Photoelectrochemical synthesis of 4-halomethyl benzoxazines with a halogen anion source

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5553 - 5557

Published: Jan. 1, 2024

A mild and efficient protocol for preparing 4-halomethyl benzoxazines via a photoelectrochemical process with ammonium halide as the halogenating reagent was developed.

Language: Английский

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Substrate-Controlled Divergent Reductive Cyclization of 2-Arylanilines Using CO₂ as a Switching Reagent

Organic Letters, Journal Year: 2024, Volume and Issue: 27(1), P. 510 - 516

Published: Dec. 30, 2024

Capturing CO2 is highly valued in the field of organic synthesis, especially underdeveloped dual-CO2 conversion. In this study, we detail a novel reductive cyclization 2-indolylanilines with dual as difunctional reagent presence PMHS [poly(methylhydrosiloxane)], delivering methyl-substituted quinoxalines. Furthermore, another chemoselective 2-pyrrolylanilines also realized by converting mono-CO2. Mechanistic investigations shed light upon fact that substrate-controlled divergence mainly depends on formation N-diacylative intermediates.

Language: Английский

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Room‐Temperature Formate Ester Transfer Hydrogenation Enables an Electrochemical/Thermal Organometallic Cascade for Methanol Synthesis from CO2

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract The reduction of CO 2 to synthetic fuels is a valuable strategy for energy storage. However, the formation energy‐dense liquid such as methanol remains rare, particularly under low‐temperature and low‐pressure conditions that can be coupled renewable electricity sources via electrochemistry. Here, multicatalyst system pairing an electrocatalyst with thermal organometallic catalyst introduced, which enables at ambient temperature pressure. cascade synthesis proceeds formate by [Cp*Ir(bpy)Cl] + (Cp*=pentamethylcyclopentadienyl, bpy=2,2′‐bipyridine), Fischer esterification isopropyl catalyzed trifluoromethanesulfonic acid (HOTf), transfer hydrogenation facilitated (H‐PNP)Ir(H) 3 (H‐PNP=HN(C H 4 P i Pr ) ). isopropanol solvent plays several crucial roles: activating ion formate, donating hydrogen ester hydrogenation, lowering barrier through bonding interactions. In addition reporting method room‐temperature challenging substrates, this work provides prototype electrochemical reactions will guide design development cascades.

Language: Английский

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Coupling CO₂ Electroreduction to CO with alkyne Alkoxycarbonylation

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 8982 - 8987

Published: Oct. 16, 2024

The alkyne alkoxycarbonylation to α- or β-substituted acrylates was coupled with the electrocatalytic reduction of CO

Language: Английский

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