Alkaline Phosphatase Activated Near-Infrared Frequency Upconversion Photosensitizers for Tumor Photodynamic Therapy DOI
Chao Zhao,

Wanlu Sun,

Xiaoyan Huang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(15), P. 13383 - 13391

Published: July 26, 2024

Photodynamic therapy (PDT) is a promising anticancer method due to its noninvasive features, high efficiency, and superior accuracy. The activated near-infrared upconversion photosensitizer has tissue penetration depth could be explicitly released with minimal side effects. Therefore, we designed synthesized series of Br-substituted compounds (NFh-Br) based on the hemicyanine dye. heavy atomic effect improves generation 1O2 luminous efficiency. Especially, NFh-Br11 exhibited an excellent rate under 808 nm excitation effectively killed tumor cells in vitro, alkaline phosphatase (ALP)-activatable (NFh-ALP) was obtained by modifying NFh-Br11. NFh-ALP ALP release NFh-Br11, which induces apoptosis outstanding effects vitro vivo. This work provide strategy for designing activatable photosensitizers.

Language: Английский

DNA-Targeting Bioactive Photosensitizer for Chemo-Photodynamic Therapy of Malignant Tumor DOI
Yu Tian, Li Wang,

Yunyun Qian

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 969 - 975

Published: Feb. 15, 2024

The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.

Language: Английский

Citations

11
Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies DOI Creative Commons

Wenxin Chou,

Tianzhen Sun,

Nian Peng

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2617 - 2617

Published: Nov. 11, 2023

Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors immune response. However, anti-tumor effects induced are influenced several factors, including localization of PSs in cells, concentration, fluence rate light, integrity function. In this review, we systematically summarize influence factors mediated PDT. Furthermore, update on combination other immunotherapy provided. Finally, future directions challenges immunity discussed.

Language: Английский

Citations

16
A Bioactive Photosensitizer for Hypoxia‐Tolerant Molecular Targeting‐Photo‐Immunotherapy of Malignant Tumor DOI

Lianfeng Fan,

Chuanjiang Jian,

Ling Li

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(12)

Published: Dec. 15, 2023

Abstract Photosensitizers (PSs) with effective reactive oxygen species generation ability against hypoxia are of great potential for clinical treatment malignant tumors. However, complex tumor microenvironment, such as antioxidative responses and immunosuppression, would ineluctably limit the efficiency photodynamic therapy (PDT). Herein, a molecular‐targeting photosensitizer QTANHOH is rationally designed histone deacetylases (HDACs‐targeting photo‐immunotherapy application. The PS displays excellent type‐I/II PDT performance, exhibiting significant phototoxicity toward cancer cells half maximal inhibitory concentration (IC 50 ) less than 10 n m in both normoxia conditions under blue laser irradiation. Moreover, bioactive compound could inhibit HDACs activate immune microenvironment to boost efficacy on immunocompetent BALB/c mice breast cancer, leading eradication solid inhibition metastasis. Notably, introduces an alternative strategy achieve superior phototherapy therapy.

Language: Английский

Citations

15
Advancements in molecular disassembly of optical probes: a paradigm shift in sensing, bioimaging, and therapeutics DOI Creative Commons

Karolina Saczuk,

Marta Dudek, Katarzyna Matczyszyn

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(9), P. 1390 - 1416

Published: Jan. 1, 2024

Molecular disassembly is pioneering a new route to refined diagnostic and therapeutic solutions. This approach breaks down self-assembled molecules, offering enhanced precision efficiency in various bio-oriented applications.

Language: Английский

Citations

5
Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor DOI

Xiaoqing Fu,

Yongkang Yao,

Qiang Liu

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Topological effect of an intramolecular split G-quadruplex on thioflavin T binding and fluorescence light-up DOI Creative Commons

Mengmeng Lv,

Jiangtao Ren, Erkang Wang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(12), P. 4519 - 4528

Published: Jan. 1, 2024

In this work, the topological effect on binding interaction between a G-quadruplex and thioflavin T (ThT) ligand was systematically investigated platform of an intramolecular split (Intra-SG). Distinct fluorescence changes from ThT were presented in presence distinct modes Intra-SG structures intriguing phenomenon target-induced light-up occurred for 2 : 10, 5 7 8 4. It validated that hybridization spacer target did not unfold G-quadruplex, but facilitated binding. Moreover, 3' guanine-rich fragment very susceptible to topology variation produced by bound strand. Additionally, bioanalytical method developed ultrasensitive gene detection, confirming utility ThT/Intra-SG complex as universal signal transducer. is believed results disclosed rules will inspire researchers develop many new DNA-based transducers future.

Language: Английский

Citations

4
Iridium(iii)-based minor groove binding complexes as DNA photocleavage agents DOI Creative Commons
Stephen Opeyemi Aderinto, Torsten John, Abdulmujeeb T. Onawole

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(17), P. 7282 - 7291

Published: Jan. 1, 2024

Transition metal complexes containing the qtpy ligand with high-energy excited states are reported. Binding studies duplex and quadruplex DNA showed a preference for Ir( iii ) as groove binders to structures.

Language: Английский

Citations

4
Promising G-Quadruplex-Targeted Dibenzoquinoxaline Type-1 Photosensitizer Triggers DNA Damage in Triple-Negative Breast Cancer Cells DOI Creative Commons
Xiao Zhang, Jingxin Wang, Ming-Hao Hu

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(7), P. 2174 - 2184

Published: June 20, 2024

G-quadruplexes (G4s) are potential drug targets in cancer treatment. However, the G4-targeted ligands seem to lack sufficient selectivity between tumors and normal tissues, appealing for a new modified anticancer strategy on basis of them. Type-1 photodynamic therapy (PDT) is promising possessing excellent spatiotemporal precision solid with hypoxic microenvironment. type-1 photosensitizers that target G4s induce situ photodamage have never been previously reported. In this study, we reported photosensitizer based G4-targeted, high-contrast fluorescent ligand (TR2). The subsequent studies demonstrated TR2 could transfer from lysosomes nuclei elevated G4 formation as well DNA damage upon irradiation. Notably, it was observed may not activate repair machinery irradiation, suggesting durable, strong effect inducing damage. Consequently, light-irradiated exhibited photocytotoxicity triple-negative breast cell proliferation (at nanomolar concentration) showed obvious inhibition growth three-dimensional (3D) tumor spheroids. Finally, RNA-seq analysis TR2-mediated PDT negative impact enhancing antitumor immunity pathways. Overall, study provided chemical tool image-guided PDT.

Language: Английский

Citations

4
Gas immnuo-nanomedicines fight cancers DOI Open Access
Mengchi Sun, Tianye Wang,

Yinmei Zhu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117595 - 117595

Published: Oct. 31, 2024

Certain gas molecules, including hydrogen (H

Language: Английский

Citations

4
Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis DOI Creative Commons

Guangxiao Yao,

Junfeng Miao,

Yingying Huo

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

It is highly desired to achieve Type-I photosensitizer (PS) overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy-atom-free PS T-BNCy5 presented by incorporating biotin-modified naphthalimide (NI) unit into meso-position of N-benzyl-functionalized, strongly photon-capturing pentamethine cyanine (Cy5) dye. Such molecular engineering induces rigid orthogonal geometry between NI and Cy5 units introducing an intramolecular sandwich-like π-π stacking assembly, which effectively promotes intersystem crossing (ISC) greatly extends triplet-state lifetime (τ = 389 µs), thereby markedly improving superoxide (O2 •-)-generating ability. In vitro assays reveal that specifically accumulates mitochondria, where it not only generates O2 •- under photoirradiation but also burst cytotoxic hydroxy radical (HO•) cascade biochemical reactions, ultimately triggering cell ferroptosis with IC50 value up ≈0.45 µm whether normoxia or hypoxia. vivo manifest that, benefiting from its biotin unit, displays strong tumor-targeting ability, after single PDT treatment, can ablate tumor almost completely be cleared body through biosafe urinary excretion, indicating potential for future clinical translation.

Language: Английский

Citations

0