Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(28)
Published: April 15, 2024
With
halogen-atom
transfer
as
an
effective
tool,
a
novel
catalytic
enantioselective
protocol
to
generate
chiral
trifluoromethylated
alkynes
has
been
established
by
cooperative
photoredox
and
nickel
catalysis
system,
providing
straightforward
modular
route
access
this
type
of
product
in
good
yields
enantioselectivities.
The
process
is
essential
for
the
reaction
strategy
offers
another
promising
way
utilize
alkyl
halides
with
highly
negative
reduction
potentials.
It
firstly
expands
nickel-catalyzed
asymmetric
reductive
cross-couplings
organohalides
from
traditional
single-electron
transfer.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(42), P. 29177 - 29188
Published: Oct. 12, 2024
Tertiary
alkylamines
are
privileged
structural
motifs
widely
present
in
natural
products,
pharmaceutical
agents,
and
bioactive
molecules,
their
efficient
synthesis
has
been
a
longstanding
goal
organic
chemistry.
The
functionalization
of
α-amino
radicals
derived
from
abundant
precursors
represents
an
emerging
approach
to
accessing
alkylamines,
but
application
this
strategy
obtain
tertiary
remains
challenging.
Here,
we
show
that
dual
photoredox/nickel
catalysis
enables
aminoalkylation
organohalides
(sp
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
14(1), P. 547 - 553
Published: Dec. 26, 2023
Direct
transformations
of
readily
available
amines
or
amides
via
C–H
bond
functionalization
could
provide
a
fast
route
for
accessing
complex
molecules.
While
various
groups
have
been
successfully
incorporated
into
the
α
position
nitrogen
atom
with
photoredox
system
activation,
couplings
functionalized
alkyl
halides
are
still
very
challenging.
Herein,
we
report
direct
and
convenient
protocol
β-amino
boronates
through
C(sp3)–C(sp3)
coupling
α-bromoboronates.
The
mild
conditions
allow
good
functional
group
tolerance
broad
scope.
application
method
in
late-stage
modification
molecules
further
demonstrates
its
great
potential
organic
synthesis.
Mechanistic
studies
were
also
conducted,
catalytic
cycle
is
proposed.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(24), P. 26708 - 26718
Published: June 4, 2024
Y–H
bond
functionalization
has
always
been
the
focus
of
research
interest
in
area
organic
synthesis.
Direct
hydrogen
atom
transfer
(HAT)
from
is
one
most
efficient
and
practical
methods
to
activate
bond.
Recently,
nitrogen
centered
radical
cations
were
broadly
utilized
as
H-abstraction
catalysts
bonds
via
HAT
process.
As
a
type
catalyst,
H-affinity
significant
thermodynamic
parameter
quantitatively
evaluate
potentials
cations.
In
this
work,
pKa
values
120
protonated
N-containing
compounds
acetonitrile
(AN)
are
predicted,
H-affinities
AN
derived
reduction
using
Hess'
law.
This
work
focuses
on
abilities
enrich
molecule
library
novel
or
H-abstractors
provides
valuable
guidelines
for
application
functionalization.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(19), P. 2323 - 2328
Published: May 22, 2024
Comprehensive
Summary
A
novel
visible‐light‐induced
radical
cascade
6‐
endo
cyclization
of
dienes
(
N
‐(2‐vinylphenyl)acryl
amides)
is
developed
utilizing
α‐carbonyl
bromides
as
alkyl
reagents.
This
approach
affords
an
efficient
way
for
synthesizing
six‐membered
benzo‐fused
lactam
derivatives
with
chemo‐
and
regio‐selectivity
good
functional
group
tolerance.
Primary,
secondary,
tertiary
are
well‐compatible
this
reaction.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(20), P. 2479 - 2484
Published: June 21, 2024
Comprehensive
Summary
Traditional
reduction
coupling
reactions
of
two
bromides
typically
rely
on
transition
metal
catalysis.
Here,
we
introduce
the
development
a
visible‐light
catalytic
direct
reaction
between
α
‐CF
3
‐alkyl
and
alkynyl
to
access
valuable
organic
frameworks.
Our
research
confirms
excellent
compatibility
this
with
various
functional
groups,
which
could
be
used
modify
substrate
biologically
active
molecular
fragments.
Mechanistic
investigations,
including
control
experiments,
fluorescence
quenching
studies,
light‐switching
have
provided
insights
into
mechanism.
This
study
paves
way
for
application
catalysis
in
diverse
synthetic
transformations,
offering
sustainable
efficient
approach
synthesis.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
Azomethines
is
a
class
of
compounds,
which
have
traditionally
served
as
electrophilic
substrates,
but
their
reactions
with
radicals
long
been
limited.
Photocatalysis
provided
ample
opportunities
for
promoting
these
reactions,
wide
variety
reagents
serving
precursors
radicals.
Besides
regular
addition
mode
at
the
azomethine
fragment,
oxidative
pathway,
in
C=N
bond
remains
product,
has
become
possible
by
proper
selection
redox
catalyst.
This
review
summarizes
new
developments
this
rapidly
developing
field
over
past
five
years.
New
concepts
on
activation
towards
radical
attack
are
discussed.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(28)
Published: April 15, 2024
Abstract
With
halogen‐atom
transfer
as
an
effective
tool,
a
novel
catalytic
enantioselective
protocol
to
generate
chiral
trifluoromethylated
alkynes
has
been
established
by
cooperative
photoredox
and
nickel
catalysis
system,
providing
straightforward
modular
route
access
this
type
of
product
in
good
yields
enantioselectivities.
The
process
is
essential
for
the
reaction
strategy
offers
another
promising
way
utilize
alkyl
halides
with
highly
negative
reduction
potentials.
It
firstly
expands
nickel‐catalyzed
asymmetric
reductive
cross‐couplings
organohalides
from
traditional
single‐electron
transfer.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(38), P. 15835 - 15840
Published: Jan. 1, 2024
We
have
developed
2
H
-thiazolo[4,5-
d
][1,2,3]triazole
(ThTz),
an
unprecedented
[5-5]-fused
heteroaromatic
system
for
medicinal
chemistry.
C5-sulfonylated
ThTz
has
been
commercialized
through
Tokyo
Chemical
Industry
Ltd
(TCI:
catalogue
number
M3881).
