Sulfur oxidation states manipulate excited state electronic configurations for constructing highly efficient organic type I photosensitizers DOI Creative Commons
Jianye Gong, Xiaopeng Wang, Weijing Zhang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(32), P. 13001 - 13010

Published: Jan. 1, 2024

The multiple relaxation processes of excited states are a bridge connecting molecular structures and properties, providing enormous application potential for organic luminogens. However, systematic understanding manipulation the relationship between structure, state processes, properties luminogens is still lacking. Herein, we report strategy manipulating electronic configurations through regulation sulfur oxidation to construct eminent type I PSs. Combined with experimental results theoretical calculations, have successfully revealed decisive role high in promoting ROS production capacity. Impressively, higher can reduce singlet-triplet energy gap (Δ

Language: Английский

Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy DOI
Yuanyuan Zhao, Heejeong Kim, Nguyễn Văn Nghĩa

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

Citations

54
Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy DOI Creative Commons

Wenli Ma,

Yanyang Wang,

Yilin Xue

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(11), P. 4019 - 4030

Published: Jan. 1, 2024

This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .

Language: Английский

Citations

18
Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field DOI Creative Commons
Qian He,

Meiyiming Wang,

Zhao Li

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

Citations

17
ROS-responsive and triple-synergistic mitochondria-targeted polymer micelles for efficient induction of ICD in tumor therapeutics DOI Creative Commons
Xiaoxiao Hu, Mo Zhang,

Cuilu Quan

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 490 - 507

Published: June 1, 2024

Immunogenic cell death (ICD) represents a modality of apoptosis distinguished by the emanation an array damage-related molecular signals. This mechanism introduces novel concept in field contemporary tumor immunotherapy. The inception reactive oxygen species (ROS) within cells stands as essential prerequisite and foundation for ICD induction. formulation highly efficacious photodynamic therapy (PDT) nanomedicines successful induction is area significant scientific inquiry. In this work, we devised ROS-responsive triple-synergistic mitochondria-targeted polymer micelle (CAT/CPT-TPP/PEG-Ce6, CTC) that operates with multistage amplification ROS to achieve potent ICD. Utilizing "all-in-one" strategy, direct both PDT chemotherapeutic units mitochondria. Concurrently, cyclical caused triple synergy strategy stimulates continuous, stable, adequate generation (domino effect) mitochondria cells. Conclusively, influenced ROS, cell-induced effectively activated, remodeling immunogenicity, enhancing therapeutic impact when synergized chemotherapy. Empirical evidence from vitro study substantiates CTC micelles can efficiently provoke ICD, catalyzing CRT translocation, liberation HMGB1 ATP. Furthermore, animal trials corroborate micelles, following tail vein injection, induce accumulate tissues, markedly inhibit growth subsequent laser irradiation. Finally, transcriptome analysis was carried out evaluate changes genome induced micelles. work demonstrates improve combination immunotherapy using nanotechnology.

Language: Английский

Citations

17
Molecular Engineering of Plasma Membrane and Mitochondria Dual‐Targeted NIR‐II AIE Photosensitizer Evoking Synergetic Pyroptosis and Apoptosis DOI Open Access
Jiabao Zhuang,

Zhedong Ma,

Nan Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: Nov. 22, 2023

Phototherapy provides a noninvasive and spatiotemporal controllable paradigm to inhibit the evasion of programmed cell death (PCD) tumors. However, conventional photosensitizers (PSs) often induce single PCD process, resulting in insufficient photodamage severely impeding their application scopes. In this study, molecular engineering is conducted by adjusting electron donors develop an aggregation-induced NIR-II emissive PS (DPITQ) for plasma membrane mitochondria dual-targeted tumor therapy evoking synergetic pyroptosis apoptosis. DPITQ displays boosted type I II reactive oxygen species generation as well high photothermal conversion efficacy (43%) after laser irradiation 635 nm. The excellent biocompatibility appropriate lipophilicity help specifically anchor cancer cells. Furthermore, photosensitized can disrupt intact cause mitochondrial dysfunction, ultimately causing concurrent apoptosis suppress proliferation even under hypoxia. It noteworthy that nanoparticles (NPs) present clear fluorescence imaging capability on venous vessels nude mice. Notably, NPs exert efficient imaging-guided phototherapy both multicellular spheroids vivo, maximum destruction tumors but minimum adverse effects normal tissue.

Language: Английский

Citations

29
Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies DOI Creative Commons

Luojia Chen,

Si‐Ling Chen,

Yuncong Yuan

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

Citations

10
Lipophilicity Modulation of Fluorescent Probes for In Situ Imaging of Cellular Microvesicle Dynamics DOI
Wei Huang, Guangmei Han, Dong Wang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Real-time monitoring of dynamic microvesicles (MVs), vesicles associated with living cells, is great significance in deeply understanding their origin, transport, and function. However, specific labeling MVs poses a challenge due to the lack unique biomarkers that differentiate them from other cellular compartments. Here, we present strategy selectively label by evaluating series lipid layer-sensitive cationic indolium-coumarin fluorescent probes (designated as IC-Cn, n ranging 1 18) feature varying aliphatic side chains (CnH2n+1). Through situ cell imaging analysis, found IC-Cn location highly related lipophilicities phospholipid layer hydrophobic microenvironments In detail, IC-C1 IC-C2 specifically localize both inside outside cells. contrast, IC-C3, IC-C4, IC-C5 mitochondria but distinct fluorescence lifetimes. Using these strategically, have discovered that, addition biogenesis plasma membranes damaged mitochondria, newly formed can undergo fusion fission processes. Moreover, mitochondria-derived MVs, beyond being released parent fuse lysosomes facilitate removal dysfunctional mitochondria. The work not only provides new insights into MV physiology also inspires design strategies for used studies.

Language: Английский

Citations

1
Near‐Infrared Emission Beyond 900 nm from Stable Radicals in Nonconjugated Poly(diphenylmethane) DOI
Ziteng Zhang, Zuping Xiong, Jianyu Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(24)

Published: April 9, 2024

Organic radicals with narrow energy gaps are highly sought-after for the production of near-infrared (NIR) fluorophores. However, current repertoire developed organic is notably limited, facing challenges related to stability and low fluorescence efficiency. This study addresses these limitations by achieving stable in nonconjugated poly(diphenylmethane) (PDPM). Notably, PDPM exhibits a well-balanced structural flexibility rigidity, resulting robust intra-/inter-chain through-space conjugation (TSC). The within PDPM, coupled strong TSC, yield remarkable full-spectrum emission spanning from blue NIR beyond 900 nm. extensive tunability achieved through careful adjustments concentration excitation wavelength. findings highlight efficacy polymerization stabilizing introduce novel approach developing emitters based on triphenylmethane subunits.

Language: Английский

Citations

7
A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy DOI
Minzi Ju, Lu Yang, Guowei Wang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(11), P. 2831 - 2840

Published: Jan. 1, 2024

A chemicobiology toolbox for type I and II photodynamic therapy.

Language: Английский

Citations

7
Aggregation-Induced Emission Photosensitizer with Ag(I)−π Interaction-Enhanced Reactive Oxygen Species for Eliminating Multidrug Resistant Bacteria DOI

Senlin Peng,

Jiayi Song,

Shouting Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30915 - 30928

Published: June 7, 2024

Multidrug-resistant (MDR) bacteria pose serious threats to public health due the lack of effective and biocompatible drugs kill MDR bacteria. Photodynamic antibacterial therapy has been widely studied its low induction resistance. However, photosensitizers that can efficiently generate reactive oxygen species (ROS) through both type I II mechanisms have capability multiple modes action are rarely reported. Addressing this issue, we developed a near-infrared-emitting triphenylamine indole iodoethane (TTII) silver(I) self-assembled (TTIIS) aggregation-induced emission (AIE) photosensitizer for multimode bacterial infection therapy. TTII produce Type ROS •OH 1O2. Interestingly, Ag(I)−π interaction contributed in TTIIS efficiency promotion generation Moreover, by releasing Ag+, enabled photodynamic-Ag(I) dual-mode sterilization. As result, achieved an enhancement activity, with 1–2-fold boost against multidrug-resistant Escherichia coli (MDR E. coli). Both at concentration as 0.55 μg mL–1 more than 98% methicillin resistant Staphylococcus aureus (MRSA) on MRSA-infected full-thickness defect wounds mouse, were eliminating promoting wound healing.

Language: Английский

Citations

7