Graphical Abstract: Angew. Chem. Int. Ed. 50/2023 DOI Open Access
Zhonglong Zhao, Jiangwei Zhang, Qin Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(50)

Published: Dec. 6, 2023

An s-block potassium

Language: Английский

Selenium chemistry for spatio-selective peptide and protein functionalization DOI
Zhenguang Zhao, Shay Laps, Jacob S. Gichtin

et al.

Nature Reviews Chemistry, Journal Year: 2024, Volume and Issue: 8(3), P. 211 - 229

Published: Feb. 22, 2024

Language: Английский

Citations

18
Therapeutic stapled peptides: Efficacy and molecular targets DOI Creative Commons

Yulei Li,

Ming‐Hao Wu,

Yinxue Fu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107137 - 107137

Published: March 23, 2024

Peptide stapling, by employing a stable, preformed alpha-helical conformation, results in the production of peptides with improved membrane permeability and enhanced proteolytic stability, compared to original peptides, provides an effective solution accelerate rapid development peptide drugs. Various reviews present stapling chemistries, anchoring residues one- or two-component cyclization, however, therapeutic stapled have not been systematically summarized, especially focusing on various disease-related targets. This review highlights latest advances drug facilitated application technology, including different techniques, synthetic accessibility, applicability biological targets, potential for solving problems, as well current status development. Stapled candidates classified analysed mainly receptor- ligand-based design against diseases, cancer, infectious inflammation, diabetes. is expected provide comprehensive reference rational diseases targets facilitate pharmacokinetic properties.

Language: Английский

Citations

14
A novel MoS2/GA electrode based on hybrid capacitive deionization technology for ion removal in polypeptide solution DOI
Hongliang Li, Zhengliang Gong, Dongya Ma

et al.

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132658 - 132658

Published: March 1, 2025

Language: Английский

Citations

0
Evaluation of selenocysteine contents in Se-enriched yogurt by Utilizing online post column derivative − High-Performance liquid chromatography DOI

Witchapol Thosaikham,

Anut Chantiratikul,

Kunlanan Wongtawarat

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 111872 - 111872

Published: Oct. 10, 2024

Language: Английский

Citations

1
Synthetic electrochemistry for peptides DOI
Yohei Okada, Kazuhiro Chiba

Current Opinion in Electrochemistry, Journal Year: 2024, Volume and Issue: 45, P. 101469 - 101469

Published: March 7, 2024

Language: Английский

Citations

1
Stabilization of 310-Helices in Macrocycles Using Dominant Rotor Methodology DOI

Martynas J. Širvinskas,

George J. Saunders,

Monica Mitrache

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(34), P. 24085 - 24093

Published: Aug. 19, 2024

Stabilization of biologically relevant structural motifs has been a long-standing challenge. Here we show that atropisomeric dominant rotors can stabilize rare 3

Language: Английский

Citations

0
Graphical Abstract: Angew. Chem. Int. Ed. 50/2023 DOI Open Access
Zhonglong Zhao, Jiangwei Zhang, Qin Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(50)

Published: Dec. 6, 2023

An s-block potassium

Language: Английский

Citations

0