Highly Photoreactive Semiconducting Polymers with Cascade Intramolecular Singlet Oxygen and Energy Transfer for Cancer-Specific Afterglow Theranostics
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Afterglow
luminescence
provides
ultrasensitive
optical
detection
by
minimizing
tissue
autofluorescence
and
increasing
the
signal-to-noise
ratio.
However,
due
to
lack
of
suitable
unimolecular
afterglow
scaffolds,
current
agents
are
nanocomposites
containing
multiple
components
with
limited
performance
have
rarely
been
applied
for
cancer
theranostics.
Herein,
we
report
synthesis
a
series
oxathiine-containing
donor-acceptor
block
semiconducting
polymers
(PDCDs)
observation
their
high
photoreactivity
strong
near-infrared
(NIR)
luminescence.
We
reveal
that
PDCDs
absorb
NIR
light
undergo
photodynamic
process
generate
singlet
oxygen
(1O2),
which
intramolecularly
transfers
efficiently
reacts
oxathiine
form
intermediates
low
Gibbs
free
energy
changes
required
this
photoreaction.
Following
intramolecular
transfer
from
donor
acceptor
block,
emission
is
produced
PDCDs.
Owing
efficient
cascade
photochemical
process,
PDCD-based
nanoparticles
achieve
higher
brightness
longer
compared
most
reported
agents,
even
after
ultrashort
photoirradiation
only
3
s.
Furthermore,
within
PDCD
can
be
inhibited
bioconjugation
quencher-linked
peptide.
This
allows
construction
cancer-activatable
theranostic
probe
(CATP)
switches
on
signal
function
in
presence
cancer-overexpressed
enzyme.
Thereby,
CATP
represents
first
phototheranostic
permits
cancer-specific
therapy
under
preclinical
settings.
In
summary,
study
molecular
guideline
develop
probes
photoreactive
polymers.
Language: Английский
Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis
Liangwen Hao,
No information about this author
Jing Chen,
No information about this author
Quanshuang Li
No information about this author
et al.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Lateral
flow
assays
(LFAs)
are
widely
applicable
in
clinical
point‐of‐care
testing
(POCT)
due
to
their
unique
advantages
such
as
simplicity,
rapidity,
and
cost‐effectiveness.
However,
sensitivity
is
often
constrained
by
the
background
autofluorescence
of
biological
sample,
self‐matrix,
or
readout
technique,
thereby
leading
overlooking
trace
amounts
biomarkers
present
early
disease.
In
recent
years,
various
nanomaterials‐based
methods
have
been
developed
address
this
issue,
including
time‐gated
wavelength‐differentiated
strategy
external
modulated
for
separation
minimize
interference
from
samples.
This
review
provides
a
comprehensive
overview
low‐background
luminescent
nanoparticles
(LBLNPs)‐enhanced
LFA
systems,
focusing
on
analyzing
underlying
mechanism
these
nanomaterials
improving
accuracy
LFAs
platform
diagnosis.
Representative
examples
selected
demonstrate
potential
detecting
disease‐associated
samples
blood,
urine,
saliva
et
al.
Finally,
unresolved
challenges
future
development
prospects
briefly
discussed.
Language: Английский
Reactive oxygen species-mediated organic long-persistent luminophores light up biomedicine: from two-component separated nano-systems to integrated uni-luminophores
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
An
overview
of
the
recent
advances
in
reactive
oxygen
species-mediated
organic
long-persistent
luminophores,
including
their
history,
working
mechanisms,
design
strategies,
and
biomedical
applications.
Language: Английский
Ultrabright difuranfluoreno-dithiophen polymers for enhanced afterglow imaging of atherosclerotic plaques
Zhe Li,
No information about this author
Hui Cao,
No information about this author
Youjuan Wang
No information about this author
et al.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(13)
Published: March 26, 2025
Cardiovascular
diseases,
including
stroke
driven
by
atherosclerosis,
remain
a
leading
global
health
concern.
Current
diagnostic
imaging
modalities
such
as
magnetic
resonance
fail
to
characterize
oxidative
stress
within
atherosclerotic
plaques.
Here,
we
introduce
difuranfluoreno-dithiophen–based
polymers
designed
for
afterglow
imaging,
offering
ultrabright
luminescence,
ultralow-power
excitation
(0.087
milliwatts
per
square
centimeter),
and
ultrashort
acquisition
times
(0.01
seconds).
Through
molecular
engineering
strategy,
have
optimized
enhanced
reactive
oxygen
species
(ROS)
generation
capability,
ROS
capturing
fluorescence
quantum
yield,
resulting
in
an
increase
intensity
(~130-fold)
compared
commonly
used
2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene
polymer
(MEHPPV).
Additionally,
developed
ratiometric
nanoparticles
doped
with
stress–responsive
molecules,
enabling
of
markers
plaque.
This
approach
provides
tool
cardiovascular
diagnostics,
which
is
conducive
the
auxiliary
diagnosis
risk
stratification
atherosclerosis.
Language: Английский
A dark-state–dominated photochemical upconversion afterglow via triplet energy transfer relay
Hang Yuan,
No information about this author
Kuangshi Sun,
No information about this author
Xianlong Su
No information about this author
et al.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(17)
Published: April 25, 2025
Photochemical
afterglow
materials
have
drawn
considerable
attention
due
to
their
attractive
luminescent
properties
and
great
application
potential.
Considering
the
classical
photochemical
always
exhibit
poor
luminescence,
it
is
urgent
gain
fundamental
understanding
of
main
limiting
factors.
Here,
we
identified
existence
a
dark-state
triplet
in
process,
an
overwhelming
percentage
~98.5%
was
revealed
for
this
non-emissive
state.
Guided
by
these
observations,
proposed
activate
unprecedented
energy
transfer
relay
simultaneously
harness
singlet
energy.
Consequently,
upconverted
material
constructed
with
amazing
luminescence
performance
albeit
its
moderate
fluorescence
emission
property.
The
generality
strategy
evidenced
adaptation
similar
emitters
varied
wavelengths.
optimized
enabled
time-gated
upconversion
bioimaging
under
ultralow-power
excitation.
This
study
not
only
reveals
pathways
but
also
paves
way
rational
design
bright
ultralong
lifetime.
Language: Английский
Sensitive Fluorescent Determination of Matrix Metalloproteinase-2 (MMP-2) Using the Inner Filter Effect (IFE) with Carbon Dots and Aggregated Gold Nanoparticles
Analytical Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 15
Published: Dec. 5, 2024
Matrix
metalloproteinase-2
(MMP-2)
is
a
key
biomarker
involved
in
various
pathological
processes,
so
its
sensitive
and
selective
detection
of
great
clinical
significance.
A
fluorescent
sensor
for
the
MMP-2
was
successfully
designed
based
on
inner
filter
effect
(IFE)
between
carbon
dots
(CDs)
gold
nanoparticles
(AuNPs).
In
presence
MMP-2,
peptide
chains
are
hydrolyzed,
releasing
short
peptides
that
contain
thiol
groups
positive
charges,
thereby
inducing
aggregation
AuNPs.
This
disrupts
IFE
AuNPs
CDs,
leading
to
significant
enhancement
fluorescence.
By
monitoring
change
fluorescence
intensity
concentration
accurately
determined.
The
exhibited
linear
response
across
range
from
1.0
150
ng/mL,
with
limit
as
low
0.23
which
lower
than
those
previously
reported
methods.
Furthermore,
demonstrated
minimal
interference
coexisting
biochemical
substances
human
serum.
Notably,
applied
determine
serum,
showing
satisfactory
recovery
rates
ranging
98.8
1106.0%.
conclusion,
this
offers
high
selectivity
sensitivity
detection,
making
it
promising
tool
diagnosis
related
diseases.
Language: Английский