Electrochemically Mediated Atom Transfer Radical Polymerization Driven by Alternating Current DOI Creative Commons
Francesco De Bon, Marco Fantin,

Vanessa A. Pereira

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: April 22, 2024

Alternating current (AC) and pulsed electrolysis are gaining traction in electro(organic) synthesis due to their advantageous characteristics. We employed AC electrochemically mediated Atom Transfer Radical Polymerization (eATRP) facilitate the regeneration of activator Cu

Language: Английский

Photo‐/Electrocatalytic Difunctionalization of Alkenes Enabled by C‐H Radical Functionalization DOI

Zilong Zhou,

Yin Zhang,

Peizhe Cui

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(62)

Published: Aug. 10, 2024

The difunctionalization of alkenes represents a powerful tool to incorporate two functional groups into the alkene bones for increasing molecular complexity and has been widely utilizations in chemical synthesis. Upon catalysis green, sustainable, mild photo-/electrochemistry technologies, much attentions have attracted development new tactics transformations important alkane feedstocks driven by C-H radical functionalization. Herein, we summarize recent advances photo-/electrocatalytic enabled We detailedly discuss substrate scope mechanisms reactions selecting impressive synthetic examples, which are divided four sections based on final terminated step, including oxidative radical-polar crossover coupling, reductive radical-radical transition-metal-catalyzed coupling.

Language: Английский

Citations

5
Electrochemical C‐O and C‐N Arylation using Alternating Polarity in Flow for Compound Libraries DOI Creative Commons
Jennifer Morvan,

Koen P. L. Kuijpers,

Dayne Fanfair

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Oct. 9, 2024

Abstract Etherification and amination of aryl halide scaffolds are commonly used reactions in parallel medicinal chemistry to rapidly scan structure–activity relationships with abundant building blocks. Electrochemical methods for etherification demonstrate broad functional group tolerance extended nucleophile scope compared traditional methods. Nevertheless, there is a need robust scale‐transferable workflows electrochemical compound library synthesis. Herein we describe platform automated synthesis C−X arylation (X=NH, OH) flow access libraries. A comprehensive Design Experiment (DoE) study identifies an optimal protocol which generates high yields across>30 scaffolds, diverse amines (including electron‐deficient sulfonamides, sulfoximines, amides, anilines) alcohols serine residues within peptides). Reaction sequences on commercially available equipment generate libraries anilines ethers. The unprecedented application potentiostatic alternating polarity essential avoid accumulating electrode passivation. Moreover, it enables be performed air, without supporting electrolyte reproducibility over consecutive runs. Our method represents powerful means independent using electrochemistry.

Language: Английский

Citations

5
Catalysis under electric-/magnetic-/electromagnetic-field coupling DOI

Canyu Hu,

Yueyue Dong,

Qianqi Shi

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

This review outlines recent advances in field-regulated catalysis and reveals the key role of dipole manipulation by electric/magnetic/electromagnetic fields.

Language: Английский

Citations

5
Selective electrochemical thiocyanation/selenocyanation of C(sp3)-H and C(sp2)-H bonds DOI
Zhihao Wang, Binbin Chen, Qing Pang

et al.

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 559, P. 114060 - 114060

Published: March 21, 2024

Language: Английский

Citations

4
Electrochemical Denitrative Cyclization Driven by Alternating Polarity DOI
Shu Zhu, Yichao Lin,

Guo-Cai Yuan

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Alternating current electrolysis has emerged as a promising technique for addressing challenging redox reactions that are otherwise difficult or impossible direct electrolysis. Under mild and transition-metal-free reaction conditions, general electrochemical denitrative cyclization of nitroarenes was developed to access various cyclic sulfone-containing derivatives biological significance. The key success lies in the facile manipulation multiple events upon rapid alternating polarity switching enhance selectivity efficiency.

Language: Английский

Citations

0
Stirring Effects on AC-Induced Chemoselectivity in Reversible Electrochemical Reactions DOI

Yong Rui Poh,

Joel Yuen-Zhou

The Journal of Physical Chemistry C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Manganese-Catalyzed Electrochemical Oxidation of Tryptophan-Containing Peptides and Indole Derivatives by O2 DOI
Min Xu, Qin He, Xiaojiang Li

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3928 - 3939

Published: Feb. 20, 2025

Language: Английский

Citations

0
Recent Advances toward Electro- and Electrophotochemical 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-Catalyzed C—H/C—F Bonds Functionalization DOI
Yongmei Li,

Liangbo Sun,

Kun Xu

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 668 - 668

Published: Jan. 1, 2025

Language: Английский

Citations

0
Electroreductively driven C–H functionalization of arenes DOI
Pengfei Xie,

Anzai Shi,

Youai Qiu

et al.

Chem Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 101359 - 101359

Published: April 1, 2025

Language: Английский

Citations

0
When transition-metal catalysis meets electrosynthesis: a recent update DOI
Fei Lian, Jiuling Li, Kun Xu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(22), P. 4390 - 4419

Published: Jan. 1, 2024

The merger of organic electrosynthesis with 3d transition-metal catalysis has offered huge opportunities for modern synthesis. This review summarizes the key advancements in this direction published recent two years.

Language: Английский

Citations

3