Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102327 - 102327
Published: June 4, 2024
Language: Английский
Materials, Journal Year: 2023, Volume and Issue: 16(15), P. 5363 - 5363
Published: July 30, 2023
The resistance of microorganisms to antimicrobial drugs is an important problem worldwide. To solve this problem, active searches for components, approaches and therapies are being carried out. Selenium nanoparticles have high potential activity. relevance their application indisputable, which can be noted due the significant increase in publications on topic over past decade. This review research aims provide reader with up-to-date information properties selenium nanoparticles, including susceptible microorganisms, mechanisms action bacteria effect nanoparticle describes most complete antiviral, antibacterial antifungal effects nanoparticles.
Language: Английский
Citations
56
Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)
Published: June 13, 2023
Nanozymes, featuring intrinsic biocatalytic effects and broad-spectrum antimicrobial properties, are emerging as a novel antibiotic class. However, prevailing bactericidal nanozymes face challenging dilemma between biofilm penetration bacterial capture capacity, significantly impeding their antibacterial efficacy. Here, this work introduces photomodulable nanozyme (ICG@hMnO
Language: Английский
Citations
53
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(35)
Published: May 17, 2023
Abstract Antibacterial elements and non‐contact heating abilities have been proven effective for antibacterial antibiofilm activities, but it remains a challenge to integrate both within one material. Herein, assisted by the high‐entropy effect, FeNiTiCrMnCu x alloy nanoparticles (HEA‐NPs) with excellent photothermal properties boosting performances are synthesized. Benefitting from synergetic effect of copper ions released thermal damage HEA‐NPs, more reactive oxygen species (ROS) generated, leading rupture cell membranes eradication biofilms. As result, efficiency (400 µg mL −1 ) mostly optimized 1.0 HEA‐NPs in marine nutrient medium, which is worst‐case scenario antimicrobial material, can be improved 81% 97.4% under 30 min solar irradiation (1 sun). The present study demonstrates new strategy effectively treating microorganisms that cause biofouling microbial corrosion using characteristics as an auxiliary.
Language: Английский
Citations
49
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 23, 2024
Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.
Language: Английский
Citations
34
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Language: Английский
Citations
34
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2298 - 2316
Published: Jan. 26, 2024
Bacterial infection hampers wound repair by impeding the healing process. Concurrently, inflammation at site triggers production of reactive oxygen species (ROS), causing oxidative stress and damage to proteins cells. This can lead chronic wounds, posing severe risks. Therefore, eliminating bacterial reducing ROS levels are crucial for effective healing. Nanozymes, possessing enzyme-like catalytic activity, convert endogenous substances into highly toxic substances, such as ROS, combat bacteria biofilms without inducing drug resistance. However, current nanozyme model with single enzyme activity falls short meeting complex requirements antimicrobial therapy. Thus, developing nanozymes multiple enzymatic activities is essential. Herein, we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles (Ru-PC NPs) diverse aid infections. Under acidic conditions, due their glutathione (GSH) depletion peroxidase (POD)-like Ru-PC NPs combined H2O2 exhibit excellent antibacterial effects. in neutral environment, NPs, catalase (CAT) decompose O2, alleviating hypoxia ensuring sufficient supply. Furthermore, possess exceptional antioxidant capacity through superior superoxide dismutase (SOD) effectively scavenging excess nitrogen (RNS) environment. maintains balance system prevents inflammation. also promote polarization macrophages from M1 M2, facilitating More importantly, show good biosafety negligible toxicity. In vivo models have confirmed efficacy inhibiting promoting The focus this work highlights quadruple its potential reduce bacteria-infected
Language: Английский
Citations
30
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 1, 2024
Increasing bacterial infections and growing resistance to available drugs pose a serious threat human health the environment. Although antibiotics are crucial in fighting infections, their excessive use not only weakens our immune system but also contributes resistance. These negative effects have caused doctors be troubled by clinical application of antibiotics. Facing this challenge, it is urgent explore new antibacterial strategy. MXene has been extensively reported tumor therapy biosensors due its wonderful performance. Due large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, excellent adsorption reduction ability, shown potential for biopharmaceutical applications. However, there few antimicrobial evaluations on MXene. The current mechanisms mainly include physical damage, induced oxidative stress, photothermal photodynamic therapy. In paper, we reviewed MXene-based composites discussed guide further research field.
Language: Английский
Citations
27
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152513 - 152513
Published: May 23, 2024
Language: Английский
Citations
22
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 225 - 257
Published: May 7, 2024
The number of multi-drug-resistant bacteria has increased over the last few decades, which caused a detrimental impact on public health worldwide. In resolving antibiotic resistance development among different bacterial communities, new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing slow discovery functioning antibiotics. Advanced research studies have revealed significant disinfection potential two-dimensional nanomaterials (2D NMs) severed as effective antibacterial due their unique physicochemical properties. This review covers current progress 2D NMs-based based an inclusive explanation NMs' agents, including detailed introduction each possible well-known mechanism. properties NMs activities been deliberated while explaining toxic effects discussing biomedical significance, dysbiosis, cellular nanotoxicity. Adding challenges, we also discussed major issues regarding quality availability nanotoxicity data. However, smart advancements are required fabricate biocompatible exploit combat clinically.
Language: Английский
Citations
18
Nano Letters, Journal Year: 2024, Volume and Issue: 24(13), P. 4044 - 4053
Published: March 22, 2024
Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.
Language: Английский
Citations
17