Co₈L₁₂ cage uncovered by mass spectrometry

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(79), P. 11811 - 11814

Published: Jan. 1, 2023

We demonstrate how different modes of guest binding with a Co8L12 cubic cage can be determined using ESI-MS. High stoichiometry was observed, the guests preferentially externally, but internal inclusion also seen at higher loading.

Language: Английский

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