Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

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Multifaceted Catalytic Glucose Depletion and Reactive Oxygen Species-Scavenging Nanoenzyme Composite Hydrogel for Facilitating Diabetic Bone Regeneration

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Regeneration of diabetic bone defects remains a formidable challenge due to the chronic hyperglycemic state, which triggers accumulation advanced glycation end products (AGEs) and reactive oxygen species (ROS). To address this issue, we have engineered bimetallic metal–organic framework-derived Mn@Co3O4@Pt nanoenzyme loaded with alendronate Mg2+ ions (termed MCPtA) regulate microenvironment recover osteogenesis/osteoclast homeostasis. Notably, Mn atom substitution in Co3O4 nanocrystalline structure could modulate electronic significantly improve SOD/CAT catalytic activity for ROS scavenging. By integration GOx-like Pt nanoparticles, MCPtA achieved effective multiple cascade performance that facilitated clearance glucose ROS. Furthermore, was encapsulated within glucose-responsive hydrogel cross-linked via borate ester bond, termed PAM, evaluate potential composite cranial defect repair rats. The vitro/vivo experiments as well RNA sequencing analysis demonstrated disrupt glucose-ROS-induced inflammation promoted osteogenesis angiogenesis, consequence, improving therapeutic effects regeneration. This study provided crucial insights into nanoenzyme-mediated microenvironmental regulation

Language: Английский

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Lubricating MXenzyme-based hybrid hydrogel reverses oxidative damage to alleviate osteoarthritis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148815 - 148815

Published: Jan. 19, 2024

Language: Английский

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Targeted Anti‐Inflammatory Nanozymes with Pro‐Angiogenic Activity for Myocardial Infarction Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Abstract Myocardial infarction (MI) poses a significant threat to human health. Current treatments emphasize early revascularization restore blood supply the myocardium, often overlooking extensive oxidative damage and autophagy dysfunction resulting from reactive oxygen species (ROS) release after MI. Therefore, timely effective interventions clear ROS in stages of MI are crucial for inhibiting pathological progression restoring cardiac function. This study constructed ROS‐responsive biomimetic nanoparticle (PNP@Nb 2 C‐MSN) by integrating niobium carbide MXenes (Nb C) onto mesoporous silica (MSN) coated with platelet membrane. During acute phase, these nanoparticles targeted delivered infarcted heart via intravenous injection. The MSN structure enhances scavenging capacity Nb C, eliminating excess infarct region stress progression. Silicon ions released further promote angiogenesis within region. PNP@Nb C‐MSN reduces inflammation downregulating NF‐κB pathway activating AMPK pathway, thereby blocking microenvironmental improving In vitro vivo results highlight therapeutic potential MI, offering promising treatment strategy.

Language: Английский

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MXene‐Mediated Catalytic Redox Reactions for Biomedical Applications

ChemPlusChem, Journal Year: 2024, Volume and Issue: 89(6)

Published: Feb. 15, 2024

Reactive oxygen species (ROS) play a crucial role in orchestrating myriad of physiological processes within living systems. With the advent materdicine, an array nanomaterials has been intricately engineered to influence redox equilibrium biological milieus, thereby pioneering distinctive therapeutic paradigm predicated on ROS-centric biochemistry. Among these, two-dimensional carbides, nitrides, and carbonitrides, collectively known as MXenes, stand out due their multi-valent multi-elemental compositions, large surface area, high conductivity, pronounced local plasmon resonance effects, positioning them prominent contributors ROS modulation. This review aims provide overview advancements harnessing MXenes for catalytic reactions various applications, including tumor, anti-infective, anti-inflammatory therapies. The emphasis lies elucidating mechanism involving both pro-oxidation anti-oxidation processes, underscoring redox-related applications facilitated by self-catalysis, photo-excitation, sono-excitation properties MXenes. Furthermore, this highlights existing challenges outlines future development trends leveraging ROS-involving disease treatments, marking significant step towards integration these into clinical practice.

Language: Английский

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MXene-based nanomaterials with enzyme-like properties for biomedical applications

Nanoscale Horizons, Journal Year: 2023, Volume and Issue: 8(10), P. 1333 - 1344

Published: Jan. 1, 2023

Recently, great progress has been made in nanozyme research due to the rapid development of nanomaterials and nanotechnology. MXene-based have gained considerable attention owing their unique physicochemical properties. They found high enzyme-like properties, such as peroxidase, oxidase, catalase, superoxide dismutase. In this mini-review, we present an overview recent nanozymes, with emphasis on synthetic methods, hybridization, bio-catalytic biomedical applications. The future challenges prospects nanozymes are also proposed.

Language: Английский

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Generating Reactive Oxygen Species by a Dual-Catalytic Metal–organic Framework-based Nanozyme against Drug-resistant Bacteria Infection

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(11), P. 5630 - 5642

Published: May 20, 2024

Oxidase-like artificial enzymes (AEs) are rapidly developing for their attractive reactive oxygen species (ROS)-generating capacity in biological applications. However, efficient strategies to improve the AE catalytic performance by modulating electron transfer (ET) process remain limited. Herein, a new pathway de novo-designed MOF-based oxidase mimics (ZCA-X) is reported. The structure of active center regulated form unique Au–N–Cu domain boosting ROS against drug-resistant bacteria. Unlike classical cascade systems depending on hydrogen peroxide or photocatalysts with complex regulation band structure, oxidase-like ZCA-20 catalyzes reduction via direct four-ET without simulation specific substrate. formed charge between Au NCs and CuN4 single site exhibits high efficiency (kcat = 3.61 s–1), generating as intermediate products. employed eradication bacteria ROS-mediated structural damage, showing remarkable therapeutic effects both vitro vivo. This strategy ET coupling different sites might inspire development AEs selectivity enzymatic activity.

Language: Английский

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A G-quadruplex-based method to detect ClO− in the rostral ventrolateral medulla of stress-induced hypertension by self-complementary DNA probe

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(5)

Published: April 10, 2025

Language: Английский

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MXenes in the application of diabetic foot: mechanisms, therapeutic implications and future perspectives

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 15, 2025

Language: Английский

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Carbon dots efficiently promote vascularization for enhanced repairing of orthopedic diseases with diabetic mellitus based on nanocatalytic medicine

Carbon, Journal Year: 2023, Volume and Issue: 217, P. 118617 - 118617

Published: Nov. 15, 2023

Language: Английский

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