One‐Pot and Gram‐Scale Synthesis of Fe‐Based Nanozymes with Tunable O2 Activation Pathway and Specificity Between Associated Enzymatic Reactions DOI
Yuwei Qiu, Tianqi Cheng, Bo Yuan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Nanozymes have recently gained attention for their low cost and high stability. However, unlike natural enzymes, they often exhibit multiple enzyme‐like activities, complicating use in selective bioassays. Since H 2 O are common substrates these reactions, controlling activation—and thus reaction specificity—is crucial. Recent advances tuning the chemical state of cerium enabled control over activation pathways tunable peroxidase/haloperoxidase‐like activities. In contrast, on an element oxidase/laccase nanozymes impact its activities remains unexplored. Herein, a facile one‐pot method is presented gram‐scale synthesis Fe‐based with compositions Fe 3 4 C by adjusting preparation temperatures. The ‐containing samples superior laccase‐like activity, while C‐containing counterparts demonstrate better oxidase‐like activity. This divergent behavior linked to surface species: abundant reactive 2+ promotes activity via 3+ ‐superoxo formation, whereas metallic facilitates OH radical generation Controlled improved sensitivity corresponding biomolecule detection, which should inform design enhanced specificity.

Language: Английский

High‐Density Accessible Iron Single‐Atom Catalyst for Durable and Temperature‐Adaptive Laminated Zinc‐Air Batteries DOI Open Access

Lan Ling,

Yonggan Wu,

Yukui Pei

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract Designing single‐atom catalysts (SACs) with high density of accessible sites by improving metal loading and utilization is a promising strategy to boost the catalytic activity, but remains challenging. Herein, site (SD) iron SAC (D‐Fe‐N/C) 11.8 wt.% Fe‐loading reported. The in situ scanning electrochemical microscopy technique attests that active SD D‐Fe‐N/C reach as 1.01 × 10 21 g −1 79.8%, respectively. Therefore, demonstrates superior oxygen reduction reaction (ORR) activity terms half‐wave potential 0.918 V turnover frequency 0.41 e s . excellent ORR property also demonstrated liquid zinc‐air batteries (ZABs), which exhibit peak power 306.1 mW cm −2 an ultra‐long cycling stability over 1200 h. Moreover, solid‐state laminated ZABs prepared presetting air flow layer show specific capacity 818.8 mA h , 520 h, wide temperature‐adaptive from −40 60 °C. This work not only offers possibilities metal‐loading for exploring efficient SACs, provides strategies device structure design toward advanced ZABs.

Language: Английский

Citations

2
Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single‐Atom Nanozyme Integrated 3D Nanoarray DOI Open Access

Peilin Wu,

Yi Li, Xun He

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Late-stage diagnosis is a major contributor to cancer mortality and thus leads increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers the identification of aggressive cancers. Here, develop single-atom nanozyme integrated nanoarray 3D nano-biointerface ultrasensitive electrochemical screening CTCs from hepatocellular carcinoma. This cytosensor capable identifying CTC at single-cell level, achieving an impressive area under curve 0.96 in receiver operating characteristics, comparable simulated multi-indicator diagnostic strategies. strategy shows great potential non-invasive carcinoma promising be applied universally diagnosis.

Language: Английский

Citations

1
Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications DOI Open Access

Mingwang Liu,

Weiqing Xu,

Yinjun Tang

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Nanozymes with atomically dispersed metal sites (ADzymes), especially single‐atom nanozymes, have attracted widespread attention in recent years due to their unique advantages mimicking the active of natural enzymes. These nanozymes not only maximize exposure catalytic but also possess superior activity performance, achieving challenging reactions. position ADzymes as highly promising candidates field sensing and biosensing. This review summarizes classification properties ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., achieve catalytical activity, specificity, multifunctionality. Then, we present advances different fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, electrochemiluminescence. Taking advantage resultant show great potential goal sensitivity, selectivity accuracy for detection various targets. Specifically, underlying mechanisms terms signal amplification were discussed detail. Finally, current challenges perspectives on development advanced are discussed.

Language: Английский

Citations

1
Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications DOI Open Access

Mingwang Liu,

Weiqing Xu,

Yinjun Tang

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Nanozymes with atomically dispersed metal sites (ADzymes), especially single‐atom nanozymes, have attracted widespread attention in recent years due to their unique advantages mimicking the active of natural enzymes. These nanozymes not only maximize exposure catalytic but also possess superior activity performance, achieving challenging reactions. position ADzymes as highly promising candidates field sensing and biosensing. This review summarizes classification properties ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., achieve catalytical activity, specificity, multifunctionality. Then, we present advances different fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, electrochemiluminescence. Taking advantage resultant show great potential goal sensitivity, selectivity accuracy for detection various targets. Specifically, underlying mechanisms terms signal amplification were discussed detail. Finally, current challenges perspectives on development advanced are discussed.

Language: Английский

Citations

0
Sensitive Lateral Flow Immunoassay Enabled by Signal Amplification Strategy with High Active Oxidase-Like Nanozymes DOI
Jie Zhu, Yunhui Cheng, Xufeng Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the peroxidase-like activity of 4Fe–Ni–B nanoparticles for analytical sensing DOI Creative Commons

Si-Hua Deng,

Ying‐Zhao Ma, Yi‐Fan Han

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7535 - 7545

Published: Jan. 1, 2025

Metal boride nanoenzymes are first reported to exhibit peroxidase-like activity. Their catalytic mechanisms were clarified via DFT. This work broadens their potential applications while advancing 2D metal development.

Language: Английский

Citations

0
Tandem Oxygen Activation for Efficient Aerobic Oxidation: The Underlying Function of Oxide in Metal/Oxide Catalysts DOI
Wenbin Jiang, Jingcong Hu,

Shuaikang Sang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1352 - 1360

Published: March 12, 2025

Language: Английский

Citations

0
Smartphone-Based Bimetallic Single-Atom Nanozyme Sensor Array Integrated with Deep Learning for Rapid Biothiol Detection DOI
Jiawei Wang,

Zhuohang Huang,

Xiaomeng Yu

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis DOI Open Access
Siyi Li,

E Jiaoting,

Xiucheng Zhao

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted their low catalytic efficiency, high toxicity, off‐target consumption. Herein, hetero‐trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed presence N P surface ligands from cross‐linked polyphosphazene interlayer‐coated MIL‐101(Fe). The 3D network TACs with uniform dispersion Cu, Co, Fe hetero‐single atoms effectively tailor active sites avoid metal sintering, thereby providing sufficient activity blooms. Nanovesicle membranes facilitate accumulation homologous targeting, recognition, endocytosis, addressing potentially toxicity defects. Therefore, outcome situ ROS‐bloom acts redox directly regulating oxidative stress tumor microenvironment. Meanwhile, intervene glutathione peroxidase 4, long‐chain acyl‐CoA synthetase cysteinyl aspartate specific proteinase‐3 pathways second messengers, fostering proclivity toward apoptosis lipid peroxidation‐regulated ferroptosis pathway concurrently, highlighting application prospects biomedical field.

Language: Английский

Citations

0
Construction of Frustrated Lewis Pairs for Efficient Artificial Enzyme DOI Open Access
Limin Ma, Ying Wang, Yaoyao Chen

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Optimizing the binding sites of substrates for small molecules activation plays a crucial role in enzyme‐like catalysts design. Herein, frustrated Lewis pairs (FLPs) are successfully constructed through boron (B) doping into CoO x (CoBO ) with abundant oxygen vacancies (O v ). The O optimizes valence active sites, creates coordinatively unsaturated state, and elongates distance pairs. electron‐deficient acid (LA) (Co) facilitate adsorption dissociation 2 , electron‐rich base (LB) (O) draw positively charged TMB closer to Co shorten reaction distance, which synergistically improve oxidase (OXD)‐like activity. Besides, increase electron density induced by FLPs promotes electrons transfer, intermediates stabilization, decreases energy barrier rate‐determining step . Significantly, proof‐of‐concept application colorimetric biosensing platform, as‐developed CoBO demonstrate highly sensitive selective detection capacity dopamine (DA) targets. This work verifies possibility activating catalysis.

Language: Английский

Citations

0