Self-assembly nanomedicine initiating cancer-immunity cycle with cascade reactions for boosted immunotherapy DOI
Yajing Guo,

Bingyuan Liu,

Lixin Yin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158143 - 158143

Published: Nov. 30, 2024

Language: Английский

Small-molecule fluorescent probes for detecting hydrogen peroxide in biological systems DOI

Yongqing Zhou,

Xiao‐Feng Yang, Hosoowi Lee

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216785 - 216785

Published: May 17, 2025

Language: Английский

Citations

0
Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy DOI Creative Commons
Edward R. H. Walter, Peter Kam‐Keung Leung, Lawrence Cho‐Cheung Lee

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The development of new and improved mitochondria-targeting photosensitisers (PSs) for photodynamic therapy (PDT) remains highly desirable, due to the critical role mitochondria play in maintaining healthy cellular function. Here, we report design, synthesis, photophysical properties biological characterisation a series di-iodinated BODIPY-based PSs, BODIPY-Mito-I-n, mitochondria-targeted PDT applications. Six BODIPY-Mito-I-n analogues were synthesised good yields, with fast reaction times between 30 60 min under mild conditions. di-iodination BODIPY scaffold enabled efficient population triplet state, leading high singlet oxygen (

Language: Английский

Citations

3
A New Near-infrared Fluorescence Probe for Highly Selective and Sensitive Detection and Imaging of Butyrylcholinesterase in Alzheimer's Disease Mice DOI
Jian Zhang, Xiaojie Tang, Honglan Qi

et al.

Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127377 - 127377

Published: Dec. 14, 2024

Language: Английский

Citations

2
An Activatable Heavy-Atom-Free Upconversion Photosensitizer for Targeted Imaging and Treatment of Tumors DOI
Chao Zhao,

Wanlu Sun,

Yanyan Zhu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Photodynamic therapy (PDT) is an innovative and promising method for treating tumors that has attracted significant interest but still faces several challenges, such as a lack of selectivity, deep penetration light, efficient ROS generation. To address these we optimized synthesized series photosensitizers successfully developed heavy-atom-free near-infrared FUCL photosensitizer NFh-NMe-2. This can generate singlet oxygen (1O2) induce cellular apoptosis under 808 nm light. For the safe ablation microtumors in vivo, activatable NFh-NTR was based on overexpression nitroreductase (NTR). could be activated by NTR, leading to release NFh-NMe-2, restoring fluorescence signal, effectively killing tumor cells light irradiation. work opens new possibilities chemical design cancer treatment.

Language: Английский

Citations

1
Self-assembly nanomedicine initiating cancer-immunity cycle with cascade reactions for boosted immunotherapy DOI
Yajing Guo,

Bingyuan Liu,

Lixin Yin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158143 - 158143

Published: Nov. 30, 2024

Language: Английский

Citations

0