Polyphenol-Assisted Biomineralization of Metal–Organic Framework Nanoparticles for Precision Delivery of Therapeutic Proteins to Cancer Cells DOI

Tianli Luo,

Qizhen Zheng,

Ji Liu

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(5), P. 682 - 692

Published: April 22, 2024

The delivery of proteins into the cytosol holds great promise for cell signaling manipulation and development precision medicine. However, this potency is challenged by achieving targeted controlled delivery, specifically within diseased cells. In study, we introduce a versatile effective method therapeutic to cancer cells designing polyphenol-assisted biomineralization zeolite imidazole framework-8 (ZIF-8). We demonstrate that leveraging strong noncovalent binding affinity epigallocatechin gallate (EGCG) with both ZIF-8, our approach significantly enhances which in turn improves efficiency protein encapsulation intracellular delivery. Moreover, incorporation EGCG ZIF-8 enables degradation nanoparticles selective release encapsulated This triggered oxidation response high levels reactive oxygen species (ROS) found destabilize EGCG/ZIF-8 nanoparticles. have further demonstrated ability deliver wide range cells, including bacterial virulence protein, rewire prohibit tumor growth mouse xenograft model. Our strategy findings underscore potential interface specific therapy.

Language: Английский

Metal–phenolic network composites: from fundamentals to applications DOI Creative Commons
Zhixing Lin, Hai Liu, Joseph J. Richardson

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10800 - 10826

Published: Jan. 1, 2024

This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components ( e.g. , drugs, proteins)—for various applications across diverse disciplines.

Language: Английский

Citations

26
Modification of physicochemical, antioxidant, and antibacterial properties of chitosan film with curcumin-loaded TA/Fe nanoparticles DOI

Shuifang Mao,

Yujun Zeng, Yanming Ren

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 160, P. 110722 - 110722

Published: Oct. 11, 2024

Language: Английский

Citations

10
mRNA delivery enabled by metal–organic nanoparticles DOI Creative Commons
Yuang Gu, Jingqu Chen, Zhaoran Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 8, 2024

mRNA therapeutics are set to revolutionize disease prevention and treatment, inspiring the development of platforms for safe effective delivery. However, current delivery face some challenges, including limited organ tropism nonvaccine applications inflammation induced by cationic nanoparticle components. Herein, we address these challenges through a versatile, noncationic platform whereby is assembled into poly(ethylene glycol)-polyphenol network stabilized metal ions. Screening range components relative compositional ratios affords library stable, noncationic, highly biocompatible metal-organic nanoparticles with robust transfection in vitro mice. Intravenous administration lead mRNA-containing enables predominant protein expression gene editing brain, liver, kidney, while tuned varying composition. This study opens an avenue realizing nanoparticle-enabled delivery, offering modular approach assembling health applications.

Language: Английский

Citations

10
Carrier-Free Nanodrugs: From Bench to Bedside DOI

Fang Fang,

Xiaoyuan Chen

ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 23827 - 23841

Published: Aug. 20, 2024

Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading (even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are considered as one of the most promising candidates for disease theranostics. Substantial studies commercial success "carrier-free" nanocrystals have demonstrated their strong clinical potential. However, practical translations remain challenging impeded by unpredictable assembly processes, insufficient delivery efficiency, an unclear in vivo fate. In this Perspective, we systematically outline contemporary emerging carrier-free based on diverse APIs, well highlight opportunities challenges translation. Looking ahead, further improvements design preparation, drug delivery, efficacy, safety nanomedicines essential to facilitate translation from bench bedside.

Language: Английский

Citations

9
Bioinspired Assembly of Natural Polyphenol-Amino Acid Surfactants as Multifunctional Durable Coatings for Anticorrosion Fruit Packaging DOI
Ting Du, Li Xiang, Shuo Shi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Challenges emerge in the quest for highly efficient and biocompatible coatings to tackle microbial contamination. Here, we propose a bioinspired paradigm combining (-)-epigallocatechin gallate (EGCG) l-arginine surfactants (LAM) as all-green building blocks advanced with superior performance. Molecular dynamics simulations reveal natural assembly process of EGCG/LAM supramolecular nanoparticles (ELA NPs). Notably, retain 99.0% antimicrobial activity even after eight cycles use exhibit adhesive anti-water washing properties, maintaining their efficacy uses 30 days water soaking on various substrates. When applied sustainable food packaging perishable fruits at room temperature, ELA significantly extend shelf life strawberries cherry tomatoes, reducing weight loss firmness sweetness. This study demonstrates potential NPs versatile durable coating materials mitigating waste agricultural economic losses due pollution.

Language: Английский

Citations

1
Enabling ultrahigh loading of AIEgens through alkyne-amine click reactions for highly sensitive colorimetric-fluorescent dual-readout lateral flow immunoassay DOI
Yuankui Leng, Xiaolong Wang, Wenjing Li

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137473 - 137473

Published: Feb. 1, 2025

Language: Английский

Citations

1
Metal-Polyphenol Nanocomposite Hybrid Hydrogel: A Multifunctional Platform for Treating Diabetic Foot Ulcers through Metabolic Microenvironment Reprogramming DOI

Heng Gong,

Li Yang, Yaxing Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123414 - 123414

Published: May 17, 2025

Language: Английский

Citations

1
Supramolecular Assembly of Charge-Tunable Metal–Phenolic Networks DOI
Chan‐Jin Kim, Yuang Gu, Wanjun Xu

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Controlling the surface charge of nanoassembled structures enables modulation their physicochemical properties and expands applications. Metal–phenolic networks (MPNs) typically yield materials with negatively charged surfaces. Herein, MPNs tunable were prepared using biscatechol-functionalized poly(2-vinylpyridine) (P2VP) various metal ions. The first assembly route yielded P2VP–FeIII MPN capsules that displayed pH-dependent reversal (∼ −10 mV at pH 12 to 20 2) facilitated fabrication hollow superstructures. Besides catechol–metal interaction, pyridinyl nitrogen–metal coordination continuous P2VP–CoII (e.g., capsule shell thickness increased from 26 nm over 24 h). second involving concurrent quaternization P2VP produced positively (i.e., QP2VP/P2VP–FeIII capsules) provided control (12–52 nm) (6–53 mV) time (1–8 h) 70 °C. surfaces enabled bioactive fluorescent regulation cell association depending on degree positive charge. This work selection or building blocks for designing systems.

Language: Английский

Citations

0
Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies DOI Creative Commons

Yun-Mi Hur,

Kyoung‐Ik Min

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Covalent peptide assembly leverages robust covalent bonds and dynamic non-covalent interactions to provide enhanced stability introduce diverse functionalities. Nevertheless, it remains significantly challenging achieve modular control over the structural diversity functional complexity while elucidating how specific amino acid sequences contribute these processes. Here, systematic encoding of derivative characteristics is demonstrated through modularity enable precise both in assemblies. By systematically screening single substitutions pentapeptides using tyrosine crosslinking, a library constructs developed. Each construct tailored exhibit distinct properties, including charge repulsion, aggregation-induced quenching, disassembly behavior, redox responsiveness. The strategic manipulation sequence composition, individual assemblies combinatorial systems, enables programmable complexity. This approach yields various module-specific functions, frustrated growth, hierarchical hollow architecture formation, affinity enrichment, stimuli-responsive fluorescence signal amplification. work establishes framework for design materials with functionalities, advancing development next-generation multicomponent technologies characterized by unprecedented adaptability.

Language: Английский

Citations

0
Metal-Polyphenol Self-Assembled Nanophotothermal Agent for Precise Mitochondrial Targeted Photothermal Therapy DOI
Jun Zhou, Wensong Wang, Yong Li

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Nanocarriers have been extensively utilized to improve the stability of photothermal agents in vivo, enhance delivery efficiency, and reduce drug side effects. However, challenges, such as low safety carrier materials, insufficient loading therapeutic agents, complex preparation procedures, still persist. In this study, agent IR780 was encapsulated network TA-Fe3+ (TF) which self-assembled by tannic acid (TA) Fe3+ synthesize an acid-responsive multifunctional nanophotothermal TF@IR780 (TR). slightly acidic tumor microenvironment (TME), shell TF is degraded, internal exposed. On one hand, can solubility vivo significantly increase uptake efficiency cells. other exhibits magnetic resonance imaging (MRI) functionality, combined with fluorescence endows TR multimodal capabilities. addition, easy release photosensitizers through response pH environment TME, achieves precise damage mitochondria mitochondrial anchoring light regulation. This overcomes drawbacks traditional treatment methods, poor specificity, demonstrates efficient controllable antitumor activity.

Language: Английский

Citations

0