Rapid CO2 Coupling to Propargylic Alcohols: Unlocking the Production of α-Alkylidene Cyclic Carbonates via Continuous Flow DOI
Pierre Stiernet, Alexandre Verdin,

Maja Stina Svanberg Frisinger

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 27(3), P. 722 - 730

Published: Dec. 4, 2024

Silver N-heterocyclic carbene complex unlocks the fast coupling of CO 2 to propargylic alcohols produce α-alkylidene cyclic carbonates through continuous flow process.

Language: Английский

On Sustainability Aspects of the Synthesis of Five-Membered Cyclic Carbonates DOI

Federico Mundo,

Sylvain Caillol, Vincent Ladmiral

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(17), P. 6452 - 6466

Published: April 15, 2024

The synthesis of cyclic carbonates, substrates gaining growing interest due to their broad spectrum applications, is analyzed from a Green Chemistry perspective. Extensive research has been carried out on the these substances, which are especially for preparation so-called non-isocyanate polyurethanes (NIPUs). Often, renewability raw materials, derived instance carbon dioxide, diols, urea, or alkyl taken into account, without considering sustainability aspects protocols. In this review, we employ E-factors and discuss basic toxicity information compare numerous approaches data reported in literature synthesizing most common carbonates provide useful, although not exhaustive, first evaluation. This study highlights that achieve more sustainable manufacture starting materials be matched with safer chemicals mild efficient reaction protocols order limit environmental impact synthesis.

Language: Английский

Citations

14
A thermally responsive phase-change hydrogel for skin-mountable multifunctional sensors DOI
Peng Wang,

Yu Lv,

Jingle Duan

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110722 - 110722

Published: Jan. 1, 2025

Language: Английский

Citations

1
New Opportunities for Organic Synthesis with Superheated Flow Chemistry DOI Creative Commons
Pauline Bianchi, Jean‐Christophe M. Monbaliu

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(15), P. 2207 - 2218

Published: July 23, 2024

ConspectusFlow chemistry has brought a fresh breeze with great promises for chemical manufacturing, yet critical deterrents persist. To remain economically viable at production scales, flow processes demand quick reactions, which are actually not that common. Superheated technology stands out as promising alternative poised to confront modern challenges. While continuous micro- and mesofluidic reactors offer uniform heating rapid cooling across different operating above solvent boiling points (i.e., under superheated conditions) significantly enhances reaction rates. Despite the energy costs associated high temperatures, aligns sustainability goals by improving productivity (process intensification), offering flexibility, enhancing safety.However, navigating unconventional space of can be cumbersome, particularly neophytes. Expanding temperature/pressure process window beyond conventional point atmospheric pressure limit vastly increases optimization space. When trial-and-error approaches, this become exceedingly wasteful, resource-intensive, discouraging. Over years, chemists have developed various tools mitigate these challenges, an increased reliance on statistical models, artificial intelligence, experimental (kinetics, preliminary test reactions microwave irradiation) or theoretical (quantum mechanics)

Language: Английский

Citations

4
Guanidium Unmasked: Repurposing Common Amide Coupling Reagents for the Synthesis of Pentasubstituted Guanidine Bases DOI Creative Commons

Juhana A. S. Aho,

Jere K. Mannisto, S Mattila

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Guanidines make up a class of compounds with important applications in catalysis and medicinal chemistry. In this systematic study, we report on the guanylation aliphatic amines, anilines, (sulfon)amides, ureas, carbamates by repurposing HATU, common amide coupling reagent. The products are 2-substituted 1,1,3,3-tetramethylguanidines (TMGs), group sterically hindered superbases. reaction guanidinium salt amines has been regarded as an unwanted side-reaction coupling, yet exact mechanistic details have unclear. Our investigation shows that is highly dependent nature nitrogen nucleophile. findings were applied two fronts: minimizing competing reactions well maximizing simple one-step synthesis broad variety TMGs, including late-stage functionalization pharmaceuticals.

Language: Английский

Citations

0
Trendbericht: Organische Chemie 2025 DOI Open Access
Martin Breugst, Jennifer N. Andexer,

Lena Barra

et al.

Nachrichten aus der Chemie, Journal Year: 2025, Volume and Issue: 73(3), P. 40 - 70

Published: Feb. 28, 2025

Abstract Highlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch Furanen zu Pyrrolen; mit Ammoniak primären Arylaminen; Metallschrott recyceln ionischen Flüssigkeiten; terminale Alkene Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente Alkaloide.

Citations

0
Non-isocyanate polyurethanes: perspectives as biomaterials DOI
Anna Pierrard, Sofia Ferreira Melo, Cécile Oury

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113985 - 113985

Published: May 1, 2025

Language: Английский

Citations

0
The Catalytic Coupling of CO2 and Glycidol toward Glycerol Carbonate DOI
Claire Muzyka, Diana V. Silva-Brenes, Bruno Grignard

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(16), P. 12454 - 12493

Published: Aug. 5, 2024

Ambitious environmental objectives have driven research and innovation toward the production of biorenewable chemicals, such as glycerol carbonate. In particular, carbonate from coupling CO2 glycidol has received considerable attention chemistry chemical engineering communities. This route became particularly appealing considering that is an activated derivative glycerol, which, together with CO2, industrial waste. To keep chain value high value-added attractive possible, numerous metal-based organo-catalysts been developed. We provide this review a pragmatic overview most promising catalytic protocols reported over past 8 years. Special given to inherent mechanistic structure-(re)activity features key parameters driving reaction performances. also addresses preparation selection catalysts, well global efficiency sustainability Such holistic intended feed inspiration for future highly efficient systems.

Language: Английский

Citations

2
A perspective on the synthetic potential of biobased building blocks for heterocyclic chemistry DOI

Loïc Bovy,

Jean‐Christophe M. Monbaliu

Advances in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 89 - 157

Published: Jan. 1, 2024

Language: Английский

Citations

0
Sustainable Upgrading of Glycerol into Glycidol and Its Derivatives Under Continuous-Flow Conditions DOI Creative Commons
Alessandra Sivo,

Ilaria Montanari,

Mert Can Ince

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(13), P. 7911 - 7918

Published: Jan. 1, 2024

This study develops a safe and efficient flow process to convert glycerol, biodiesel byproduct, into glycidol its derivatives. The method has significant environmental economic benefits compared conventional synthesis routes.

Language: Английский

Citations

0
Scalable Synthesis of Glycerol Carbonate Using Serially Connected Mesofluidic-Plate Reactors DOI
Yasuhiro Uozumi,

Kenji Tsukamoto

Synfacts, Journal Year: 2024, Volume and Issue: 20(07), P. 0782 - 0782

Published: June 14, 2024

Key words carboxylation - glycerol carbonate flow reactor guanidine base

Language: Английский

Citations

0