Dendrimer-Mediated Generation of a Metal-Phenolic Network for Antibody Delivery to Elicit Improved Tumor Chemo/Chemodynamic/Immune Therapy DOI
Zhiqiang Wang, Yunqi Guo, Gaoming Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

To simplify the composition and improve efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to deliver programmed death ligand-1 (PD-L1) antibody (anti-PD-L1) for combined tumor chemo/chemodynamic/immune therapy. Here, generation 5 poly(amidoamine) dendrimers conjugated with gossypol (Gos) through boronic ester bonds were used as a synthetic polyphenol coordinate Mn2+, then complexed anti-PD-L1 obtain nanocomplexes (for short, DPGMA). The prepared DPGMA exhibited good water dispersibility hydrodynamic size 166.3 nm tumor-microenvironment-responsive drug release behavior. integration Gos Mn2+ within resulted in significant inhibition immunogenic cell activation Gos-mediated chemotherapy Mn2+-catalyzed chemodynamic therapy, respectively, thereby leading dendritic maturation due role played mediate stimulator interferon genes (STING) pathway. Moreover, promoted recognition uptake by PD-L1-overexpressed tumors targeting, achieving combinational therapy mouse melanoma model, where immunotherapy modes three parts via chemotherapy/CDT-mediated ICD, Mn2+-mediated STING activation, antibody-mediated immune checkpoint blockade. With Mn2+-endowed r1 relaxivity (1.38 mM–1 s–1), can also be MR imaging. dendrimer-mediated may developed advanced nanomedicine tackle other cancer types.

Language: Английский

Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing DOI Creative Commons

Rongxin Yu,

Hongping Chen, Jian He

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Language: Английский

Citations

84
Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications DOI Creative Commons
Wanjun Xu, Zhixing Lin, Shuaijun Pan

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(45)

Published: Oct. 6, 2023

Coordination assembly offers a versatile means to developing advanced materials for various applications. However, current strategies assembling metal-organic networks into nanoparticles (NPs) often face challenges such as the use of toxic organic solvents, cytotoxicity because synthetic ligands, and complex synthesis procedures. Herein, we directly assemble NPs using metal ions polyphenols (i.e., metal-phenolic (MPNs)) in aqueous solutions without templating or seeding agents. We demonstrate role buffers (e.g., phosphate buffer) governing NP formation engineering physicochemical properties tunable sizes from 50 270 nm) by altering conditions. A library MPN is prepared natural ions. Diverse functional cargos, including anticancer drugs proteins with different molecular weights isoelectric points, are readily loaded within applications biocatalysis, therapeutic delivery) direct mixing, surface modification, owing strong affinity guest molecules. This study provides insights mechanism complexes simple strategy engineer nanosized desired diverse biotechnological

Language: Английский

Citations

58
Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials DOI Creative Commons
Xiaohang Guo, Weikang Luo,

Lingyu Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Language: Английский

Citations

48
Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease DOI
Qinglian Hu, Jingyu Li, Tong Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12917 - 12932

Published: May 9, 2024

Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of broad bioactivity high compatibility polyphenols, there is considerable interest developing a polyphenol-based collaborative platform remodel IBD regulate microbiota. Here, we demonstrated coordination assembly nanostructured polyphenols modify probiotics simultaneously deliver drugs for treatment. Inspired by distinctive structure tannic acid (TA), fabricated pBDT-TA using self-polymerizable aromatic dithiol (BDT) TA, which exhibited excellent antioxidant anti-inflammatory capability vitro. We thus coated sodium alginate (SA) surface Escherichia coli Nissle 1917 layer construct EcN@SA-pBDT-TA. The modified showed improved resistance oxidative inflammatory stress, resulted superior colon accumulation retention model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate (DSS)-induced colitis controlling response, repairing barriers, modulating gut Importantly, EcN@SA-pBDT-TA-mediated drug delivery achieve an therapeutic effect DSS Given availability functionality polyphenol prebiotics, expected that polyphenol-modified provided solution develop

Language: Английский

Citations

30
Metal–phenolic network composites: from fundamentals to applications DOI Creative Commons
Zhixing Lin, Hai Liu, Joseph J. Richardson

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10800 - 10826

Published: Jan. 1, 2024

This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components ( e.g. , drugs, proteins)—for various applications across diverse disciplines.

Language: Английский

Citations

29
Upcycling spent lithium-ion battery cathodes into cobalt-polyphenol networks by DES dissolution and solvent-induced crystallization DOI
Zeyu Wang, Yu Chen,

Fengyi Zhou

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(10), P. 5988 - 5996

Published: Jan. 1, 2024

A strategy is proposed to induce the self-assembly process of metal ions with polyphenol in deep eutectic solvents (DESs) for generation metal-polyphenol network particles (MPNPs).

Language: Английский

Citations

24
Bioinspired Adhesive Hydrogel Platform with Photothermal Antimicrobial, Antioxidant, and Angiogenic Properties for Whole-Process Management of Diabetic Wounds DOI

Peirong Zhou,

Chuankai Zhang,

Zihan Rao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, angiogenic properties. A composite (termed AQTGF) using poly(acrylic acid) (PAA) quaternized chitosan (QCS) as backbone materials loaded TA-Gd/Fe-bimetallic-phenolic coordination polymer was prepared. AQTGF displayed favorable mechanical properties, self-healing capabilities, adhesion characteristics, response performance. vitro experiments demonstrated that exhibits excellent antimicrobial capacity angiogenic, M2 macrophage phenotype polarizing addition, rat tail amputation liver hemostasis had Moreover, vivo studies have indicated can facilitate accelerating epidermal growth, promoting collagen deposition, modulating polarization, inhibiting inflammation, angiogenesis. conclusion, study provides adaptable holds promise treatment chronic wounds.

Language: Английский

Citations

3
Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks DOI Creative Commons
Zhengming Tang, Zhijie Huang, Yisheng Huang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 2, 2025

Metal-phenolic networks (MPNs), which comprise supramolecular amorphous formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis cumulative research advancements and utilizations MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate characteristic polyphenols, their intricate interaction modalities MPNs. Subsequently, it elucidates merits demerits diverse methodologies employed for MPNs, alongside exploring potential functional attributes. Furthermore, consolidates applications across various nanomedical domains encompassing tumor therapy, antimicrobial interventions, medical imaging, among others. Moreover, meticulous exposition journey from ingress into human body eventual excretion is provided. Lastly, persistent challenges promising avenues pertaining are delineated. Hence, offering on current nanomedicine, consequently indirect insights clinical implementation.

Language: Английский

Citations

3
Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties DOI
Hongxiang Mei, Hai Liu,

Chuanlu Sha

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13573 - 13584

Published: March 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Language: Английский

Citations

17
Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways DOI

Zhendong Liu,

Sainan Liu,

Bin Liu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 16, 2024

Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.

Language: Английский

Citations

15