Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(22), P. 10878 - 10899
Published: Jan. 1, 2024
Autocatalysis,
a
self-sustained
replication
process
where
at
least
one
of
the
products
functions
as
catalyst,
plays
pivotal
role
in
life's
evolution,
from
genome
duplication
to
emergence
autocatalytic
subnetworks
cell
division
and
metabolism.
Leveraging
their
programmability,
controllability,
rich
functionalities,
DNA
molecules
have
become
cornerstone
for
engineering
circuits,
driving
diverse
technological
applications.
In
this
tutorial
review,
we
offer
comprehensive
survey
recent
advances
circuits
practical
implementations.
We
delve
into
fundamental
principles
underlying
construction
these
highlighting
reliance
on
DNAzyme
biocatalysis,
enzymatic
catalysis,
dynamic
hybridization
assembly.
The
discussed
circuitry
techniques
revolutionized
ultrasensitive
sensing
biologically
significant
molecules,
encompassing
genomic
DNAs,
RNAs,
viruses,
proteins.
Furthermore,
amplicons
produced
by
serve
building
blocks
higher-order
nanostructures,
facilitating
biomimetic
behaviors
such
high-performance
intracellular
bioimaging
precise
algorithmic
summarize
applications
extensively
address
current
challenges,
potential
solutions,
future
trajectories
circuits.
This
review
promises
novel
insights
advancement
utilization
across
bioanalysis,
biomedicine,
biomimetics.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8177 - 8177
Published: May 3, 2023
Due
to
the
specific
base-pairing
recognition,
clear
nanostructure,
programmable
sequence
and
responsiveness
of
DNA
molecule,
materials
have
attracted
extensive
attention
been
widely
used
in
controlled
release,
drug
delivery
tissue
engineering.
Generally,
strategies
for
preparing
are
based
on
assembly
multiple
strands.
The
construction
using
only
one
strand
can
not
save
time
cost,
but
also
avoid
defects
final
assemblies
generated
by
inaccuracy
ratios,
which
potentially
promote
large-scale
production
practical
application
materials.
In
order
use
form
assemblies,
sequences
be
palindromes
with
lengths
that
need
carefully.
this
review,
we
introduced
development
mainly
summarized
current
reported
formed
strand.
We
discussed
principle
Bioinorganic Chemistry and Applications,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 15
Published: Nov. 13, 2023
Numerous
supramolecular
platforms
inspired
by
natural
self-assembly
are
exploited
as
drug
delivery
systems.
The
spontaneous
arrangement
of
single
building
blocks
into
inorganic
and
organic
structures
is
determined
controlled
noncovalent
forces
such
electrostatic
interactions,
π-π
hydrogen
bonds,
van
der
Waals
interactions.
This
review
describes
the
main
characteristics
several
used
to
obtain
stable,
self-assembling
nanostructures
tailored
for
numerous
biological
applications.
Owing
their
versatility,
biocompatibility,
controllability,
these
find
application
in
diverse
fields
ranging
from
drug/gene
delivery,
theranostics,
tissue
engineering,
nanoelectronics.
Herein,
we
described
different
approaches
design
functionalize
nanomaterials
selective
a
specific
disease.
In
particular,
highlights
efficiency
applications
related
infectious
diseases
cancer.
Small,
Journal Year:
2023,
Volume and Issue:
20(20)
Published: Dec. 6, 2023
DNA
origami
synthesis
is
a
well-established
technique
with
wide-ranging
applications.
In
most
cases,
the
synthesized
must
be
purified
to
remove
excess
materials
such
as
oligos
and
other
functional
molecules.
While
several
purification
techniques
are
routinely
used,
all
have
limitations,
cannot
integrated
robotic
systems.
Here
use
of
solid-phase
reversible
immobilization
(SPRI)
beads
scalable,
high-throughput,
automatable
method
purify
demonstrated.
Not
only
can
this
unreacted
biomolecules
yields
comparable
existing
methods
while
maintaining
high
structural
integrity
origami,
but
it
also
into
an
automated
workflow
simultaneously
large
numbers
quantities
samples.
It
envisioned
that
SPRI
will
improve
scalability
nanostructures
both
for
research
commercial
BME Frontiers,
Journal Year:
2024,
Volume and Issue:
5
Published: Jan. 1, 2024
Recent
advancements
in
DNA
and
RNA
bioengineering
have
paved
the
way
for
developing
stimuli-responsive
nanostructures
with
remarkable
potential
across
various
applications.
These
nanostructures,
crafted
through
sophisticated
techniques,
can
dynamically
precisely
respond
to
both
physiological
physical
stimuli,
including
nucleic
acids
(DNA/RNA),
adenosine
triphosphate,
proteins,
ions,
small
molecules,
pH,
light,
temperature.
They
offer
high
sensitivity
specificity,
making
them
ideal
applications
such
as
biomarker
detection,
gene
therapy,
controlled
targeted
drug
delivery.
In
this
review,
we
summarize
methods
used
assemble
versatile
DNA/RNA
discuss
their
emerging
structural
biology
biomedicine,
biosensing,
delivery,
therapeutics.
Finally,
highlight
challenges
opportunities
rational
design
of
these
intelligent
bioengineered
nanostructures.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(22), P. 10878 - 10899
Published: Jan. 1, 2024
Autocatalysis,
a
self-sustained
replication
process
where
at
least
one
of
the
products
functions
as
catalyst,
plays
pivotal
role
in
life's
evolution,
from
genome
duplication
to
emergence
autocatalytic
subnetworks
cell
division
and
metabolism.
Leveraging
their
programmability,
controllability,
rich
functionalities,
DNA
molecules
have
become
cornerstone
for
engineering
circuits,
driving
diverse
technological
applications.
In
this
tutorial
review,
we
offer
comprehensive
survey
recent
advances
circuits
practical
implementations.
We
delve
into
fundamental
principles
underlying
construction
these
highlighting
reliance
on
DNAzyme
biocatalysis,
enzymatic
catalysis,
dynamic
hybridization
assembly.
The
discussed
circuitry
techniques
revolutionized
ultrasensitive
sensing
biologically
significant
molecules,
encompassing
genomic
DNAs,
RNAs,
viruses,
proteins.
Furthermore,
amplicons
produced
by
serve
building
blocks
higher-order
nanostructures,
facilitating
biomimetic
behaviors
such
high-performance
intracellular
bioimaging
precise
algorithmic
summarize
applications
extensively
address
current
challenges,
potential
solutions,
future
trajectories
circuits.
This
review
promises
novel
insights
advancement
utilization
across
bioanalysis,
biomedicine,
biomimetics.
