Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158569 - 158569
Published: Dec. 1, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
Despite the proceeds in management of acute myocardial infarction (AMI), current therapeutic landscape still suffers from limited success clinic. Exaggerated inflammatory immune response and excessive oxidative stress are key pathological features aggravating myocardium damage. Herein, catalytic immunomodulatory nanocomplexes as anti-AMI therapeutics to resolve reactive oxygen species (ROS)-proinflammatory neutrophils-specific-inflammation is engineered. The contain lyophilic S100A8/9 inhibitor ABR2575 core nanoemulsions, which effectively disrupts neutrophils-S100A8/A9-inflammation signaling pathway AMI microenvironment. Additionally, ROS scavenger ultrasmall Cu
Language: Английский
Citations
3
Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111455 - 111455
Published: Aug. 30, 2024
Language: Английский
Citations
3
Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 26, 2024
Since the initial publication on first Ti3C2T x MXene in 2011, there has been a significant increase number of reports applications MXenes various domains. have emerged as highly promising materials for biomedical applications, including photothermal therapy (PTT), drug delivery, diagnostic imaging, and biosensing, owing to their fascinating conductivity, mechanical strength, biocompatibility hydrophilicity. Through surface modification, can mitigate cytotoxicity, enhance biological stability, improve histocompatibility, thereby enabling potential use vivo applications. are also known ability absorb light near-infrared (NIR) region generate heat by localised plasmon resonance (LSPR) effects electron-phonon coupling. Optical excitation laser pulses result hot photocarrier distribution MXenes, which quickly transfers surplus energy crystal lattice results internal conversion into with nearly 100% efficiency. The relaxation carrier interactions leads cooling dissipating thermal surrounding environment. This heating effect makes them agents (PTAs), particularly PTT adjustable high area-to-volume ratios ideal combinatorial approach along photodynamic (PDT), bone regeneration other non-Ti more biocompatible than Ti they candidates different comprehensive review provides concise overview current research patterns, properties, its approaches.
Language: Английский
Citations
3
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 565 - 579
Published: June 1, 2024
Foam cells play a pivotal role in the progression of atherosclerosis by triggering inflammation within arterial walls. They release inflammatory molecules that attract additional immune cells, leading to further macrophage recruitment and plaque development. In this study, we develop an osteopontin (OPN) antibody-conjugated niobium carbide (Nb2C-aOPN) MXenzyme designed selectively target mildly ablate foam while reducing microenvironment. This approach utilizes photonic hyperthermia decrease size enhancing cholesterol regulation through both passive outflow positive efflux. Nb2C-aOPN exhibits multiple enzyme-mimicking properties, including catalase, superoxide dismutase, peroxidase glutathione peroxidase, acts as scavenger for reactive oxygen nitrogen species. The inhibition species synergizes with photothermal ablation promote efflux, reduced shift phenotype from M1 M2. integrative strategy on anti-inflammation highlights potential multifunctional 2D MXenzyme-based nanomedicine advancing atherosclerotic regression.
Language: Английский
Citations
2
ChemMedChem, Journal Year: 2024, Volume and Issue: 19(21)
Published: July 10, 2024
Abstract In recent years, two‐dimensional transition metal carbides, nitrides, and carbonitrides, termed as MXenes, have been widely applied in energy storage, photocatalysis biomedicine owing to their unique physicochemical properties of large specific surface area, high electrical conductivity, excellent optical performance, good stability, etc. Moreover, due strong light absorption capacity the first second near‐infrared bio‐window, ability being simply functionalized with multiple organic/inorganic materials, MXene biomaterials shown great potential field catalytic therapy. This review will summarize common mechanism latest applications medicine such tumor therapy, antibacterial anti‐inflammatory, present current challenges opportunities clinical translation for future development promote advancement medicine.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)
Published: July 19, 2024
Current phototherapeutic approaches for Alzheimer's disease (AD) exhibit restricted clinical outcomes due to the limited physical penetration and comprised brain microenvironment of noninvasive nanomedicine. Herein, a hydrogen-bonded organic framework (HOF) based sonosensitizer is designed synthesized. Mn-TCPP, planar molecule where Mn
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23412 - 23427
Published: Aug. 15, 2024
Integrated diagnostic and therapeutic dressings are desirable to relieve diabetic patients who often suffer from foot ulcers (DFUs) peripheral vascular diseases (PVDs). However, it is highly difficult monitor the pulse waves with fidelity under wet environments connect waveforms through a small strain sensor. Additionally, immobilizing MXenzyme regulate spatially heterogeneous levels of reactive oxygen species (ROS) applying active intervention enhance ulcer healing on single structure remain complex task. To address these issues, we designed multiscale wearable dressing comprising knitted all-textile sensing array for quantitatively investigating wave toward PVD diagnosis. was loaded onto provide multiple enzyme mimics anti-inflammatory activities deliver electrical stimulation promote wound growth. In mice, demonstrate that high uniform expression endothelial growth factor (VEGF) observed only in group undergoing dual mediation MXenzyme. This observation indicates engineered has capability accelerate DFU. human patient evaluations, distinguishes compliance period, enabling diagnosis arteriosclerosis return blockage, two typical PVDs. The achieves purpose integrating vessel health monitoring therapeutics satisfying practical clinical requirements geriatric patients.
Language: Английский
Citations
2
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(19), P. 1572 - 1572
Published: Sept. 29, 2024
MXenes nanosheets with high conductivity, hydrophilicity, and excellent reactive oxygen species (ROS) scavenging ability have shown promise in treating various degenerative diseases correlated abnormal ROS accumulation. Herein, the therapeutic potential of Ti3C2Tx nanosheets, which is most widely investigated MXene material, delaying osteoarthritis (OA) progression demonstrated. In vitro experiments indicate strong capacity their acceptable biocompatibility. effectively protect chondrocytes from cell death induced by oxidative stress. addition, demonstrate a prominent anti-inflammatory effect to restore homeostasis between anabolic activities catabolic chondrocytes. Furthermore, RNA sequencing reveals mechanism underlying nanosheet-mediated effect. Finally, vivo curative verified using rat OA model. Histological staining immunohistochemical analyses that ameliorate progression. Conclusively, suggest could be promising effective option for treatment.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 16, 2024
Abstract Noise‐induced hearing loss (NIHL), a prevalent sensory disability affecting majority of the global population, is dominantly induced by mitochondrial dysfunction and oxidative stress, but no effective therapeutic strategy available. Herein, potential 2D catalytic niobium carbide (Nb 2 C) MXenzyme investigated as nanomedicine for treating NIHL scavenging reactive oxygen species (ROS). The findings reveal that Nb C effectively eliminates free radicals, resulting in substantial reduction ROS House Ear Institute‐Organ Corti 1 (HEI‐OC1) cells treated with hydrogen peroxide (H O ). Additionally, demonstrates significant protection on hair preventing cytotoxicity apoptosis H . In vivo experiments further support efficacy restoring impairment caused extensive noise exposure. Specifically, it restores raised amplitude Wave I auditory brainstem response (ABR) records promotes recovery damaged ribbon synapses inner cells. Notably, effect attributed to its ability suppress cochlear stress evidenced immunohistochemical analysis. This research provides new approach loss‐related ear diseases utilizing biomaterials enzyme‐mimicking properties.
Language: Английский
Citations
1
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: June 29, 2024
Language: Английский
Citations
1