Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 259 - 284
Published: Jan. 1, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 11, 2024
Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.
Language: Английский
Citations
24
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)
Published: Feb. 2, 2024
Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced
Language: Английский
Citations
19
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)
Published: Sept. 17, 2024
Abstract The overexpression of polyamines in tumor cells contributes to the establishment immunosuppressive microenvironment and facilitates growth. Here, it have ingeniously designed multifunctional copper‐piceatannol/HA nanopills (Cu‐Pic/HA NPs) that effectively cause total intracellular depletion by inhibiting synthesis, depleting polyamines, impairing uptake, resulting enhanced pyroptosis cuproptosis, thus activating a powerful immune response achieve anti‐tumor therapy. Mitochondrial dysfunction from overall not only leads surge copper ions mitochondria, thereby causing aggregation toxic proteins induce but also triggers accumulation reactive oxygen species (ROS) within which further upregulates expression zDHHC5 zDHHC9 promote palmitoylation gasdermin D (GSDMD) GSDMD‐N, ultimately inducing pyroptosis. Then occurrence cuproptosis is conductive remodel microenvironment, responses growth metastasis. This therapeutic strategy through comprehensive provides novel template for cancer immunotherapy.
Language: Английский
Citations
17
Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 564 - 576
Published: Aug. 24, 2024
Orthopedic and dental implantations under bacterial infection microenvironment face significant challenges in achieving high-quality bone-implant integration. Designing implant coatings that incorporate both immune defense anti-inflammation is difficult conventional single-functional coatings. We introduce a multifunctional nanointerface using zinc finger-inspired peptide-metal-phenolic nanocoating, designed to enhance osseointegration such conditions. Abaloparatide (ABL), second-generation anabolic drug for treating osteoporosis, can be integrated into the design of zinc-phenolic network constructed on surface (ABL@ZnTA). Importantly, phenolic-coordinated Zn
Language: Английский
Citations
11
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(12)
Published: Feb. 2, 2024
Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced
Language: Английский
Citations
10
Langmuir, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
The growing demand for energy storage batteries, driven by the need to alleviate global warming and reduce fossil fuel dependency, has led environmental concerns surrounding spent batteries. Efficient recycling of these batteries is essential prevent pollution recover valuable metal ions such as nickel (Ni2+), cobalt (Co2+), manganese (Mn2+). Conventional hydrometallurgical methods battery recycling, while effective, often involve harmful chemicals processes. Natural polyphenols offer a greener alternative due their ability coordinate with ions. However, optimizing polyphenol selection efficient recovery remains labor-intensive challenge. This study presents strategy combining natural green precipitants power GPT-4, large language model (LLM), enhance precipitation from By leveraging capabilities GPT-4 in processing, we enable dynamic, iterative collaboration between human researchers LLM, different experimental conditions. results show that tannic acid achieved rates 94.8, 96.7, 96.7% Ni2+, Co2+, Mn2+, respectively, outperforming conventional methods. integration enhances both efficiency accuracy process, ensuring sustainability minimizing secondary utilizing biodegradable materials. innovative demonstrates potential artificial intelligence-driven analysis chemistry address challenges, paving way more sustainable
Language: Английский
Citations
1
Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)
Published: Feb. 26, 2024
Hierarchical self-assembly from simple building blocks to complex polymers is a feasible approach constructing multi-functional smart materials. However, the polymerization process of often involves challenges such as design and drive external energy. Here, hierarchical with self-driven energy conversion capabilities based on p-aminophenol diethylenetriamine reported. Through β-galactosidase (β-Gal) specific activation self-assembly, intelligent assemblies (oligomer superpolymer) excellent photothermal fluorescent properties are dynamically formed in situ, thus sensitive multi-mode detection β-Gal activity realized. Based overexpression ovarian cancer cells, superpolymer specifically generated SKOV-3 cells achieve fluorescence imaging. The therapeutic ability oligomer (synthesized vitro) evaluated by subcutaneous model, showing satisfactory anti-tumor effects. This work expands construction through cascade assembly small molecules provides new methods for diagnosis treatment cancer.
Language: Английский
Citations
5
EES Catalysis, Journal Year: 2024, Volume and Issue: 2(2), P. 475 - 506
Published: Jan. 1, 2024
The emerging single-atom catalysts derived from biomass sources to date have been comprehensively summarized and discussed, including synthesis strategies, various precursors, catalytic applications, existing challenges, perspectives.
Language: Английский
Citations
4
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(44)
Published: Aug. 6, 2024
Abstract Cell therapies such as CAR−T have demonstrated significant clinical successes, driving the investigation of immune cell surface engineering using natural and synthetic materials to enhance their therapeutic performance. However, many these do not fully replicate dynamic nature extracellular matrix (ECM). This study presents a strategy that utilizes phase‐separated peptide coacervates decorate cells. We meticulously designed tripeptide, Fmoc−Lys−Gly−Dopa−OH (KGdelta; Fmoc=fluorenylmethyloxycarbonyl; delta=Dopa, dihydroxyphenylalanine), forms in aqueous solution via phase separation. These coacervates, mirroring separation properties ECM proteins, coat killer (NK) with assistance Fe 3+ ions create an outer layer capable encapsulating monoclonal antibodies (mAb), Trastuzumab. The antibody‐embedded coacervate equips NK cells ability recognize cancer eliminate them through enhanced antibody‐dependent cellular cytotoxicity (ADCC). work thus unique functionalization demonstrates its use displaying cancer‐targeting mAb for therapies, highlighting potential application field therapy.
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Covalent peptide assembly leverages robust covalent bonds and dynamic non-covalent interactions to provide enhanced stability introduce diverse functionalities. Nevertheless, it remains significantly challenging achieve modular control over the structural diversity functional complexity while elucidating how specific amino acid sequences contribute these processes. Here, systematic encoding of derivative characteristics is demonstrated through modularity enable precise both in assemblies. By systematically screening single substitutions pentapeptides using tyrosine crosslinking, a library constructs developed. Each construct tailored exhibit distinct properties, including charge repulsion, aggregation-induced quenching, disassembly behavior, redox responsiveness. The strategic manipulation sequence composition, individual assemblies combinatorial systems, enables programmable complexity. This approach yields various module-specific functions, frustrated growth, hierarchical hollow architecture formation, affinity enrichment, stimuli-responsive fluorescence signal amplification. work establishes framework for design materials with functionalities, advancing development next-generation multicomponent technologies characterized by unprecedented adaptability.
Language: Английский
Citations
0