Decarboxylation in Natural Products Biosynthesis
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(8), P. 2715 - 2745
Published: July 25, 2024
Decarboxylation
reactions
are
frequently
found
in
the
biosynthesis
of
primary
and
secondary
metabolites.
Decarboxylase
enzymes
responsible
for
these
transformations
operate
via
diverse
mechanisms
act
on
a
large
variety
substrates,
making
them
appealing
terms
biotechnological
applications.
This
Perspective
focuses
occurrence
decarboxylation
natural
product
provides
perspective
their
applications
biocatalysis
fine
chemicals
pharmaceuticals.
Language: Английский
Photobiocatalysis: More than just an interesting lab curiosity?
Chem Catalysis,
Journal Year:
2024,
Volume and Issue:
4(10), P. 101077 - 101077
Published: Aug. 23, 2024
Language: Английский
Transitioning enzyme catalysis towards photocatalysis
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences,
Journal Year:
2025,
Volume and Issue:
383(2296)
Published: May 8, 2025
Enzyme
biocatalysis
is
being
industrialized
at
a
phenomenal
rate.
Biocatalysis
offers
routes
to
chemical
transformations
that
avoid
the
use
of
expensive
metal
catalysts,
high
temperatures
and
pressures,
while
providing
impressive
enantio-,
regio-
chemo-selectivities.
Working
individually
or
as
cascades,
in
live
cells
cell-free
preparations,
manufacture
everyday
chemicals,
materials,
healthcare
products,
fuels
pharmaceuticals
diagnostic
industrial
sensing
applications,
enzymes
are
key
enablers
circular
bioeconomy.
An
ability
exploit
tailor
biocatalysts
rapidly
predictably
requires
knowledge
structure-mechanism
relationships
physical
chemistry
enzyme
action.
This
has
advanced
since
our
millennium
article
on
this
topic
(Sutcliffe
Scrutton
Phil
Trans
R.
Soc.
Lond.
A
.
2000.
358,
367–386).
Here,
we
discuss
an
emerging
frontier—enzyme
photobiocatalysis.
Photoenzymes
rarely
found
nature.
limits
'difficult-to-achieve'
reactions
biology
generally
accessible
photocatalysts.
We
here
emergence
photobiocatalysis
new
frontier.
review
natural
photoenzymes
identify
challenges
limitations
their
photobiocatalysts.
consider
reports
repurposing
also
prospects
for
de
novo
design
photobiocatalysts
which
general
concept
would
transform
catalysis
science.
part
theme
issue
‘Science
into
next
millennium:
25
years
on’.
Language: Английский
Spatially Ordered Immobilization of Cascade Enzymes for the Construction of a Robust Colorimetric Hydrogel Sensor
Biosensors and Bioelectronics,
Journal Year:
2024,
Volume and Issue:
270, P. 116939 - 116939
Published: Nov. 14, 2024
Language: Английский
Biocatalytic Formal Asymmetric para-Aminoethylation of Unprotected Phenols to Chiral Amines
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
15(1), P. 81 - 90
Published: Dec. 13, 2024
Enantiomerically
pure
amines
are
vital
for
the
development
of
biologically
active
compounds
in
medicine
and
agriculture.
While
aminoalkylation
phenols
is
well-established
creating
nitrogen-containing
frameworks,
regio-
stereoselective
para-aminoethylation
unprotected
underexplored.
To
fill
this
gap,
we
propose
a
one-pot
cascade
biocatalysis
system
asymmetric
into
chiral
amines,
using
simple
pyruvate,
NH4Cl,
D/l-alanine
as
starting
materials.
Utilizing
modular
approach,
successfully
performed
through
sequential
process
vinylation
hydroamination,
achieving
good
conversions
(51.0–72.0%)
>99%
ee
both
enantiomers
amines.
Additionally,
biobased
p-hydroxycinnamic
acid
l-tyrosine
their
derivatives
were
converted
with
moderate
to
(39.4–87%)
integrating
decarboxylation/hydroamination
deamination-decarboxylation/hydroamination.
This
marks
successful
de
novo
biosynthesis
method
formal
phenols.
Language: Английский